{"paper":{"title":"Characterization of the 3D microstructure of Ibuprofen tablets by means of synchrotron tomography","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cond-mat.mtrl-sci","authors_text":"Henning Mark\\\"otter, Ingo Manke, Jan-Henrik Finke, Markus Osenberg, Matthias Neumann, Ramon Cabiscol, Volker Schmidt","submitted_at":"2018-06-12T16:24:31Z","abstract_excerpt":"We present a methodology to characterize the 3D microstructure of Ibuprofen tablets, which strongly influences the strength and solubility kinetics of the final formulation, by means of synchrotron tomography. A physically coherent trinarization for greyscale images of Ibuprofen tablets consisting of the three phases microcrystalline cellulose, Ibuprofen and pores is presented. For this purpose, a hybrid approach is developed combining a trinarization by means of statistical learning with a trinarization based on a watershed algorithm. This hybrid approach allows us to compute microstructure c"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1806.04631","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}