{"paper":{"title":"Effect of finite size on cooperativity and rates of protein folding","license":"","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Chin-Kun Hu, D. Thirumalai, Edward P. O'Brien Jr., Mai Suan Li, Maksim Kouza","submitted_at":"2006-12-21T15:14:45Z","abstract_excerpt":"We analyze the dependence of cooperativity of the thermal denaturation transition and folding rates of globular proteins on the number of amino acid residues, $N$, using lattice models with side chains,off-lattice Go models and the available experimental data. A dimensionless measure of cooperativity, $\\Omega_c$ ($0 < \\Omega_c < \\infty$), scales as $\\Omega_c \\sim N^{\\zeta}$. The results of simulations and the analysis of experimental data further confirm the earlier prediction that $\\zeta$ is universal with $\\zeta = 1 +\\gamma$, where exponent $\\gamma$ characterizes the susceptibility of a self"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0612039","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}