{"paper":{"title":"Improving Longitudinal Targeted Maximum Likelihood Estimation in Target Trial Emulation using Joint Calibrated Weights","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Juliette M. Limozin, Li Su, Shaun R. Seaman","submitted_at":"2026-06-03T09:55:45Z","abstract_excerpt":"In target trial emulation (TTE), marginal structural models (MSMs) can be used to characterise per-protocol treatment effects over time. The MSM parameters are often estimated by inverse probability weighting (IPW), with weights estimated by maximum likelihood. However, IPW-based estimators can be unstable in small samples and are sensitive to misspecification of the weight models. An alternative method for estimating the MSM parameters is longitudinal targeted maximum likelihood estimation (LTMLE). LTMLE is double robust and potentially more efficient than IPW. Nevertheless, LTMLE also relies"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.04673","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.04673/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}