{"paper":{"title":"Molecular dynamics simulations reveal the role of ceramicine B as novel PPAR{\\gamma} partial agonist against type 2 diabetes","license":"http://creativecommons.org/publicdomain/zero/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Bidyut Mallick","submitted_at":"2018-08-25T08:25:21Z","abstract_excerpt":"Peroxisome proliferator-activated receptors gamma (PPAR{\\gamma}) are ligand-activated controllers of various metabolic actions and insulin sensitivity. PPAR{\\gamma} is thus considered as an important target to treat type 2 diabetes. Available PPAR{\\gamma} drugs (full agonists) have robust insulin-sensitizing properties but are accompanied by severe side effects leading to complicated health problems. Here, we have used molecular docking and a molecular dynamics simulation study to find a novel PPAR{\\gamma} ligand from a natural product. Our study suggests that the inhibition of ceramicine B in"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1808.08375","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}