{"paper":{"title":"A Digital Twin Framework for Adaptive Treatment Planning in Radiotherapy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Ashesh B. Jani, Chih-Wei Chang, Greeshma Agasthya, Jun Zhou, Keyur Shah, Mingzhe Hu, Pretesh Patel, Sri Sai Akkineni, Xiaofeng Yang, Yuan Gao","submitted_at":"2025-06-17T16:40:10Z","abstract_excerpt":"The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostatic lesion (DIL) boost represents a significant advancement in personalized radiotherapy. This framework integrates deep learning-based multi-atlas deformable image registration, daily patient anatomy updates via cone-beam CT (CBCT), and knowledge-based plan quality evaluation using the ProKnow scoring system to achieve clinical-equivalent plan quality with substantially reduced reoptimization times compared to traditi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.14701","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.14701/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}