{"paper":{"title":"A kinetic model of shear-induced rupture of short dsDNA","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cond-mat.soft","q-bio.QM"],"primary_cat":"q-bio.BM","authors_text":"Ayman Hussein, Ralf Bundschuh","submitted_at":"2026-06-09T14:58:44Z","abstract_excerpt":"Force-induced dissociation of short double-stranded DNA (dsDNA) is central to single-molecule biophysics and DNA nanotechnology, yet a physically grounded kinetic description of shear-induced rupture for finite-length constructs remains lacking. Here we develop a master equation framework built on a force-dependent nucleation-zipper pathway with single-base transitions, enabling direct calculation of dissociation rates and transition state distances over a broad force range. Applied to a DNA-gold nanoparticle-DNA construct under constant shear force, the model accurately reproduces the experim"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.10955","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.10955/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}