{"paper":{"title":"On the Promises and Limits of Multi-omics Integration for Deconvolution: The HADACA3 Benchmark","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Ana\\\"is Baudot, Aur\\'elia Baur\\`es, Carl Herrmann, CIML), David Causeur, Elise Amblard, Florent Chuffart, Hadaca Consortium, Hugo Barbot, LIG), Lionel Spinelli (TAGC, Lucie Lamothe, Magali Richard (APTIKAL, Mira Ayadi, Morgane T\\'er\\'ezol, Nicolas Homberg, Sebastien Dejean (IMT, UT3), Yasmina Kermezli, Yuna Blum","submitted_at":"2026-06-04T10:23:13Z","abstract_excerpt":"Understanding the cellular composition of complex tissues, such as tumors, is a key challenge in biology and medicine. A common approach, known as deconvolution, aims to estimate the cellular composition from bulk molecular measurements. With the growing availability of multiple types of molecular data, it is often assumed that combining data sources should improve deconvolution performance. Here, we present HADACA3, a community-driven benchmark designed to evaluate this assumption. We conducted a four-day collaborative competition followed by a large-scale computational benchmark, testing mor"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.05980","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.05980/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}