{"paper":{"title":"Aging induced structural alterations in SR-Mitochondria interaction in skeletal muscle: Emerging insights","license":"http://creativecommons.org/licenses/by-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.SC","authors_text":"Barsha Priyadarshini Kar, Naresh Chandra Bal, Sunil Pani, Unmod Senapati","submitted_at":"2026-06-16T03:18:50Z","abstract_excerpt":"Skeletal muscle undergo remarkable changes during aging including anatomical, ultrastructural, and moreover biochemical. The aging associated reduction of muscle mass, termed as sarcopenia, is a major factor in geriatric functional decline and frailty, contributing to the lowering of self-confidence. In an adult skeletal muscle fibers, sarcoplasmic reticulum (SR) and mitochondria exhibit most intricate and precise distribution along with the sarcolemmal (forming T-tubule), which is critical for muscle function. In healthy young muscle tissue, the close physical proximity of SR and mitochondria"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.17457","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.17457/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}