{"paper":{"title":"ChiSCAT: unsupervised learning of recurrent cellular micro-motion patterns from a chaotic speckle pattern","license":"http://creativecommons.org/licenses/by-sa/4.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"physics.optics","authors_text":"Andrii Trelin, Anja Clasen, Christian Rimmbach, Friedemann Reinhard, Paul Weinbrenner, Robert David, Sophie Kussauer","submitted_at":"2024-05-27T08:25:38Z","abstract_excerpt":"There is considerable evidence that action potentials are accompanied by \"intrinsic optical signals\", such as a nanometer-scale motion of the cell membrane. Here we present ChiSCAT, a technically simple imaging scheme that detects such signals with interferometric sensitivity. ChiSCAT combines illumination by a {\\bf ch}aotic speckle pattern and interferometric scattering microscopy ({\\bf iSCAT}) to sensitively detect motion in any point and any direction. The technique features reflective high-NA illumination, common-path suppression of vibrations and a large field of view. This approach maxim"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2405.16931","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2405.16931/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}