{"paper":{"title":"Lack of evidence for a substantial rate of templated mutagenesis in B cell diversification","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"q-bio.PE","authors_text":"Branden J Olson, Frederick A Matsen IV, Julia Fukuyama","submitted_at":"2020-07-02T18:50:09Z","abstract_excerpt":"B cell receptor sequences diversify through mutations introduced by purpose-built cellular machinery. A recent paper has concluded that a \"templated mutagenesis\" process is a major contributor to somatic hypermutation, and therefore immunoglobulin diversification, in mice and humans. In this proposed process, mutations in the immunoglobulin locus are introduced by copying short segments from other immunoglobulin genes. If true, this would overturn decades of research on B cell diversification, and would require a complete re-write of computational methods to analyze B cell data for these speci"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2007.01340","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2007.01340/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}