{"paper":{"title":"Sharpness characterizes Hill functions","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["math.CA","q-bio.QM"],"primary_cat":"math.OC","authors_text":"Marc Stephan","submitted_at":"2026-06-09T20:23:20Z","abstract_excerpt":"While long treated as empirical fits, Hill functions have been postulated to be the universal Hopfield barrier for sharpness of input-output responses by Martinez-Corral, Nam, DePace, and Gunawardena. A Hopfield barrier is a fundamental limit on how well biological systems can process information without expending energy. Their case rested on numerical findings for Hill coefficients $4$ and $6$. We give a precise formulation and proof of this: measuring sharpness by the supremum of the derivative in semi-log scale, any rational function $r(x)=(\\alpha_0+\\alpha_1 x+ \\cdots +\\alpha_n x^n)/(\\beta_"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.11426","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.11426/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}