{"paper":{"title":"Stabilization of microtubules due to microtubule-associated proteins: A simple model","license":"","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"q-bio.SC","authors_text":"Bindu S. Govindan, Jr. (Applied Biosciences Center, Virginia Tech), William B. Spillman","submitted_at":"2003-12-05T21:52:26Z","abstract_excerpt":"A theoretical model of stabilization of a microtubule assembly due to microtubule-associated-proteins(MAP) is presented. MAPs are assumed to bind to the microtubule filaments, thus preventing their disintegration following hydrolysis and enhancing further polymerization. Using mean-field rate equations and explicit numerical simulations, we show that the density of MAP (number of MAP per tubulin in the microtubule) has to exceed a critical value $\\rho_{c}$ to stabilize the structure against de-polymerization. At lower densities $\\rho < \\rho_{c}$, the microtubule population consists mostly of s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0312008","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}