{"paper":{"title":"Role of water in Protein Aggregation and Amyloid Polymorphism","license":"http://creativecommons.org/licenses/by/3.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"cond-mat.soft","authors_text":"D. Thirumalai, Govardhan Reddy, John E. Straub","submitted_at":"2011-07-25T00:52:14Z","abstract_excerpt":"A variety of neurodegenerative diseases are associated with the formation of amyloid plaques. Our incomplete understanding of this process underscores the need to decipher the principles governing protein aggregation. Most experimental and simulation studies have been interpreted largely from the perspective of proteins: the role of solvent has been relatively overlooked.\n  In this Account, we provide a perspective on how interactions with water affect folding landscapes of A$\\beta$ monomers, A$\\beta_{16-22}$ oligomer formation, and protofilament formation in a Sup35 peptide. Simulations show "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1107.4820","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}