{"paper":{"title":"Querying Counterfactuals on Tissue Graphs with Supervised Disentanglement","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG","stat.ML"],"primary_cat":"q-bio.GN","authors_text":"Abdul Moeed, Daniel Dimitrov, Marc Jan Bonder, Martin Rohbeck, Oliver Stegle, Pavlo Lutsik, Stefan Schrod","submitted_at":"2026-06-07T07:41:00Z","abstract_excerpt":"\\textit{Tissue graph counterfactuals} ask how a cell's expression would change under altered spatial neighbor contexts. Such queries are central to predicting cell behavior in tissues, but lack a unified definition, with existing methods targeting specific intervention types or treating cells as i.i.d. In this work, we first formalize \\textit{tissue graph counterfactuals} as a class of spatial interventions that either rewire connections between cells (\\textit{edge perturbation}) or modify the expression of their neighbors (\\textit{node perturbation}). We then introduce \\textit{Cellina} {\\rene"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.08493","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.08493/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}