{"as_of":"2026-08-21T11:55:00Z","caps":{"database_statements":6,"inbound":100,"outbound":100},"context_digest":"sha256:39a56208c06b840c4d2b99c0888a2bea1126342416b5ac614324b6beea1778b9","coverage":[{"denominator":57,"lane":"reference_resolution","note":"Typed states for the displayed outbound observations.","records_observed":57,"source":"paper_references, paper_reference_links","source_observed_at":"2026-08-15T14:17:51.854979Z","state":"measured"},{"denominator":57,"lane":"standing_notices","note":"One-hop event checks from named stored sources.","records_observed":57,"source":"scholarly_work_events, retraction_status_cache","source_observed_at":"2026-08-21T06:32:19.484+00:00","state":"measured"},{"denominator":0,"lane":"inbound_itemization","note":"Pith citing papers itemized under the disclosed page cap.","records_observed":0,"source":"paper_references, paper_reference_links","source_observed_at":null,"state":"measured"},{"denominator":1,"lane":"external_citation_measurements","note":"A source-named dated measurement, never combined with another source.","records_observed":0,"source":"cited_works","source_observed_at":null,"state":"measured"}],"external_citation_measurements":[],"inbound":[],"links":{"evidence":"/evidence","html":"/paper/2608.11483/citation-record","integrity":"/paper/2608.11483/integrity","json":"/paper/2608.11483/citation-record.json","paper":"/paper/2608.11483"},"outbound":[{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.26434/chemrxiv-2025-w1wsh","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.735660Z","title":"Bayesian","venue":null,"work_id":"de80f306-9684-42c1-91a1-0297a298b2cd","year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":1,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.572625Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:4298e33d59967f309787ff539cf707b209a36f277707c587dc56ee8e75021992","observation_id":"80c99ac4-8b71-4374-9d34-2a25a4b6a3ca","resolution":{"observed_at":"2026-08-15T14:17:52.741089Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.577830Z","title":null,"venue":null,"work_id":null,"year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":2,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.577830Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:bc0e3834a538d1217f86b1bad68f5dfd23593c2baeac793d9749a7c482417b74","observation_id":"20c11371-c723-4f82-b258-c7b69340fdf7","resolution":{"observed_at":"2026-08-15T14:17:51.577830Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":{"arxiv_id":"2310.20708","last_updated":"2025-01-07T13:11:19Z","snapshot_observed_at":"2026-08-20T11:22:18.020675Z","submitted_at":"2023-10-31T17:59:56Z","title":"Unexpected Improvements to Expected Improvement for Bayesian Optimization","version":3},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2310.20708","snapshot_observed_at":"2026-08-15T14:17:51.584236Z","title":"Unexpected","venue":null,"work_id":null,"year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":3,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.584236Z"},"links":{"cited_paper":"/paper/2310.20708","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:e92bbec4f351255fd879b3aa15485c5051e4f69c385defb4d86d24c7161c3944","observation_id":"28b7f1ea-dac3-4d4e-9c8d-eb6d8ffdc36c","resolution":{"observed_at":"2026-08-15T14:17:51.584236Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.48550/arxiv.2502.13959","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.704326Z","title":"and Watson, Ian A","venue":null,"work_id":"1cd46121-d544-4920-b6aa-98ce1a8fb63d","year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":4,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.589568Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:67ce34dfc6f9ee4e86e8702c21adaf97b71c327c93cdaafcd2c79bd35db36ab5","observation_id":"f3dc186f-b556-4b87-b405-d7bb7e171459","resolution":{"observed_at":"2026-08-15T14:17:52.709100Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.594596Z","title":"Nature Chemistry , volume =","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":5,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.594596Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:0965e8a09d194345c3499dd7c4f18ba4cccceae6f74c6d6f664ef67423c640f2","observation_id":"e715f3f7-e328-48dc-8958-347a756c9e7a","resolution":{"observed_at":"2026-08-15T14:17:51.594596Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.599503Z","title":"Nature , volume =","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":6,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.599503Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:2f5865a9b25cfe8fd7077fd5721b91ac03e10e3221ea2c72b3a6a85bb2728093","observation_id":"1226dad9-7481-4ce2-8d2f-362319cf1132","resolution":{"observed_at":"2026-08-15T14:17:51.599503Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.604421Z","title":"Assessing","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":7,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.604421Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:07727838ef3088e2b5e4629c6164d5d36d15ce9b0a001d5e7ebc6de28b2847c0","observation_id":"4696e12f-7708-431b-9563-8ab873f1224a","resolution":{"observed_at":"2026-08-15T14:17:51.604421Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.609304Z","title":"and Vaucher, Alain C","venue":null,"work_id":null,"year":2019},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":8,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.609304Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:55836b62ad49dda801257e39a17bd9668ec7232e95b8ca280f9940c953d2f377","observation_id":"29f07184-c7ea-405d-9dfa-b6be2d922f10","resolution":{"observed_at":"2026-08-15T14:17:51.609304Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1038/srep42717","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.597910Z","title":"doi:10.1038/srep42717 , urldate =","venue":null,"work_id":"b30fe875-29bd-4e5f-83fa-4702c5ef9a0d","year":2017},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":9,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.614386Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:21e4b3eef6787d5934949325903b0fb3b3726df17ebf1e620c567636cc5c017d","observation_id":"0cec8534-2ef2-469e-91a5-0b61ff041183","resolution":{"observed_at":"2026-08-15T14:17:52.603644Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2105.08195","last_updated":"2021-10-26T18:43:21Z","snapshot_observed_at":"2026-08-20T11:22:16.352458Z","submitted_at":"2021-05-17T23:31:42Z","title":"Parallel Bayesian Optimization of Multiple Noisy Objectives with Expected Hypervolume Improvement","version":2},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2105.08195","snapshot_observed_at":"2026-08-15T14:17:51.620068Z","title":"Parallel","venue":null,"work_id":null,"year":2021},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":10,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.620068Z"},"links":{"cited_paper":"/paper/2105.08195","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:61ebc73534f3ce92e2183bb251feaa5bd2f523e0c621cf41797ea8dcd2da1eaf","observation_id":"17043f05-5f26-4072-b164-956612c2b2a5","resolution":{"observed_at":"2026-08-15T14:17:51.620068Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1016/j.jclinepi.2021.08.001","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.567646Z","title":"Journal of Clinical Epidemiology , volume =","venue":null,"work_id":"24980524-1536-4555-9b41-2cbc3c29c38e","year":2021},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":11,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.625709Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:5a6ac1eddb2c5b49de5286c94bd8926b15d694a1edbef87dcf9c05bd3ade69f0","observation_id":"74f67081-a66c-4f4b-9035-f8a320647f0e","resolution":{"observed_at":"2026-08-15T14:17:52.572816Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1021/acs.jmedchem.1c00773","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.552523Z","title":"and Bochenkova, Elena and M","venue":null,"work_id":"7322680b-bf8b-4cfc-9da6-dbdb4ba1cee2","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":12,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.630399Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:e9d71ea630af39ab607f5cdff9c82c5bc4b98a8fcf391eb84ad7034eceeccee4","observation_id":"3c8e7629-9b3b-4ccc-a3d5-4f01537a98a2","resolution":{"observed_at":"2026-08-15T14:17:52.557087Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.916913Z","title":", year = 2018, month = jul, journal =","venue":null,"work_id":"1d5839e5-2864-4fc2-aae9-7e60a8d4d2b3","year":2018},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":13,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.635095Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:5a92620fc529c944cddbee5c4ae9d93781c410e4ff0dac10ffaa33220a3f7a5c","observation_id":"37ba255f-dbcd-489d-b131-0f1bc0d05116","resolution":{"observed_at":"2026-08-15T14:17:52.921561Z","resolver_source":"raw_fallback","status":"verified_fuzzy"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1093/nar/gkae236","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.538073Z","title":"doi:10.1093/nar/gkae236 , urldate =","venue":null,"work_id":"e3ca31f7-cfd1-4dba-adae-aeae7d4753c1","year":2024},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":14,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.639881Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:b6135d98a724968277fd28d10857cb78eb84f92f44a10fc38c0830db67065bc1","observation_id":"4d4409b7-9a29-49f7-bf48-792a3d770baf","resolution":{"observed_at":"2026-08-15T14:17:52.542813Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.644537Z","title":", year = 2025, month = oct, journal =","venue":null,"work_id":null,"year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":15,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.644537Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:3371931c6da099382f9f174cd8bbd955d3f10e9c900fc54a39a1de7bd5d578f0","observation_id":"56055749-063c-488c-a7a9-94689d15c697","resolution":{"observed_at":"2026-08-15T14:17:51.644537Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":{"arxiv_id":"2206.12411","last_updated":"2022-10-09T18:15:38Z","snapshot_observed_at":"2026-08-20T13:18:47.976843Z","submitted_at":"2022-06-22T20:36:49Z","title":"Sample Efficiency Matters: A Benchmark for Practical Molecular Optimization","version":2},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2206.12411","snapshot_observed_at":"2026-08-15T14:17:51.649367Z","title":", year = 2022, month = oct, number =","venue":null,"work_id":null,"year":2022},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":16,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.649367Z"},"links":{"cited_paper":"/paper/2206.12411","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:6cb407e501d97f0872a70fe3a1e85c50c1441638251d213f58068779a729207e","observation_id":"e2226cf4-9149-4dd1-b338-f7539188740f","resolution":{"observed_at":"2026-08-15T14:17:51.649367Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.654431Z","title":", year = 2020, month = dec, journal =","venue":null,"work_id":null,"year":2020},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":17,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.654431Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:60d462a82ba2b0f48e8b2417ea0abbf8abc8d47b07c049a9c722610154ad9f78","observation_id":"795c404a-d097-4321-8869-1ea87a0acfa7","resolution":{"observed_at":"2026-08-15T14:17:51.654431Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.659259Z","title":"Bidirectional","venue":null,"work_id":null,"year":2020},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":18,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.659259Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:160bdac58b2f297547e805d8e57e45d9c1c7222d6e57081ecf2960aeb72381d4","observation_id":"3efede2a-4841-4c31-8dea-e9596d9fb57f","resolution":{"observed_at":"2026-08-15T14:17:51.659259Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1039/c1md00017a","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.480214Z","title":"MedChemComm , volume =","venue":null,"work_id":"9630b529-9585-43e6-ba60-cf443d7091a5","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":19,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.663899Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:9037aacbff84b72c065f16d2ea0b904990f8a61934ced776c3c9b8fa79de7b55","observation_id":"02dc7c0e-5a7e-4c07-b107-59031d016871","resolution":{"observed_at":"2026-08-15T14:17:52.485758Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2408.13378","last_updated":"2026-07-03T13:51:19Z","snapshot_observed_at":"2026-08-18T18:49:04.833512Z","submitted_at":"2024-08-23T21:24:59Z","title":"DrugAgent: Reliable Multi-Agent Integration of Conflicting Biomedical Evidence for Drug-Target Interaction Assessment","version":5},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2408.13378","snapshot_observed_at":"2026-08-15T14:17:51.668539Z","title":"doi:10.48550/arXiv.2408.13378 , urldate =","venue":null,"work_id":null,"year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":20,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.668539Z"},"links":{"cited_paper":"/paper/2408.13378","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:778e21652383f8358868c248f7faf268ec2e32a506ec9133a0f9e4dcd23a17a7","observation_id":"c75e527c-5705-4735-98c1-652b592dd0a6","resolution":{"observed_at":"2026-08-15T14:17:51.668539Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.674144Z","title":"14 Examples of How","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":21,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.674144Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:c050219f82314b535ab667fe3acd8dff6f435a11dca2b1eeb5d9ff7b3d743aa6","observation_id":"8380d477-6247-4e22-a9a0-a2a481282dac","resolution":{"observed_at":"2026-08-15T14:17:51.674144Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1186/s13321-023-00703-1","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.441775Z","title":"doi:10.1186/s13321-023-00703-1 , urldate =","venue":null,"work_id":"1652a658-b417-4f40-9999-3838636e58e7","year":2023},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":22,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.680033Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:a31b87043414e1c9efdaee1420eaca9afb216bbb1e967a1fdad6e858220c1707","observation_id":"e6e87a89-189b-4a5b-8ef7-230f1f21f91c","resolution":{"observed_at":"2026-08-15T14:17:52.446612Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.685406Z","title":"Nucleic Acids Research , volume =","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":23,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.685406Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:4fb85e43420ace6d963088ac6918cfbe4fe8cc5a2df93999c5d6f4dd71719437","observation_id":"036b29f8-d923-4292-9260-7dadce5145e0","resolution":{"observed_at":"2026-08-15T14:17:51.685406Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.26434/chemrxiv.15003011/v1","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.417283Z","title":"and Zakharov, Alexey V","venue":null,"work_id":"3ccd5a28-c89c-49f5-903a-7aece5509c68","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":24,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.690706Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:4870de5182c460aad9f3a3c4721f31b379c6992f74f90f918ed10617cbb84b49","observation_id":"76ea065d-977e-480c-8320-5d13bdadf866","resolution":{"observed_at":"2026-08-15T14:17:52.422063Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.900924Z","title":"Proceedings of the","venue":null,"work_id":"c58b94d5-5eb2-458c-8c9b-d5d3009399fd","year":2020},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":25,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.695469Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:44a628023905726e08ca8f8e2f851b89bff508e0bd0a521518a6f533ebed782a","observation_id":"06a3d14f-2e82-491b-b557-53f048e0bf6a","resolution":{"observed_at":"2026-08-15T14:17:52.906901Z","resolver_source":"raw_fallback","status":"verified_fuzzy"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.884553Z","title":"A Sober Look at","venue":null,"work_id":"45e273b4-1ce7-4894-aca3-27a7dc166e63","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":26,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.699834Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:58f49247cf8c7ea8927ea29d29f870ace76420cd74852ffde9e26fa927f834b3","observation_id":"bfde850f-3da6-41f0-a91d-ec1910b70d0b","resolution":{"observed_at":"2026-08-15T14:17:52.890127Z","resolver_source":"raw_fallback","status":"verified_fuzzy"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2607.08010","last_updated":"2026-07-09T00:27:13Z","snapshot_observed_at":"2026-08-15T10:17:50.652713Z","submitted_at":"2026-07-09T00:27:13Z","title":"Tool-Making and Self-Evolving LLM Agents in Low-Latency Systems","version":1},"cited_work":{"arxiv_id":"2607.08010","doi":"10.48550/arxiv.2607.08010","metadata_source":"pith","pith_arxiv_id":"2607.08010","snapshot_observed_at":"2026-08-15T18:16:14.067578Z","title":"Tool-Making and Self-Evolving LLM Agents in Low-Latency Systems","venue":"cs.CL","work_id":"2cc35219-7ef9-4a50-871b-99951c1fbf05","year":2026},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":27,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.704904Z"},"links":{"cited_paper":"/paper/2607.08010","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:c9d241ea6cf810e1c5bd04410feb5e8263cf9a3cc990e173771c2220387a4761","observation_id":"a0943fdf-422e-4eec-995b-6998f4e12906","resolution":{"observed_at":"2026-08-15T14:17:52.407685Z","resolver_source":"local_arxiv","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.869031Z","title":null,"venue":null,"work_id":"93310440-9528-4600-8f08-b149da1e6949","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":28,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.710520Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:ffbe92836d672b4c4b34a570e7e135d8c28de6e584ec0ba54556f1fda780c759","observation_id":"d1eca27d-9b67-4a4a-bbe8-d5f72e07f777","resolution":{"observed_at":"2026-08-15T14:17:52.873873Z","resolver_source":"raw_fallback","status":"unresolved"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1186/s13321-017-0228-9","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.381219Z","title":"and Gabriel, Thomas and O'Donnell, T","venue":null,"work_id":"68ed4a89-cc3d-4bfe-988d-9aa84511123b","year":2017},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":29,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.715529Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:6fc884859acdd3e57e7074b6261a02057e36ada47edc9e112618ddfc78a3bce1","observation_id":"5a416905-a506-430e-a371-91952076ec08","resolution":{"observed_at":"2026-08-15T14:17:52.386889Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2605.28862","last_updated":"2026-05-21T19:12:19Z","snapshot_observed_at":"2026-07-06T23:38:23.512460Z","submitted_at":"2026-05-21T19:12:19Z","title":"Molecular Lead Optimization via Agentic Tool Planning","version":1},"cited_work":{"arxiv_id":"2605.28862","doi":"10.48550/arxiv.2605.28862","metadata_source":"pith","pith_arxiv_id":"2605.28862","snapshot_observed_at":"2026-08-15T18:16:14.067578Z","title":"Molecular Lead Optimization via Agentic Tool Planning","venue":"cs.LG","work_id":"f804d25b-aab6-444e-b586-64394360a1dc","year":2026},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":30,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.720115Z"},"links":{"cited_paper":"/paper/2605.28862","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:20d8a46a84b11fb697d2e1456e9c35ba139dbb8d3e0d822dd0de9b2a4bb70ae8","observation_id":"5ef5d6f3-944b-4447-a15b-de0b55238725","resolution":{"observed_at":"2026-08-15T14:17:52.370909Z","resolver_source":"local_arxiv","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2411.15692","last_updated":"2025-03-05T10:54:30Z","snapshot_observed_at":"2026-08-15T22:50:14.505857Z","submitted_at":"2024-11-24T03:06:59Z","title":"DrugAgent: Automating AI-aided Drug Discovery Programming through LLM Multi-Agent Collaboration","version":2},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2411.15692","snapshot_observed_at":"2026-08-15T14:17:51.725662Z","title":"doi:10.48550/arXiv.2411.15692 , urldate =","venue":null,"work_id":null,"year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":31,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.725662Z"},"links":{"cited_paper":"/paper/2411.15692","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:3e38deedd2f9848fd4ea082d607242879ba38bf385bc9c9f5da6fdf5ecec051f","observation_id":"018f3427-79f6-47a1-88de-66f07d857cf3","resolution":{"observed_at":"2026-08-15T14:17:51.725662Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.730855Z","title":"and He, Jiazhen and Tibo, Alessandro and Janet, Jon Paul and Voronov, Alexey and Mervin, Lewis H","venue":null,"work_id":null,"year":2024},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":32,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.730855Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:c16a1618b5bcd4fdcf279aa46ebb375c72f9596608d73040a2e230ba58d8e3d5","observation_id":"79f6fca9-2235-4406-aeac-bbf78d79dd51","resolution":{"observed_at":"2026-08-15T14:17:51.730855Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.48550/arxiv.2406.04628","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.319593Z","title":"and Ma, Jianzhu , year = 2024, month = jun, number =","venue":null,"work_id":"5f6e0527-ed12-4bcb-97b4-d895ba0de75f","year":2024},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":33,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.735131Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:c2afbfff32b57f6e075cc3ed4b37e62f2b5341f41b67f915fc67de1923e5fea4","observation_id":"67f897f3-0b92-4890-88d1-ab59ab8b163d","resolution":{"observed_at":"2026-08-15T14:17:52.324501Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.739654Z","title":"Nature Machine Intelligence , volume =","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":34,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.739654Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:2c26a06bf9acd37fde9baf7419adff4fae804da0e939adf8667e2a957a401907","observation_id":"52ab9d20-eff0-45c7-bf84-3849fb54157f","resolution":{"observed_at":"2026-08-15T14:17:51.739654Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":{"arxiv_id":"2511.02824","last_updated":"2025-11-05T18:26:43Z","snapshot_observed_at":"2026-08-17T03:14:20.962319Z","submitted_at":"2025-11-04T18:50:52Z","title":"Kosmos: An AI Scientist for Autonomous Discovery","version":2},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2511.02824","snapshot_observed_at":"2026-08-15T14:17:51.744282Z","title":"and Barabasi, Daniel L","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":35,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.744282Z"},"links":{"cited_paper":"/paper/2511.02824","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:c3918eb26d4b0e70476d752432d3e131c7ed410c2709e4768626e9a24f743872","observation_id":"c3234561-939c-4ab8-9759-c4c1fb0b2b70","resolution":{"observed_at":"2026-08-15T14:17:51.744282Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.748888Z","title":"and Banck, Michael and James, Craig A","venue":null,"work_id":null,"year":2011},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":36,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.748888Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:0ec47d2c81f311661a128419c333029a0a537dbe2bdd9944229a73b06b2655c9","observation_id":"f774978d-7866-41f4-8b34-475dce9ca30a","resolution":{"observed_at":"2026-08-15T14:17:51.748888Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1021/acs.jcim.3c01496","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.223119Z","title":null,"venue":null,"work_id":"c1dffbfb-ccfb-408b-997f-3d52ab059316","year":2024},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":37,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.753330Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:8d1850fa4060e68cacc1dba97fb3a1e8838488b1f0d8ecee242d1d73658f2f08","observation_id":"8ed172a3-3fd6-4016-b2a1-a791b48e141f","resolution":{"observed_at":"2026-08-15T14:17:52.228275Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.757724Z","title":"and Willett, Peter and Kadirkamanathan, Visakan and Luscombe, Christopher N","venue":null,"work_id":null,"year":2010},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":38,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.757724Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:de7596b06576bcfea176250af353448dd6ce69541a367242277ef482ca07ca3f","observation_id":"e884a834-c5ea-44ce-990e-9433632742d3","resolution":{"observed_at":"2026-08-15T14:17:51.757724Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.762929Z","title":"Boltz-2:","venue":null,"work_id":null,"year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":39,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.762929Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:bc2f6742e663169532d4360187ab00a836e1fba8e044d2ca332536ddb1edb016","observation_id":"5cdaef81-fa07-4c40-be06-d3f6c7e9a740","resolution":{"observed_at":"2026-08-15T14:17:51.762929Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.767567Z","title":"Science Advances , volume =","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":40,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.767567Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:58aec6a5900aec0a5ea89b6f9bba6ac22c974f62021501cd86823f7b3ed24f9f","observation_id":"bde7d427-bcf1-4adf-bc2a-7d9e89965a64","resolution":{"observed_at":"2026-08-15T14:17:51.767567Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":{"arxiv_id":"2602.16666","last_updated":"2026-06-02T02:15:05Z","snapshot_observed_at":"2026-08-19T21:25:20.240103Z","submitted_at":"2026-02-18T18:05:44Z","title":"Towards a Science of AI Agent Reliability","version":3},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2602.16666","snapshot_observed_at":"2026-08-15T14:17:51.771934Z","title":"Towards a","venue":null,"work_id":null,"year":2026},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":41,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.771934Z"},"links":{"cited_paper":"/paper/2602.16666","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:a3f7a6ba5b20514925adc448a8b9ae1056dc1e2d45a9afbb801cffe57485a3c4","observation_id":"98580478-0d69-4835-84d5-ab5b31e7ddf7","resolution":{"observed_at":"2026-08-15T14:17:51.771934Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.853961Z","title":null,"venue":null,"work_id":"38b140f9-5cbd-45de-afd8-7096ef839940","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":42,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.776782Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:f94da36734a13d55a9b33b9a0ad3372b797d6a8fd6b8014ba5a5cfed229d3542","observation_id":"7b78477d-61db-446a-842a-7d7ff9c8695e","resolution":{"observed_at":"2026-08-15T14:17:52.858670Z","resolver_source":"raw_fallback","status":"parse_uncertain"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.839169Z","title":"Nature Reviews Drug Discovery , doi =","venue":null,"work_id":"4dbff74e-bd2c-4b9f-94f4-4d03094ea517","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":43,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.781388Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:5b5cf319d4b9ff32c7a72035062024f499bf1425d841cda77a98148f04cc2346","observation_id":"de065ee4-2164-4e3a-a6ba-a4b2a99aa9eb","resolution":{"observed_at":"2026-08-15T14:17:52.844003Z","resolver_source":"raw_fallback","status":"verified_fuzzy"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.48550/arxiv.2510.27130","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.160766Z","title":"and Parikh, Ayaan and Vijayan, Rahul and Kasbekar, Shoman and Reid, Dylan and Bender, Andreas and Spjuth, Ola , year = 2025, month = oct, number =","venue":null,"work_id":"98e5faa0-21d1-4d8e-bbd1-7973783dad10","year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":44,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.785853Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:9e9e5da7058cb4390c115fde0aae70e92d29f86cbf0acfd775971c45abe36157","observation_id":"e2fce923-63dc-4760-9350-6876ddfd7d77","resolution":{"observed_at":"2026-08-15T14:17:52.166293Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.2174/138161212799436430","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.096186Z","title":", journal =","venue":null,"work_id":"dc19111a-f559-48e8-b75a-ddfce93dbb42","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":45,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.791542Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:d4791f2c5a84aee8a63df4af76733be8623859552d05f79381d91079ba349108","observation_id":"5a9a4a18-e993-4f57-8466-8fa655f709bd","resolution":{"observed_at":"2026-08-15T14:17:52.100868Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2402.10980","last_updated":"2024-12-09T03:01:35Z","snapshot_observed_at":"2026-08-20T11:22:23.022381Z","submitted_at":"2024-02-15T21:33:07Z","title":"ChemReasoner: Heuristic Search over a Large Language Model's Knowledge Space using Quantum-Chemical Feedback","version":5},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2402.10980","snapshot_observed_at":"2026-08-15T14:17:51.796054Z","title":"and Edwards, Carl and Agarwal, Khushbu and Olarte, Mariefel V","venue":null,"work_id":null,"year":2024},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":46,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.796054Z"},"links":{"cited_paper":"/paper/2402.10980","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:af84b3b24c9c384d909d28567a347ad2cf29a779b38f4e55af4cb41608686346","observation_id":"a9a8cf87-c350-4f95-b2b8-0e9cf7aff927","resolution":{"observed_at":"2026-08-15T14:17:51.796054Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.800969Z","title":"Acta Pharmaceutica Sinica B , volume =","venue":null,"work_id":null,"year":2022},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":47,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.800969Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:5988978854af90540b765b37c0f8d017a23519e2898b5c4487bec4b95c687e1d","observation_id":"eef11e88-4cf4-44c8-a8c2-c6148a840ee9","resolution":{"observed_at":"2026-08-15T14:17:51.800969Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.824165Z","title":null,"venue":null,"work_id":"78e63e77-f4b5-477b-b6af-cd0f7a087af6","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":48,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.805763Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:d386319806297a847622a8e1ce059007c96001288197c7baf9247f3e3e5e3a47","observation_id":"da030fc6-eb16-4b0d-aa98-815b1ba1b0f9","resolution":{"observed_at":"2026-08-15T14:17:52.829015Z","resolver_source":"raw_fallback","status":"unresolved"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1021/jm400378w","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.058036Z","title":"doi:10.1021/jm400378w , urldate =","venue":null,"work_id":"f9cb92ef-7b2b-48a8-b37d-29c1857a799c","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":49,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.810304Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:f8e50077f74864aff87bb6ac14b33896aed40402d24b0d6621ab62a6677b7b81","observation_id":"66712f79-2a67-48b8-bfaa-7c0271f5b683","resolution":{"observed_at":"2026-08-15T14:17:52.062621Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2406.16976","last_updated":"2025-03-07T17:24:35Z","snapshot_observed_at":"2026-08-20T11:22:22.608510Z","submitted_at":"2024-06-23T06:22:49Z","title":"Efficient Evolutionary Search Over Chemical Space with Large Language Models","version":3},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2406.16976","snapshot_observed_at":"2026-08-15T14:17:51.815172Z","title":"Efficient","venue":null,"work_id":null,"year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":50,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.815172Z"},"links":{"cited_paper":"/paper/2406.16976","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:1c39ac718e9bff2ed1a547ebd79eabe3814961203f1b905e43a88edff43eaab6","observation_id":"e7ff0628-968d-4912-b5e6-0ed2d0941403","resolution":{"observed_at":"2026-08-15T14:17:51.815172Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.48550/arxiv.2603.05532","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.027012Z","title":", year = 2026, month = mar, number =","venue":null,"work_id":"2c36a256-2a77-471d-9468-50738b7e9294","year":2026},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":51,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.821229Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:c474d94fd9f881d01050405e0e32b24f9cdb3768eaa7c5607f8d9bd5b816b6a9","observation_id":"154c0964-3a3e-4c4a-9a28-1a439651714f","resolution":{"observed_at":"2026-08-15T14:17:52.031597Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1039/d1sc05259d","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.957733Z","title":"Chemical Science , volume =","venue":null,"work_id":"1946c492-3ac5-46c2-b7f4-04ed28bbf940","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":52,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.827071Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:f4de62a545760fff64e74edc6fa88c707c956d9ce66f1fc7951d2328e924499a","observation_id":"99e7913b-88fb-4cbf-bb58-81e44dc75650","resolution":{"observed_at":"2026-08-15T14:17:51.963190Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1021/acs.jcim.4c00412","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.941983Z","title":"and Willson, Timothy M","venue":null,"work_id":"a5e306d0-e718-463c-b17d-6e5fd7cd1143","year":2024},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":53,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.832596Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:c49e203d153718a2787451c484d0d85e4c52dbbc4313a9922d174c0e0205f6a6","observation_id":"820103aa-91d0-4443-842b-d7dfc789c13b","resolution":{"observed_at":"2026-08-15T14:17:51.946651Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":"raw_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:52.809138Z","title":"Model Context Protocol , urldate =","venue":null,"work_id":"827702c5-bc9b-4cda-8e17-d15067deec0e","year":null},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":54,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.838114Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:8cc25d5b449531945d6dd450bc7702b785c47a7c35a672cd8ce7aad8384344b3","observation_id":"cd96adef-8766-471a-824d-f1ffe6d029fc","resolution":{"observed_at":"2026-08-15T14:17:52.814331Z","resolver_source":"raw_fallback","status":"verified_fuzzy"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2501.13824","last_updated":"2025-08-22T12:12:09Z","snapshot_observed_at":"2026-08-16T04:37:39.933655Z","submitted_at":"2025-01-23T16:45:51Z","title":"Can Hallucinations Help? Boosting LLMs for Drug Discovery","version":2},"cited_work":{"arxiv_id":"2501.13824","doi":"10.48550/arxiv.2501.13824","metadata_source":"pith","pith_arxiv_id":"2501.13824","snapshot_observed_at":"2026-08-15T18:16:14.067578Z","title":"Can Hallucinations Help? Boosting LLMs for Drug Discovery","venue":"cs.CL","work_id":"ab1b8faa-ce76-4d4d-a78c-d5c504a2a2bf","year":2025},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":55,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.842579Z"},"links":{"cited_paper":"/paper/2501.13824","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:da39602b6b2cc673486e1dd35858d66eb7c5cfa711f6244be622dcc65d26a201","observation_id":"66e9c6c5-47d5-44b2-add7-adf4982665ad","resolution":{"observed_at":"2026-08-15T14:17:51.931559Z","resolver_source":"local_arxiv","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":null,"cited_work":{"arxiv_id":null,"doi":"10.1021/acs.jcim.6c00148","metadata_source":"doi_reference","pith_arxiv_id":null,"snapshot_observed_at":"2026-08-15T14:17:51.902508Z","title":"doi:10.1021/acs.jcim.6c00148 , urldate =","venue":null,"work_id":"598c92e4-f1f8-43eb-815c-43cb8c3bef2c","year":2026},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":56,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.850021Z"},"links":{"citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:8dab80881acf07d44bf11af0566401e16a28945503b74e3c8c2627cd44db34d1","observation_id":"db543d68-65a9-4cdb-b03c-8faaac7ddc23","resolution":{"observed_at":"2026-08-15T14:17:51.908536Z","resolver_source":"doi","status":"verified_exact"},"standing_notice":{"events":[],"observation":"No event found in the named queried sources as of 2026-08-21T06:32:19.484+00:00.","reason":null,"source_receipts":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"state":"measured"}},{"citation":{"cited_paper":{"arxiv_id":"2605.12784","last_updated":"2026-05-14T05:07:36Z","snapshot_observed_at":"2026-08-15T20:36:08.627355Z","submitted_at":"2026-05-12T21:58:14Z","title":"ToolMol: Evolutionary Agentic Framework for Multi-objective Drug Discovery","version":2},"cited_work":{"arxiv_id":null,"doi":null,"metadata_source":null,"pith_arxiv_id":"2605.12784","snapshot_observed_at":"2026-08-15T14:17:51.854979Z","title":"and Vadgama, Sharvaree and Varambally, Sumanth and Eckmann, Peter and Gilson, Michael K","venue":null,"work_id":null,"year":2026},"citing_paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization","version":1},"reference_index":57,"source":"arxiv_source","source_observed_at":"2026-08-15T14:17:51.854979Z"},"links":{"cited_paper":"/paper/2605.12784","citing_paper":"/paper/2608.11483"},"observation_digest":"sha256:6482b791959228d7e4642fbb53dc64f93b6216e10c748da110d4d96973e04f92","observation_id":"2a0dec03-e9bc-40a4-8ee1-2d91e23c0618","resolution":{"observed_at":"2026-08-15T14:17:51.854979Z","resolver_source":null,"status":"unresolved"},"standing_notice":{"events":[],"reason":"canonical_work_link_unavailable","source_receipts":[],"state":"unavailable"}}],"paper":{"arxiv_id":"2608.11483","last_updated":"2026-08-11T22:50:56Z","latest_version":1,"primary_category":"cs.AI","snapshot_observed_at":"2026-08-20T11:20:42.373219Z","submitted_at":"2026-08-11T22:50:56Z","title":"A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization"},"reference_resolution":{"displayed":57,"state_counts":{"malformed_identifier":0,"metadata_mismatch":0,"parse_uncertain":1,"unresolved":29,"verified_exact":22,"verified_fuzzy":5},"total_outbound_references":57},"refusal":"A citation records a reference. It does not transfer a finding from one paper to another.","schema":"pith.paper-citation-record.v1","standing_sources":[{"observed_at":"2026-08-21T06:32:19.484+00:00","source":"crossref"},{"observed_at":"2026-08-21T06:32:16.066871+00:00","source":"retraction_watch"}],"thesis":"As of 21 August 2026, this Paper Citation Record lists 57 of 57 outbound references and 0 inbound Pith citation observations for arXiv:2608.11483."}