{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2012:2L4UUXKJQZKFMME24EJSYQPQTT","short_pith_number":"pith:2L4UUXKJ","schema_version":"1.0","canonical_sha256":"d2f94a5d49865456309ae1132c41f09cf458f9c45385ddf4a3b29400225c6e48","source":{"kind":"arxiv","id":"1201.1094","version":1},"attestation_state":"computed","paper":{"title":"Mathematics of the NFAT signalling pathway","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.DS"],"primary_cat":"q-bio.MN","authors_text":"Alan D. Rendall","submitted_at":"2012-01-05T09:41:52Z","abstract_excerpt":"This paper is a mathematical study of some aspects of the signalling pathway leading to the activation of the transcription factor NFAT (nuclear factor of activated T cells). Activation takes place by dephosphorylation at multiple sites. This has been modelled by Salazar and H\\\"ofer using a large system of ordinary differential equations depending on many parameters. With the help of chemical reaction network theory we show that for any choice of the parameters this system has a unique stationary solution for each value of the conserved quantity given by the total amount of NFAT and that all s"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1201.1094","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-01-05T09:41:52Z","cross_cats_sorted":["math.DS"],"title_canon_sha256":"0f4236c91643f5f7c58e674ea44f36a48e554c9d7ed19775b858b252837593fc","abstract_canon_sha256":"e4cc1d307dfadd0a556fd68ec68dd9bf2176a7c2c7c91b64e01d5b983cb90cc0"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:05:06.191845Z","signature_b64":"quGK/PWTQrEJsW8awSRelXmU/1YhV5uODshy9qPbomDmdZU8MviPzJCTPxUL9n0x7HsTBBsY7GntNE8OTdXsCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d2f94a5d49865456309ae1132c41f09cf458f9c45385ddf4a3b29400225c6e48","last_reissued_at":"2026-05-18T04:05:06.191217Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:05:06.191217Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Mathematics of the NFAT signalling pathway","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.DS"],"primary_cat":"q-bio.MN","authors_text":"Alan D. Rendall","submitted_at":"2012-01-05T09:41:52Z","abstract_excerpt":"This paper is a mathematical study of some aspects of the signalling pathway leading to the activation of the transcription factor NFAT (nuclear factor of activated T cells). Activation takes place by dephosphorylation at multiple sites. This has been modelled by Salazar and H\\\"ofer using a large system of ordinary differential equations depending on many parameters. With the help of chemical reaction network theory we show that for any choice of the parameters this system has a unique stationary solution for each value of the conserved quantity given by the total amount of NFAT and that all s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1201.1094","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1201.1094","created_at":"2026-05-18T04:05:06.191291+00:00"},{"alias_kind":"arxiv_version","alias_value":"1201.1094v1","created_at":"2026-05-18T04:05:06.191291+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1201.1094","created_at":"2026-05-18T04:05:06.191291+00:00"},{"alias_kind":"pith_short_12","alias_value":"2L4UUXKJQZKF","created_at":"2026-05-18T12:26:50.516681+00:00"},{"alias_kind":"pith_short_16","alias_value":"2L4UUXKJQZKFMME2","created_at":"2026-05-18T12:26:50.516681+00:00"},{"alias_kind":"pith_short_8","alias_value":"2L4UUXKJ","created_at":"2026-05-18T12:26:50.516681+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT","json":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT.json","graph_json":"https://pith.science/api/pith-number/2L4UUXKJQZKFMME24EJSYQPQTT/graph.json","events_json":"https://pith.science/api/pith-number/2L4UUXKJQZKFMME24EJSYQPQTT/events.json","paper":"https://pith.science/paper/2L4UUXKJ"},"agent_actions":{"view_html":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT","download_json":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT.json","view_paper":"https://pith.science/paper/2L4UUXKJ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1201.1094&json=true","fetch_graph":"https://pith.science/api/pith-number/2L4UUXKJQZKFMME24EJSYQPQTT/graph.json","fetch_events":"https://pith.science/api/pith-number/2L4UUXKJQZKFMME24EJSYQPQTT/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT/action/timestamp_anchor","attest_storage":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT/action/storage_attestation","attest_author":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT/action/author_attestation","sign_citation":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT/action/citation_signature","submit_replication":"https://pith.science/pith/2L4UUXKJQZKFMME24EJSYQPQTT/action/replication_record"}},"created_at":"2026-05-18T04:05:06.191291+00:00","updated_at":"2026-05-18T04:05:06.191291+00:00"}