{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:2LOBIK7SAZYEYYYBDH4ADTLV3N","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9e3e7070412767e879b809c5fdb9d02c4c54374e1d37e8011efef5211c8b5bc5","cross_cats_sorted":["q-bio.GN"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"cs.CE","submitted_at":"2015-05-30T07:02:48Z","title_canon_sha256":"80e7d979cab48fee30c862af6672f4e4416d121ccc78b963dc863910482fc50e"},"schema_version":"1.0","source":{"id":"1506.00080","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1506.00080","created_at":"2026-05-18T01:37:22Z"},{"alias_kind":"arxiv_version","alias_value":"1506.00080v2","created_at":"2026-05-18T01:37:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1506.00080","created_at":"2026-05-18T01:37:22Z"},{"alias_kind":"pith_short_12","alias_value":"2LOBIK7SAZYE","created_at":"2026-05-18T12:29:02Z"},{"alias_kind":"pith_short_16","alias_value":"2LOBIK7SAZYEYYYB","created_at":"2026-05-18T12:29:02Z"},{"alias_kind":"pith_short_8","alias_value":"2LOBIK7S","created_at":"2026-05-18T12:29:02Z"}],"graph_snapshots":[{"event_id":"sha256:3690c5ce04ace2a6b7c5b0db5606ac6f430301479e40ef7ced1dca6cabcc0375","target":"graph","created_at":"2026-05-18T01:37:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Motivation: The consistent amount of different types of omics data requires novel methods of analysis and data integration. In this work we describe Regression2Net, a computational approach to analyse gene expression and methylation profiles via regression analysis and network-based techniques.\n  Results: We identified 284 and 447 unique candidate genes potentially associated to the Glioblastoma pathology from two networks inferred from mixed genetic datasets. In-depth biological analysis of these networks reveals genes that are related to energy metabolism, cell cycle control (AATF), immune s","authors_text":"Francesco Gadaleta, Kyrylo Bessonov","cross_cats":["q-bio.GN"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"cs.CE","submitted_at":"2015-05-30T07:02:48Z","title":"Integration of Gene Expression Data and Methylation Reveals Genetic Networks for Glioblastoma"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1506.00080","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:31d4a9ec6ef335634a052bcf22ecc826e6a7bb6a999245ac79b4cb4337607fd8","target":"record","created_at":"2026-05-18T01:37:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9e3e7070412767e879b809c5fdb9d02c4c54374e1d37e8011efef5211c8b5bc5","cross_cats_sorted":["q-bio.GN"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"cs.CE","submitted_at":"2015-05-30T07:02:48Z","title_canon_sha256":"80e7d979cab48fee30c862af6672f4e4416d121ccc78b963dc863910482fc50e"},"schema_version":"1.0","source":{"id":"1506.00080","kind":"arxiv","version":2}},"canonical_sha256":"d2dc142bf206704c630119f801cd75db5b0aa7db63fe1ac5ef35168dc2fa9a73","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d2dc142bf206704c630119f801cd75db5b0aa7db63fe1ac5ef35168dc2fa9a73","first_computed_at":"2026-05-18T01:37:22.949400Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:37:22.949400Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"G552dkNdTcjnhaUad+MwVZ1HuJLkVfXON+KazPU39uDWqqzBQFNf+t9TjBh3RUBqir4tPLKWwS9lUATLuPubCQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:37:22.950205Z","signed_message":"canonical_sha256_bytes"},"source_id":"1506.00080","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:31d4a9ec6ef335634a052bcf22ecc826e6a7bb6a999245ac79b4cb4337607fd8","sha256:3690c5ce04ace2a6b7c5b0db5606ac6f430301479e40ef7ced1dca6cabcc0375"],"state_sha256":"c5785732197478c562d574b8ac993507e26b30ef0701659b10b432cd65800a1e"}