{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:335JPYNUYHTDRHJVJRGFLE4XOR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e1ece3973c1d1937568970960a529f73afbe2efed3b54fdd8e578f70a577ffa9","cross_cats_sorted":["q-bio.BM","q-bio.CB"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-06T20:33:47Z","title_canon_sha256":"7c917ac1ab306b324b1439b480bf3eca431c237d6841b6cf8a019e360cc289db"},"schema_version":"1.0","source":{"id":"1204.1558","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1204.1558","created_at":"2026-05-18T03:58:23Z"},{"alias_kind":"arxiv_version","alias_value":"1204.1558v1","created_at":"2026-05-18T03:58:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1204.1558","created_at":"2026-05-18T03:58:23Z"},{"alias_kind":"pith_short_12","alias_value":"335JPYNUYHTD","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_16","alias_value":"335JPYNUYHTDRHJV","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_8","alias_value":"335JPYNU","created_at":"2026-05-18T12:26:50Z"}],"graph_snapshots":[{"event_id":"sha256:666794cb7690df714da191f621219b0b81337977b06c62870cc3781f18ad9cc8","target":"graph","created_at":"2026-05-18T03:58:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \\alpha7 subunit (\\alpha7*). Most of these reports involve either indirect measurements of KYNA effects on \\alpha7 nAChR function, or are reports of KYNA effects in complicated in vivo systems. However, a recent report investigating KYNA interactions with \\alpha7 nAChRs failed to detect an interaction using direct measureme","authors_text":"Andrew L. Varnell, Donald C. Cooper, Kevin J. Staley, Peter Dobelis","cross_cats":["q-bio.BM","q-bio.CB"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-06T20:33:47Z","title":"Nicotinic {\\alpha}7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1204.1558","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:caaa233c3dbbdbc13c4294eafb0de802acb8649f66bd53ee44341932660b94da","target":"record","created_at":"2026-05-18T03:58:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e1ece3973c1d1937568970960a529f73afbe2efed3b54fdd8e578f70a577ffa9","cross_cats_sorted":["q-bio.BM","q-bio.CB"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-06T20:33:47Z","title_canon_sha256":"7c917ac1ab306b324b1439b480bf3eca431c237d6841b6cf8a019e360cc289db"},"schema_version":"1.0","source":{"id":"1204.1558","kind":"arxiv","version":1}},"canonical_sha256":"defa97e1b4c1e6389d354c4c5593977474b03aeb661784720c4f988356ba426f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"defa97e1b4c1e6389d354c4c5593977474b03aeb661784720c4f988356ba426f","first_computed_at":"2026-05-18T03:58:23.986264Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:58:23.986264Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ar/plpxKHtUQxDQrq1XJTm5IXSEjrdCqlt840LhGbIlf+aJsx2TOOx0by98iCyS0q44cGAjI29OgbK+fsmn6Bg==","signature_status":"signed_v1","signed_at":"2026-05-18T03:58:23.986902Z","signed_message":"canonical_sha256_bytes"},"source_id":"1204.1558","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:caaa233c3dbbdbc13c4294eafb0de802acb8649f66bd53ee44341932660b94da","sha256:666794cb7690df714da191f621219b0b81337977b06c62870cc3781f18ad9cc8"],"state_sha256":"a2b111302046ef3453f8065eb584a0f2ae7aadcf5e10e14684aca201337d2e25"}