{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:3D6HCC2IW3KMZTS227CP5J4MMV","short_pith_number":"pith:3D6HCC2I","canonical_record":{"source":{"id":"2308.06578","kind":"arxiv","version":5},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2023-08-12T14:26:38Z","cross_cats_sorted":[],"title_canon_sha256":"71f7164be1f3db8a4542a5c90e430eb71b78b2054c4d89c4dcb921c55a79366f","abstract_canon_sha256":"5558a7787baf189a7e0b955fff89d447794453ddf8f183f65c597d27718e6f0d"},"schema_version":"1.0"},"canonical_sha256":"d8fc710b48b6d4ccce5ad7c4fea78c654a0f203be0e275c6f4a84685c1526d27","source":{"kind":"arxiv","id":"2308.06578","version":5},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2308.06578","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"arxiv_version","alias_value":"2308.06578v5","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2308.06578","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"pith_short_12","alias_value":"3D6HCC2IW3KM","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"pith_short_16","alias_value":"3D6HCC2IW3KMZTS2","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"pith_short_8","alias_value":"3D6HCC2I","created_at":"2026-07-05T09:08:45Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:3D6HCC2IW3KMZTS227CP5J4MMV","target":"record","payload":{"canonical_record":{"source":{"id":"2308.06578","kind":"arxiv","version":5},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2023-08-12T14:26:38Z","cross_cats_sorted":[],"title_canon_sha256":"71f7164be1f3db8a4542a5c90e430eb71b78b2054c4d89c4dcb921c55a79366f","abstract_canon_sha256":"5558a7787baf189a7e0b955fff89d447794453ddf8f183f65c597d27718e6f0d"},"schema_version":"1.0"},"canonical_sha256":"d8fc710b48b6d4ccce5ad7c4fea78c654a0f203be0e275c6f4a84685c1526d27","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:08:45.478177Z","signature_b64":"tbjUfew76BGnt0/FmzzB6MGga7djB8w3FTeJKoffY493L+Q82dH9wOLZ9Sk3lCBuoeMijsItTTO9sfaJ8wGnBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d8fc710b48b6d4ccce5ad7c4fea78c654a0f203be0e275c6f4a84685c1526d27","last_reissued_at":"2026-07-05T09:08:45.477621Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:08:45.477621Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2308.06578","source_version":5,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:08:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"M1OSfjD78oPC4o0IHJWzuG25+zoIkPt5CZnaR8u9g66s/JIxQg/JEFDpk7qGwRYcCQzEfi79nMKMTYAj7gYKDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T10:45:44.894179Z"},"content_sha256":"5260ad4f7738f6544dcaeb1d9216cb321842051c2bc86427b1890d02f6933585","schema_version":"1.0","event_id":"sha256:5260ad4f7738f6544dcaeb1d9216cb321842051c2bc86427b1890d02f6933585"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:3D6HCC2IW3KMZTS227CP5J4MMV","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The time is ripe to reverse engineer an entire nervous system: simulating behavior from neural interactions","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Adam Marblestone (Convergent Research), Anne C Hart (Brown University), Ben Baker (Colby College), Brett Mensh (Optimize Science), Brock Wester (Johns Hopkins APL), Christopher Fang-Yen (Ohio State University), Daniel Colon-Ramos (Yale University), Donglai Wei (Boston College), Eduardo J Izquierdo (Rose-Hulman Institute of Technology), Edward S Boyden (MIT), Eli Shlizerman (University of Washington), Eva Dyer (Georgia Institute of Technology), Eviatar Yemini (UMass), Gal Haspel (NJIT), George Church (Harvard University), Guangyu Robert Yang (MIT), Hanspeter Pfister (Harvard University), Horacio G Rotstein (NJIT), Isabel Beets (KU Leuven), Jeffrey Brown (MIT), Jordan Matelsky (University of Pennsylvania), Joshua W. Shaevitz (Princeton University), Kanaka Rajan (Harvard Medical School), Konrad P Kording (University of Pennsylvania), Konstantinos Kagias (MIT), Manuel Zimmer (University of Vienna), Michael A Skuhersky (MIT), Miriam B Goodman (Stanford University), Monika Scholz (Max Planck Institute for Neurobiology of Behavior), Netta Cohen (University of Leeds), Quilee Simeon (MIT), Shawn Lockery (University of Oregon), Steven Flavell (MIT), Talmo D Pereira (Salk Institute), Vineet Tiruvadi (Hume AI), Vivek Venkatachalam (Northeastern University), Yangning Lu (MIT)","submitted_at":"2023-08-12T14:26:38Z","abstract_excerpt":"Just like electrical engineers understand how microprocessors execute programs in terms of how transistor currents are affected by their inputs, neuroscientists want to understand behavior production in terms of how neuronal outputs are affected by their inputs and internal states. This dependency of neuronal outputs on inputs can be described by a state-dependent input-output (IO)-function. However, to reliably identify these IO-functions, we need to perturb each input and combinations of inputs while observing all the outputs. Here, we argue that such completeness is possible in C. elegans; "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2308.06578","kind":"arxiv","version":5},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2308.06578/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:08:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/tpradvV+koVWABGsUiUzVT4DXJpuewQnIS5YFen7CaDAYyRTTYXa9Fy94aqvY7GKHS15IdmB20olsx4iCrmCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T10:45:44.894580Z"},"content_sha256":"a6e5a7a2404c9db1ac027e65c3ac1c9f277fb32c04ebb0e3d8817d4a15dc16a3","schema_version":"1.0","event_id":"sha256:a6e5a7a2404c9db1ac027e65c3ac1c9f277fb32c04ebb0e3d8817d4a15dc16a3"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/3D6HCC2IW3KMZTS227CP5J4MMV/bundle.json","state_url":"https://pith.science/pith/3D6HCC2IW3KMZTS227CP5J4MMV/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/3D6HCC2IW3KMZTS227CP5J4MMV/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-13T10:45:44Z","links":{"resolver":"https://pith.science/pith/3D6HCC2IW3KMZTS227CP5J4MMV","bundle":"https://pith.science/pith/3D6HCC2IW3KMZTS227CP5J4MMV/bundle.json","state":"https://pith.science/pith/3D6HCC2IW3KMZTS227CP5J4MMV/state.json","well_known_bundle":"https://pith.science/.well-known/pith/3D6HCC2IW3KMZTS227CP5J4MMV/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:3D6HCC2IW3KMZTS227CP5J4MMV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5558a7787baf189a7e0b955fff89d447794453ddf8f183f65c597d27718e6f0d","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2023-08-12T14:26:38Z","title_canon_sha256":"71f7164be1f3db8a4542a5c90e430eb71b78b2054c4d89c4dcb921c55a79366f"},"schema_version":"1.0","source":{"id":"2308.06578","kind":"arxiv","version":5}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2308.06578","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"arxiv_version","alias_value":"2308.06578v5","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2308.06578","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"pith_short_12","alias_value":"3D6HCC2IW3KM","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"pith_short_16","alias_value":"3D6HCC2IW3KMZTS2","created_at":"2026-07-05T09:08:45Z"},{"alias_kind":"pith_short_8","alias_value":"3D6HCC2I","created_at":"2026-07-05T09:08:45Z"}],"graph_snapshots":[{"event_id":"sha256:a6e5a7a2404c9db1ac027e65c3ac1c9f277fb32c04ebb0e3d8817d4a15dc16a3","target":"graph","created_at":"2026-07-05T09:08:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2308.06578/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Just like electrical engineers understand how microprocessors execute programs in terms of how transistor currents are affected by their inputs, neuroscientists want to understand behavior production in terms of how neuronal outputs are affected by their inputs and internal states. This dependency of neuronal outputs on inputs can be described by a state-dependent input-output (IO)-function. However, to reliably identify these IO-functions, we need to perturb each input and combinations of inputs while observing all the outputs. Here, we argue that such completeness is possible in C. elegans; ","authors_text":"Adam Marblestone (Convergent Research), Anne C Hart (Brown University), Ben Baker (Colby College), Brett Mensh (Optimize Science), Brock Wester (Johns Hopkins APL), Christopher Fang-Yen (Ohio State University), Daniel Colon-Ramos (Yale University), Donglai Wei (Boston College), Eduardo J Izquierdo (Rose-Hulman Institute of Technology), Edward S Boyden (MIT), Eli Shlizerman (University of Washington), Eva Dyer (Georgia Institute of Technology), Eviatar Yemini (UMass), Gal Haspel (NJIT), George Church (Harvard University), Guangyu Robert Yang (MIT), Hanspeter Pfister (Harvard University), Horacio G Rotstein (NJIT), Isabel Beets (KU Leuven), Jeffrey Brown (MIT), Jordan Matelsky (University of Pennsylvania), Joshua W. Shaevitz (Princeton University), Kanaka Rajan (Harvard Medical School), Konrad P Kording (University of Pennsylvania), Konstantinos Kagias (MIT), Manuel Zimmer (University of Vienna), Michael A Skuhersky (MIT), Miriam B Goodman (Stanford University), Monika Scholz (Max Planck Institute for Neurobiology of Behavior), Netta Cohen (University of Leeds), Quilee Simeon (MIT), Shawn Lockery (University of Oregon), Steven Flavell (MIT), Talmo D Pereira (Salk Institute), Vineet Tiruvadi (Hume AI), Vivek Venkatachalam (Northeastern University), Yangning Lu (MIT)","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2023-08-12T14:26:38Z","title":"The time is ripe to reverse engineer an entire nervous system: simulating behavior from neural interactions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2308.06578","kind":"arxiv","version":5},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5260ad4f7738f6544dcaeb1d9216cb321842051c2bc86427b1890d02f6933585","target":"record","created_at":"2026-07-05T09:08:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5558a7787baf189a7e0b955fff89d447794453ddf8f183f65c597d27718e6f0d","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2023-08-12T14:26:38Z","title_canon_sha256":"71f7164be1f3db8a4542a5c90e430eb71b78b2054c4d89c4dcb921c55a79366f"},"schema_version":"1.0","source":{"id":"2308.06578","kind":"arxiv","version":5}},"canonical_sha256":"d8fc710b48b6d4ccce5ad7c4fea78c654a0f203be0e275c6f4a84685c1526d27","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d8fc710b48b6d4ccce5ad7c4fea78c654a0f203be0e275c6f4a84685c1526d27","first_computed_at":"2026-07-05T09:08:45.477621Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:08:45.477621Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"tbjUfew76BGnt0/FmzzB6MGga7djB8w3FTeJKoffY493L+Q82dH9wOLZ9Sk3lCBuoeMijsItTTO9sfaJ8wGnBg==","signature_status":"signed_v1","signed_at":"2026-07-05T09:08:45.478177Z","signed_message":"canonical_sha256_bytes"},"source_id":"2308.06578","source_kind":"arxiv","source_version":5}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5260ad4f7738f6544dcaeb1d9216cb321842051c2bc86427b1890d02f6933585","sha256:a6e5a7a2404c9db1ac027e65c3ac1c9f277fb32c04ebb0e3d8817d4a15dc16a3"],"state_sha256":"647b1e8d0004ff33278270f112a7b8c6087daf136f719f1eefae3b001575f425"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"BTYeSiUvGde0cVTvPbzXCA/lk6W2kbb80/G808TqaGr3ayygQ6tvpYrDW/sYjuxfCSaBrIxwG+cYy30eBQ3xAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-13T10:45:44.897693Z","bundle_sha256":"e3cdecb71a1e906021cc5ad741d848cbfa18d36566aa1ba666a1e8de3d43518c"}}