{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:3DYAAEM6NMYKZ3QTKXZZK2OQGZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"691ca9ff7287863069712d14fe1519dca6c14652f7e85aab9711adc158126b81","cross_cats_sorted":["cond-mat.stat-mech"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-07-12T00:08:59Z","title_canon_sha256":"fc74504382f1518f98528ede80243c7c749ab98d64b392e9ab5f6ae586b7544a"},"schema_version":"1.0","source":{"id":"2407.08899","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2407.08899","created_at":"2026-06-26T00:15:21Z"},{"alias_kind":"arxiv_version","alias_value":"2407.08899v2","created_at":"2026-06-26T00:15:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2407.08899","created_at":"2026-06-26T00:15:21Z"},{"alias_kind":"pith_short_12","alias_value":"3DYAAEM6NMYK","created_at":"2026-06-26T00:15:21Z"},{"alias_kind":"pith_short_16","alias_value":"3DYAAEM6NMYKZ3QT","created_at":"2026-06-26T00:15:21Z"},{"alias_kind":"pith_short_8","alias_value":"3DYAAEM6","created_at":"2026-06-26T00:15:21Z"}],"graph_snapshots":[{"event_id":"sha256:c779f561f2853ba3333df673cc375bd57d7d472ef4a9383e0b37c1b36caf0695","target":"graph","created_at":"2026-06-26T00:15:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2407.08899/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Investigating the dynamics of chromatin loci and the factors that influence them provides valuable insights into the organization and functionality of the genome within the cell nucleus. We control the expression of Lamin-A, an important organizer of chromatin and nuclear structure. By simultaneously tracking hundreds of telomeres in Lamin-A knocked-out (KO) and wild-type (WT) nuclei, we find that telomere motion in Lamin-A depleted cells is both faster and more directed on micrometer scales, comparable to the size of chromosome territories. In contrast, telomere trajectories in WT cells exhib","authors_text":"E. Barkai, M. Hidalgo-Soria, S. Burov, W. Nicola, Y. Garini, Y. Haddad","cross_cats":["cond-mat.stat-mech"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-07-12T00:08:59Z","title":"Telomeres in Lamin-A Depleted Cells Exhibit Directed Motion and Dynamic Coherence"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2407.08899","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ea29faa714fc97e8b74904796d8bf2ed5218a539ac987fabcce13d0010f207da","target":"record","created_at":"2026-06-26T00:15:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"691ca9ff7287863069712d14fe1519dca6c14652f7e85aab9711adc158126b81","cross_cats_sorted":["cond-mat.stat-mech"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-07-12T00:08:59Z","title_canon_sha256":"fc74504382f1518f98528ede80243c7c749ab98d64b392e9ab5f6ae586b7544a"},"schema_version":"1.0","source":{"id":"2407.08899","kind":"arxiv","version":2}},"canonical_sha256":"d8f000119e6b30acee1355f39569d0364cfb0959bdacb2d75a8ac877294c5812","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d8f000119e6b30acee1355f39569d0364cfb0959bdacb2d75a8ac877294c5812","first_computed_at":"2026-06-26T00:15:21.640005Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-26T00:15:21.640005Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bvW80FADQJdSrgVFDM6D9Or8y1KekUtPXvUFzaR/ljrzBnTyZrb9d2eeKA94PhlznZcBqAcXpkJSqf0MGw5+CA==","signature_status":"signed_v1","signed_at":"2026-06-26T00:15:21.640478Z","signed_message":"canonical_sha256_bytes"},"source_id":"2407.08899","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ea29faa714fc97e8b74904796d8bf2ed5218a539ac987fabcce13d0010f207da","sha256:c779f561f2853ba3333df673cc375bd57d7d472ef4a9383e0b37c1b36caf0695"],"state_sha256":"e12d7e2e925bd0c4a324e0babbda0e5e228f138388da225a23b9378da0addaff"}