{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:53EJREJPDYCRMQ3RRIUWYWLTWQ","short_pith_number":"pith:53EJREJP","canonical_record":{"source":{"id":"1904.12684","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-29T13:09:15Z","cross_cats_sorted":[],"title_canon_sha256":"26fc3f507e8a0e4cb4feb6a98346184f43327bf32ecbb968982a808b7f651ba9","abstract_canon_sha256":"ce1cd6ce136124e059601642b7b93213cbd4c63979c42cd8b0fdcb96607b2f8c"},"schema_version":"1.0"},"canonical_sha256":"eec898912f1e051643718a296c5973b426167ae6b44f7d5d8bd45d76ec87de8c","source":{"kind":"arxiv","id":"1904.12684","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.12684","created_at":"2026-05-17T23:47:34Z"},{"alias_kind":"arxiv_version","alias_value":"1904.12684v1","created_at":"2026-05-17T23:47:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.12684","created_at":"2026-05-17T23:47:34Z"},{"alias_kind":"pith_short_12","alias_value":"53EJREJPDYCR","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"53EJREJPDYCRMQ3R","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"53EJREJP","created_at":"2026-05-18T12:33:10Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:53EJREJPDYCRMQ3RRIUWYWLTWQ","target":"record","payload":{"canonical_record":{"source":{"id":"1904.12684","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-29T13:09:15Z","cross_cats_sorted":[],"title_canon_sha256":"26fc3f507e8a0e4cb4feb6a98346184f43327bf32ecbb968982a808b7f651ba9","abstract_canon_sha256":"ce1cd6ce136124e059601642b7b93213cbd4c63979c42cd8b0fdcb96607b2f8c"},"schema_version":"1.0"},"canonical_sha256":"eec898912f1e051643718a296c5973b426167ae6b44f7d5d8bd45d76ec87de8c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:47:34.356645Z","signature_b64":"ShalyinRPR6Z85QO8fm5ym9gnOWqIqv1TXZUqS5PeiOZim6Uc9bfZK0YibSkYT3ZazAZJMgMNPNCTq7ky6LuAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"eec898912f1e051643718a296c5973b426167ae6b44f7d5d8bd45d76ec87de8c","last_reissued_at":"2026-05-17T23:47:34.356103Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:47:34.356103Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1904.12684","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:47:34Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"GIRsBsZZdMzqsOpDQYepgwFERmwht9iimH6YYY+ii2vtXayiMi9l6fxPF2OQaYtpDwqqnIfhAv8o7wPNi2KeBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-28T06:14:47.904845Z"},"content_sha256":"c72632844ce0e710875a1a3a3074fd9f361f07d0ddb4f99ebe04304ae68a2bff","schema_version":"1.0","event_id":"sha256:c72632844ce0e710875a1a3a3074fd9f361f07d0ddb4f99ebe04304ae68a2bff"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:53EJREJPDYCRMQ3RRIUWYWLTWQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Human Spermbots for Cancer-Relevant Drug Delivery","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"Carla Ribeiro, Christine K. Schmidt, Daniel R. Brison, Elkin Lucena, Haifeng Xu, Kang Zeng, Lina P. Restrepo, Louisa Nelson, Mariana Medina-Sanchez, Oliver G. Schmidt, Richard J. Edmondson, Stephen S. Taylor, Steven Bagley","submitted_at":"2019-04-29T13:09:15Z","abstract_excerpt":"Cellular micromotors are attractive for locally delivering high concentrations of drug and targeting hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means. Spermatozoa are highly efficient micromotors perfectly adapted to traveling up the female reproductive system. Indeed, bovine sperm-based micromotors have recently been reported as a potential candidate for the drug delivery toward gynecological cancers of clinical unmet need. However, due to major differences in the molecular make-up of bovine and human sperm, a key translational bottlen"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.12684","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:47:34Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"qYoE1BONBKevovDhMJ9HTiHhtp864dyNFTRiIygWurPPWEiVNYsTJhPq5lWedg4D3/Zfy38hkGYHL8gIl99QBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-28T06:14:47.905189Z"},"content_sha256":"0012714eeceace492b4c10597a7ca0c6a544c2cb9fa75475f5b3bad551eebd00","schema_version":"1.0","event_id":"sha256:0012714eeceace492b4c10597a7ca0c6a544c2cb9fa75475f5b3bad551eebd00"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/53EJREJPDYCRMQ3RRIUWYWLTWQ/bundle.json","state_url":"https://pith.science/pith/53EJREJPDYCRMQ3RRIUWYWLTWQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/53EJREJPDYCRMQ3RRIUWYWLTWQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-28T06:14:47Z","links":{"resolver":"https://pith.science/pith/53EJREJPDYCRMQ3RRIUWYWLTWQ","bundle":"https://pith.science/pith/53EJREJPDYCRMQ3RRIUWYWLTWQ/bundle.json","state":"https://pith.science/pith/53EJREJPDYCRMQ3RRIUWYWLTWQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/53EJREJPDYCRMQ3RRIUWYWLTWQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:53EJREJPDYCRMQ3RRIUWYWLTWQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ce1cd6ce136124e059601642b7b93213cbd4c63979c42cd8b0fdcb96607b2f8c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-29T13:09:15Z","title_canon_sha256":"26fc3f507e8a0e4cb4feb6a98346184f43327bf32ecbb968982a808b7f651ba9"},"schema_version":"1.0","source":{"id":"1904.12684","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.12684","created_at":"2026-05-17T23:47:34Z"},{"alias_kind":"arxiv_version","alias_value":"1904.12684v1","created_at":"2026-05-17T23:47:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.12684","created_at":"2026-05-17T23:47:34Z"},{"alias_kind":"pith_short_12","alias_value":"53EJREJPDYCR","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"53EJREJPDYCRMQ3R","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"53EJREJP","created_at":"2026-05-18T12:33:10Z"}],"graph_snapshots":[{"event_id":"sha256:0012714eeceace492b4c10597a7ca0c6a544c2cb9fa75475f5b3bad551eebd00","target":"graph","created_at":"2026-05-17T23:47:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cellular micromotors are attractive for locally delivering high concentrations of drug and targeting hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means. Spermatozoa are highly efficient micromotors perfectly adapted to traveling up the female reproductive system. Indeed, bovine sperm-based micromotors have recently been reported as a potential candidate for the drug delivery toward gynecological cancers of clinical unmet need. However, due to major differences in the molecular make-up of bovine and human sperm, a key translational bottlen","authors_text":"Carla Ribeiro, Christine K. Schmidt, Daniel R. Brison, Elkin Lucena, Haifeng Xu, Kang Zeng, Lina P. Restrepo, Louisa Nelson, Mariana Medina-Sanchez, Oliver G. Schmidt, Richard J. Edmondson, Stephen S. Taylor, Steven Bagley","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-29T13:09:15Z","title":"Human Spermbots for Cancer-Relevant Drug Delivery"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.12684","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c72632844ce0e710875a1a3a3074fd9f361f07d0ddb4f99ebe04304ae68a2bff","target":"record","created_at":"2026-05-17T23:47:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ce1cd6ce136124e059601642b7b93213cbd4c63979c42cd8b0fdcb96607b2f8c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2019-04-29T13:09:15Z","title_canon_sha256":"26fc3f507e8a0e4cb4feb6a98346184f43327bf32ecbb968982a808b7f651ba9"},"schema_version":"1.0","source":{"id":"1904.12684","kind":"arxiv","version":1}},"canonical_sha256":"eec898912f1e051643718a296c5973b426167ae6b44f7d5d8bd45d76ec87de8c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"eec898912f1e051643718a296c5973b426167ae6b44f7d5d8bd45d76ec87de8c","first_computed_at":"2026-05-17T23:47:34.356103Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:47:34.356103Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ShalyinRPR6Z85QO8fm5ym9gnOWqIqv1TXZUqS5PeiOZim6Uc9bfZK0YibSkYT3ZazAZJMgMNPNCTq7ky6LuAA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:47:34.356645Z","signed_message":"canonical_sha256_bytes"},"source_id":"1904.12684","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c72632844ce0e710875a1a3a3074fd9f361f07d0ddb4f99ebe04304ae68a2bff","sha256:0012714eeceace492b4c10597a7ca0c6a544c2cb9fa75475f5b3bad551eebd00"],"state_sha256":"e73c349f42d4f7c76af2cec904a95e3f3b22e55bdf751f46b458320cd584438a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QazeLYevOzao6FN2vBqcIYniBGlq2jwpa4cT4ZpCcTYF8WYti8wiL26nipvlGfgNX1iZ2n/WvXP4Q0B/lx8TBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-28T06:14:47.907252Z","bundle_sha256":"e923938284f6a34b47667757aaf2b24c03143f5cc7dffaa5db6da251565c64ba"}}