{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:5FPBITV4IMA65KXS3P6M2C55DQ","short_pith_number":"pith:5FPBITV4","canonical_record":{"source":{"id":"2501.08827","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-01-15T14:28:57Z","cross_cats_sorted":[],"title_canon_sha256":"6f343676b6bb6b0c72ea6ae4560ff98897ca8944d5cdeba8281b155e15f0cb6f","abstract_canon_sha256":"5a1061936082562ab292a8aaceabe6f0ab7cf4edd24f42cb2a4cdd61c773b712"},"schema_version":"1.0"},"canonical_sha256":"e95e144ebc4301eeaaf2dbfccd0bbd1c337cceee175e70701f33a843d92de9e4","source":{"kind":"arxiv","id":"2501.08827","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2501.08827","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"arxiv_version","alias_value":"2501.08827v1","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2501.08827","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"pith_short_12","alias_value":"5FPBITV4IMA6","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"pith_short_16","alias_value":"5FPBITV4IMA65KXS","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"pith_short_8","alias_value":"5FPBITV4","created_at":"2026-07-05T10:01:26Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:5FPBITV4IMA65KXS3P6M2C55DQ","target":"record","payload":{"canonical_record":{"source":{"id":"2501.08827","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-01-15T14:28:57Z","cross_cats_sorted":[],"title_canon_sha256":"6f343676b6bb6b0c72ea6ae4560ff98897ca8944d5cdeba8281b155e15f0cb6f","abstract_canon_sha256":"5a1061936082562ab292a8aaceabe6f0ab7cf4edd24f42cb2a4cdd61c773b712"},"schema_version":"1.0"},"canonical_sha256":"e95e144ebc4301eeaaf2dbfccd0bbd1c337cceee175e70701f33a843d92de9e4","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:01:26.781902Z","signature_b64":"1iSfhWcN8vO19MVJfMqf6jebtIJOS6+3n7XrP0wHZCsDb16roaJIYZiTM/xDD+WEftj6ROEh0VJw9Ej7fCqvCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e95e144ebc4301eeaaf2dbfccd0bbd1c337cceee175e70701f33a843d92de9e4","last_reissued_at":"2026-07-05T10:01:26.781421Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:01:26.781421Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2501.08827","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:01:26Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2LFPztzkIjZiOs39VqfX1fJfk32mx4qZa/FLAd+Vtwq4UeqDolTdCS4vJN19rtb2esmKprY6xIGP7ZQAZvBAAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T11:33:16.952267Z"},"content_sha256":"2106164e6c291405ddb24313c2e4b6a16cc93aeac8c9ca8a9c5ea3bf9a34bc44","schema_version":"1.0","event_id":"sha256:2106164e6c291405ddb24313c2e4b6a16cc93aeac8c9ca8a9c5ea3bf9a34bc44"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:5FPBITV4IMA65KXS3P6M2C55DQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"CHEmical-shift selective Adiabatic Pulse (CHEAP): Fast and High Resolution Downfield 3D 1H-MRSI at 7T","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Arsany Hakim, Guodong Weng, Irena Zubak, Johannes Kaesmacher, Johannes Slotboom, Piotr Radojewski, Sulaiman Sheriff","submitted_at":"2025-01-15T14:28:57Z","abstract_excerpt":"The key molecules such as triphosphate (ATP), glutathione (GSH), and homocarnosine (hCs) - central to metabolic processes in the human brain remain elusive or challenging to detect with upfield 1H-MRSI. Traditional 3D 1H-MRSI in vivo faces challenges, including a low signal-to-noise ratio and magnetization transfer effects with water, leading to prolonged measurement times and reduced resolution. To address these limitations, we propose a downfield 3D-MRSI method aimed at measuring downfield metabolites with enhanced spatial resolution, and speed acceptable for clinical practice at 7T. The CHE"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2501.08827","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2501.08827/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:01:26Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"GWZTEVWFo3cJqiNLMqNorh6LF4mdi+2OxrsCE7C08BX0WEmdFyYroOl1DJrVE1v7D6FaoFutHVVGx7VkXdXfBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T11:33:16.952647Z"},"content_sha256":"88c5983730b20d12158c3eaf3e4a2c4d5979dc8876ba3e6949c47fea63e2efb2","schema_version":"1.0","event_id":"sha256:88c5983730b20d12158c3eaf3e4a2c4d5979dc8876ba3e6949c47fea63e2efb2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5FPBITV4IMA65KXS3P6M2C55DQ/bundle.json","state_url":"https://pith.science/pith/5FPBITV4IMA65KXS3P6M2C55DQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5FPBITV4IMA65KXS3P6M2C55DQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-07T11:33:16Z","links":{"resolver":"https://pith.science/pith/5FPBITV4IMA65KXS3P6M2C55DQ","bundle":"https://pith.science/pith/5FPBITV4IMA65KXS3P6M2C55DQ/bundle.json","state":"https://pith.science/pith/5FPBITV4IMA65KXS3P6M2C55DQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5FPBITV4IMA65KXS3P6M2C55DQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:5FPBITV4IMA65KXS3P6M2C55DQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5a1061936082562ab292a8aaceabe6f0ab7cf4edd24f42cb2a4cdd61c773b712","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-01-15T14:28:57Z","title_canon_sha256":"6f343676b6bb6b0c72ea6ae4560ff98897ca8944d5cdeba8281b155e15f0cb6f"},"schema_version":"1.0","source":{"id":"2501.08827","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2501.08827","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"arxiv_version","alias_value":"2501.08827v1","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2501.08827","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"pith_short_12","alias_value":"5FPBITV4IMA6","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"pith_short_16","alias_value":"5FPBITV4IMA65KXS","created_at":"2026-07-05T10:01:26Z"},{"alias_kind":"pith_short_8","alias_value":"5FPBITV4","created_at":"2026-07-05T10:01:26Z"}],"graph_snapshots":[{"event_id":"sha256:88c5983730b20d12158c3eaf3e4a2c4d5979dc8876ba3e6949c47fea63e2efb2","target":"graph","created_at":"2026-07-05T10:01:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2501.08827/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The key molecules such as triphosphate (ATP), glutathione (GSH), and homocarnosine (hCs) - central to metabolic processes in the human brain remain elusive or challenging to detect with upfield 1H-MRSI. Traditional 3D 1H-MRSI in vivo faces challenges, including a low signal-to-noise ratio and magnetization transfer effects with water, leading to prolonged measurement times and reduced resolution. To address these limitations, we propose a downfield 3D-MRSI method aimed at measuring downfield metabolites with enhanced spatial resolution, and speed acceptable for clinical practice at 7T. The CHE","authors_text":"Arsany Hakim, Guodong Weng, Irena Zubak, Johannes Kaesmacher, Johannes Slotboom, Piotr Radojewski, Sulaiman Sheriff","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-01-15T14:28:57Z","title":"CHEmical-shift selective Adiabatic Pulse (CHEAP): Fast and High Resolution Downfield 3D 1H-MRSI at 7T"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2501.08827","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2106164e6c291405ddb24313c2e4b6a16cc93aeac8c9ca8a9c5ea3bf9a34bc44","target":"record","created_at":"2026-07-05T10:01:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5a1061936082562ab292a8aaceabe6f0ab7cf4edd24f42cb2a4cdd61c773b712","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-01-15T14:28:57Z","title_canon_sha256":"6f343676b6bb6b0c72ea6ae4560ff98897ca8944d5cdeba8281b155e15f0cb6f"},"schema_version":"1.0","source":{"id":"2501.08827","kind":"arxiv","version":1}},"canonical_sha256":"e95e144ebc4301eeaaf2dbfccd0bbd1c337cceee175e70701f33a843d92de9e4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e95e144ebc4301eeaaf2dbfccd0bbd1c337cceee175e70701f33a843d92de9e4","first_computed_at":"2026-07-05T10:01:26.781421Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:01:26.781421Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"1iSfhWcN8vO19MVJfMqf6jebtIJOS6+3n7XrP0wHZCsDb16roaJIYZiTM/xDD+WEftj6ROEh0VJw9Ej7fCqvCA==","signature_status":"signed_v1","signed_at":"2026-07-05T10:01:26.781902Z","signed_message":"canonical_sha256_bytes"},"source_id":"2501.08827","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2106164e6c291405ddb24313c2e4b6a16cc93aeac8c9ca8a9c5ea3bf9a34bc44","sha256:88c5983730b20d12158c3eaf3e4a2c4d5979dc8876ba3e6949c47fea63e2efb2"],"state_sha256":"d48464725cc340589c76231fc9687eb077eddf28b79f79dd5adb7a098cd72222"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9LNH0eiI9pI/4rOpXNp7nPK9bA91BTWoJf4QaOU5VRIOjyNLQ1UTEga1f0q8+SqNKSxP84JBpGb1OklKe5GjCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-07T11:33:16.954568Z","bundle_sha256":"71e8835e3071825bc2285f59a3f0936aa88ade3d96225dde3f9f1dbd8843fc68"}}