{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:5H5MLZGUZJMEXRQLNACJMTXDSM","short_pith_number":"pith:5H5MLZGU","canonical_record":{"source":{"id":"1702.00351","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2017-02-01T16:54:23Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"842ac13bebb0d0dc79328ba405ec2462c4929eba78329fea23b0cc8b3069b15a","abstract_canon_sha256":"03e6ec11c61d3c0734700f8d92965cafc2376acfbd32dacb75f057666a6b1924"},"schema_version":"1.0"},"canonical_sha256":"e9fac5e4d4ca584bc60b6804964ee3931f19352245a55d4674267a6b3e39d188","source":{"kind":"arxiv","id":"1702.00351","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1702.00351","created_at":"2026-05-18T00:46:07Z"},{"alias_kind":"arxiv_version","alias_value":"1702.00351v2","created_at":"2026-05-18T00:46:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1702.00351","created_at":"2026-05-18T00:46:07Z"},{"alias_kind":"pith_short_12","alias_value":"5H5MLZGUZJME","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_16","alias_value":"5H5MLZGUZJMEXRQL","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_8","alias_value":"5H5MLZGU","created_at":"2026-05-18T12:31:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:5H5MLZGUZJMEXRQLNACJMTXDSM","target":"record","payload":{"canonical_record":{"source":{"id":"1702.00351","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2017-02-01T16:54:23Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"842ac13bebb0d0dc79328ba405ec2462c4929eba78329fea23b0cc8b3069b15a","abstract_canon_sha256":"03e6ec11c61d3c0734700f8d92965cafc2376acfbd32dacb75f057666a6b1924"},"schema_version":"1.0"},"canonical_sha256":"e9fac5e4d4ca584bc60b6804964ee3931f19352245a55d4674267a6b3e39d188","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:46:07.624495Z","signature_b64":"cbfXfdygDLJcO/0oMYuVCPopQ/UgCbwkAjB53j168/MNZaZ5bpaap1ToaF5TXQLaqsL+XmJBFFzHvEK4rWGnDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e9fac5e4d4ca584bc60b6804964ee3931f19352245a55d4674267a6b3e39d188","last_reissued_at":"2026-05-18T00:46:07.624007Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:46:07.624007Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1702.00351","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:46:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"wOaWBtSwFK4h+oqILzr9g4D2RsTBPVTAAVMpTAWdQR+jcdqoPyeYLM+D/oxWv9fr4pLES4gmlOzeTtU3pZa1Aw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T16:21:17.211083Z"},"content_sha256":"0bf0880d294e361c448f72b5f4163d7568a37784a5808e5f7f1bebc6536dc628","schema_version":"1.0","event_id":"sha256:0bf0880d294e361c448f72b5f4163d7568a37784a5808e5f7f1bebc6536dc628"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:5H5MLZGUZJMEXRQLNACJMTXDSM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Distribution of phenotype sizes in sequence-to-structure genotype-phenotype maps","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.PE","authors_text":"Jose A. Cuesta, Susanna Manrubia","submitted_at":"2017-02-01T16:54:23Z","abstract_excerpt":"An essential quantity to ensure evolvability of populations is the navigability of the genotype space. Navigability relies on the existence of sufficiently large genotype networks, that is ensembles of sequences with the same phenotype that guarantee an efficient random drift through sequence space. The number of sequences compatible with a given structure (e.g. the number of RNA sequences folding into a particular secondary structure, or the number of DNA sequences coding for the same protein structure) is astronomically large in all functional molecules investigated. However, an exhaustive e"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1702.00351","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:46:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"XpTl5o4bqcJoeGFft3waHV8oqP72TgxYb5mUZJ7j2ttQx//8Rjnyatr8fyxVMi+d332kDS85ppOrWJl99k+ABg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T16:21:17.211473Z"},"content_sha256":"fc62443924e622981f44894fa4027c780d74cc4739b0543fee7e5a64be917ea2","schema_version":"1.0","event_id":"sha256:fc62443924e622981f44894fa4027c780d74cc4739b0543fee7e5a64be917ea2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5H5MLZGUZJMEXRQLNACJMTXDSM/bundle.json","state_url":"https://pith.science/pith/5H5MLZGUZJMEXRQLNACJMTXDSM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5H5MLZGUZJMEXRQLNACJMTXDSM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-23T16:21:17Z","links":{"resolver":"https://pith.science/pith/5H5MLZGUZJMEXRQLNACJMTXDSM","bundle":"https://pith.science/pith/5H5MLZGUZJMEXRQLNACJMTXDSM/bundle.json","state":"https://pith.science/pith/5H5MLZGUZJMEXRQLNACJMTXDSM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5H5MLZGUZJMEXRQLNACJMTXDSM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:5H5MLZGUZJMEXRQLNACJMTXDSM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"03e6ec11c61d3c0734700f8d92965cafc2376acfbd32dacb75f057666a6b1924","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2017-02-01T16:54:23Z","title_canon_sha256":"842ac13bebb0d0dc79328ba405ec2462c4929eba78329fea23b0cc8b3069b15a"},"schema_version":"1.0","source":{"id":"1702.00351","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1702.00351","created_at":"2026-05-18T00:46:07Z"},{"alias_kind":"arxiv_version","alias_value":"1702.00351v2","created_at":"2026-05-18T00:46:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1702.00351","created_at":"2026-05-18T00:46:07Z"},{"alias_kind":"pith_short_12","alias_value":"5H5MLZGUZJME","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_16","alias_value":"5H5MLZGUZJMEXRQL","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_8","alias_value":"5H5MLZGU","created_at":"2026-05-18T12:31:00Z"}],"graph_snapshots":[{"event_id":"sha256:fc62443924e622981f44894fa4027c780d74cc4739b0543fee7e5a64be917ea2","target":"graph","created_at":"2026-05-18T00:46:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"An essential quantity to ensure evolvability of populations is the navigability of the genotype space. Navigability relies on the existence of sufficiently large genotype networks, that is ensembles of sequences with the same phenotype that guarantee an efficient random drift through sequence space. The number of sequences compatible with a given structure (e.g. the number of RNA sequences folding into a particular secondary structure, or the number of DNA sequences coding for the same protein structure) is astronomically large in all functional molecules investigated. However, an exhaustive e","authors_text":"Jose A. Cuesta, Susanna Manrubia","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2017-02-01T16:54:23Z","title":"Distribution of phenotype sizes in sequence-to-structure genotype-phenotype maps"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1702.00351","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0bf0880d294e361c448f72b5f4163d7568a37784a5808e5f7f1bebc6536dc628","target":"record","created_at":"2026-05-18T00:46:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"03e6ec11c61d3c0734700f8d92965cafc2376acfbd32dacb75f057666a6b1924","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2017-02-01T16:54:23Z","title_canon_sha256":"842ac13bebb0d0dc79328ba405ec2462c4929eba78329fea23b0cc8b3069b15a"},"schema_version":"1.0","source":{"id":"1702.00351","kind":"arxiv","version":2}},"canonical_sha256":"e9fac5e4d4ca584bc60b6804964ee3931f19352245a55d4674267a6b3e39d188","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e9fac5e4d4ca584bc60b6804964ee3931f19352245a55d4674267a6b3e39d188","first_computed_at":"2026-05-18T00:46:07.624007Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:46:07.624007Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"cbfXfdygDLJcO/0oMYuVCPopQ/UgCbwkAjB53j168/MNZaZ5bpaap1ToaF5TXQLaqsL+XmJBFFzHvEK4rWGnDA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:46:07.624495Z","signed_message":"canonical_sha256_bytes"},"source_id":"1702.00351","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0bf0880d294e361c448f72b5f4163d7568a37784a5808e5f7f1bebc6536dc628","sha256:fc62443924e622981f44894fa4027c780d74cc4739b0543fee7e5a64be917ea2"],"state_sha256":"39b7a9f079cf9fb8f404f9510f811c415bc42334ef853a0fba86a48a9361ac87"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ekypKiz8d8op5QXZ4vnkRhjp1fthlfMQ8IySohLsybz7M0FA4w1HutKJ/nxDBaWkL2ZwNGGxEayDApDectl4DA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-23T16:21:17.213580Z","bundle_sha256":"4a2d11178691e3ff1702a4e9b36b4003f3e011932a2bcf6bf04effd65fb42c2f"}}