{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:66QSNISS72OPI2FJ6ONUTCRE6G","short_pith_number":"pith:66QSNISS","canonical_record":{"source":{"id":"1507.02148","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-07-07T18:09:47Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"288b4ec7dc5fcb14af2c07c64ac4dbd34defac2135c8900a7e0e617a8f0a9f25","abstract_canon_sha256":"c0271741547668101c78f61016be82a146a0fc5dcfd6ab4b2919628133d71b7b"},"schema_version":"1.0"},"canonical_sha256":"f7a126a252fe9cf468a9f39b498a24f1a734857b237bc0c4f4dc9855f942f896","source":{"kind":"arxiv","id":"1507.02148","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1507.02148","created_at":"2026-05-18T01:37:08Z"},{"alias_kind":"arxiv_version","alias_value":"1507.02148v1","created_at":"2026-05-18T01:37:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1507.02148","created_at":"2026-05-18T01:37:08Z"},{"alias_kind":"pith_short_12","alias_value":"66QSNISS72OP","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_16","alias_value":"66QSNISS72OPI2FJ","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_8","alias_value":"66QSNISS","created_at":"2026-05-18T12:29:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:66QSNISS72OPI2FJ6ONUTCRE6G","target":"record","payload":{"canonical_record":{"source":{"id":"1507.02148","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-07-07T18:09:47Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"288b4ec7dc5fcb14af2c07c64ac4dbd34defac2135c8900a7e0e617a8f0a9f25","abstract_canon_sha256":"c0271741547668101c78f61016be82a146a0fc5dcfd6ab4b2919628133d71b7b"},"schema_version":"1.0"},"canonical_sha256":"f7a126a252fe9cf468a9f39b498a24f1a734857b237bc0c4f4dc9855f942f896","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:37:08.520540Z","signature_b64":"XkGqItEjef6I7VqfhKG3y+wAfiLe/HiYKXYeU29RjfoBtTlUvRW5cgRnCJcu/b9OryMlhCLF5lp1XSB46+GYBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f7a126a252fe9cf468a9f39b498a24f1a734857b237bc0c4f4dc9855f942f896","last_reissued_at":"2026-05-18T01:37:08.519894Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:37:08.519894Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1507.02148","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:37:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"oMCIt1lGt4Co1Kg5eNEqLX+fFioT+/0qNouhRmj4YfUpowe1yrgLpNLqTuKyc7pp9MwYR0Q4YWXhFx9/V3SMDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-20T05:42:04.350780Z"},"content_sha256":"cf320ff131ff6eebe78f0590c3a6b350b11445063e8fbd5ad105128a92febb83","schema_version":"1.0","event_id":"sha256:cf320ff131ff6eebe78f0590c3a6b350b11445063e8fbd5ad105128a92febb83"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:66QSNISS72OPI2FJ6ONUTCRE6G","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Derivative-free optimization of rate parameters of capsid assembly models from bulk in vitro data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.QM","authors_text":"Gregory R. Smith, Lu Xie, Russell Schwartz","submitted_at":"2015-07-07T18:09:47Z","abstract_excerpt":"The assembly of virus capsids from free coat proteins proceeds by a complicated cascade of association and dissociation steps, the great majority of which cannot be directly experimentally observed. This has made capsid assembly a rich field for computational models to attempt to fill the gaps in what is experimentally observable. Nonetheless, accurate simulation predictions depend on accurate models and there are substantial obstacles to model inference for such systems. Here, we describe progress in learning parameters for capsid assembly systems, particularly kinetic rate constants of coat-"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1507.02148","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:37:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jvoFg22leGzYTrFZgjkVYaW8r6kxC8koiHzakd6lsAseX/9vTQxiTH3eGdwq8luIMjGIUkRx2mJ/vJKIbN/YDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-20T05:42:04.351127Z"},"content_sha256":"0615c19c6b1535b50bf5dd88f50c81dbe8a6dc7329e3b48dfbbbbc9db7cc10d3","schema_version":"1.0","event_id":"sha256:0615c19c6b1535b50bf5dd88f50c81dbe8a6dc7329e3b48dfbbbbc9db7cc10d3"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/66QSNISS72OPI2FJ6ONUTCRE6G/bundle.json","state_url":"https://pith.science/pith/66QSNISS72OPI2FJ6ONUTCRE6G/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/66QSNISS72OPI2FJ6ONUTCRE6G/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-20T05:42:04Z","links":{"resolver":"https://pith.science/pith/66QSNISS72OPI2FJ6ONUTCRE6G","bundle":"https://pith.science/pith/66QSNISS72OPI2FJ6ONUTCRE6G/bundle.json","state":"https://pith.science/pith/66QSNISS72OPI2FJ6ONUTCRE6G/state.json","well_known_bundle":"https://pith.science/.well-known/pith/66QSNISS72OPI2FJ6ONUTCRE6G/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:66QSNISS72OPI2FJ6ONUTCRE6G","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c0271741547668101c78f61016be82a146a0fc5dcfd6ab4b2919628133d71b7b","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-07-07T18:09:47Z","title_canon_sha256":"288b4ec7dc5fcb14af2c07c64ac4dbd34defac2135c8900a7e0e617a8f0a9f25"},"schema_version":"1.0","source":{"id":"1507.02148","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1507.02148","created_at":"2026-05-18T01:37:08Z"},{"alias_kind":"arxiv_version","alias_value":"1507.02148v1","created_at":"2026-05-18T01:37:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1507.02148","created_at":"2026-05-18T01:37:08Z"},{"alias_kind":"pith_short_12","alias_value":"66QSNISS72OP","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_16","alias_value":"66QSNISS72OPI2FJ","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_8","alias_value":"66QSNISS","created_at":"2026-05-18T12:29:07Z"}],"graph_snapshots":[{"event_id":"sha256:0615c19c6b1535b50bf5dd88f50c81dbe8a6dc7329e3b48dfbbbbc9db7cc10d3","target":"graph","created_at":"2026-05-18T01:37:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The assembly of virus capsids from free coat proteins proceeds by a complicated cascade of association and dissociation steps, the great majority of which cannot be directly experimentally observed. This has made capsid assembly a rich field for computational models to attempt to fill the gaps in what is experimentally observable. Nonetheless, accurate simulation predictions depend on accurate models and there are substantial obstacles to model inference for such systems. Here, we describe progress in learning parameters for capsid assembly systems, particularly kinetic rate constants of coat-","authors_text":"Gregory R. Smith, Lu Xie, Russell Schwartz","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-07-07T18:09:47Z","title":"Derivative-free optimization of rate parameters of capsid assembly models from bulk in vitro data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1507.02148","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cf320ff131ff6eebe78f0590c3a6b350b11445063e8fbd5ad105128a92febb83","target":"record","created_at":"2026-05-18T01:37:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c0271741547668101c78f61016be82a146a0fc5dcfd6ab4b2919628133d71b7b","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-07-07T18:09:47Z","title_canon_sha256":"288b4ec7dc5fcb14af2c07c64ac4dbd34defac2135c8900a7e0e617a8f0a9f25"},"schema_version":"1.0","source":{"id":"1507.02148","kind":"arxiv","version":1}},"canonical_sha256":"f7a126a252fe9cf468a9f39b498a24f1a734857b237bc0c4f4dc9855f942f896","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f7a126a252fe9cf468a9f39b498a24f1a734857b237bc0c4f4dc9855f942f896","first_computed_at":"2026-05-18T01:37:08.519894Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:37:08.519894Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XkGqItEjef6I7VqfhKG3y+wAfiLe/HiYKXYeU29RjfoBtTlUvRW5cgRnCJcu/b9OryMlhCLF5lp1XSB46+GYBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:37:08.520540Z","signed_message":"canonical_sha256_bytes"},"source_id":"1507.02148","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cf320ff131ff6eebe78f0590c3a6b350b11445063e8fbd5ad105128a92febb83","sha256:0615c19c6b1535b50bf5dd88f50c81dbe8a6dc7329e3b48dfbbbbc9db7cc10d3"],"state_sha256":"d651d1f146b659a574589ab0839103c3dc0fd3af073fdb80fbb46de98974005e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Yg5YtK9gwkRmRIl+1uwJusaIqEoQ3I/OyU9PhlwYyV+lKhuHMyUpLRulwGXQUUNnRY1oaELGu2oUaUrv3d1CCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-20T05:42:04.353098Z","bundle_sha256":"6b6489b7c6d431c8becee0ad4a5a1d5bfcbe65aa53409593dd27adc9112f4c3f"}}