{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:6732QEEJOXUTZ4DC7CXPRIK3F6","short_pith_number":"pith:6732QEEJ","canonical_record":{"source":{"id":"1105.1102","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-05-05T15:29:23Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"c47c2529c52fdc8d8a4f6117270dec597e9d240d764bb5a2ae2fa2db780cd967","abstract_canon_sha256":"38ba2bea613000158965eec8a5f8b564b0311bd064cfc715bb9d64ec6a1e3aec"},"schema_version":"1.0"},"canonical_sha256":"f7f7a8108975e93cf062f8aef8a15b2f889aa4f9d9749bc9037ccb525bdee28a","source":{"kind":"arxiv","id":"1105.1102","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.1102","created_at":"2026-05-18T04:22:49Z"},{"alias_kind":"arxiv_version","alias_value":"1105.1102v1","created_at":"2026-05-18T04:22:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.1102","created_at":"2026-05-18T04:22:49Z"},{"alias_kind":"pith_short_12","alias_value":"6732QEEJOXUT","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_16","alias_value":"6732QEEJOXUTZ4DC","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_8","alias_value":"6732QEEJ","created_at":"2026-05-18T12:26:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:6732QEEJOXUTZ4DC7CXPRIK3F6","target":"record","payload":{"canonical_record":{"source":{"id":"1105.1102","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-05-05T15:29:23Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"c47c2529c52fdc8d8a4f6117270dec597e9d240d764bb5a2ae2fa2db780cd967","abstract_canon_sha256":"38ba2bea613000158965eec8a5f8b564b0311bd064cfc715bb9d64ec6a1e3aec"},"schema_version":"1.0"},"canonical_sha256":"f7f7a8108975e93cf062f8aef8a15b2f889aa4f9d9749bc9037ccb525bdee28a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:22:49.241409Z","signature_b64":"JXIjJw0zB6xXp3v56rYdKaBnAnfHNp9N3kGOUZQsrraZpUq5iNJwN2tm/aO25viuvMvvwLPl3iYKvOnkaYqnDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f7f7a8108975e93cf062f8aef8a15b2f889aa4f9d9749bc9037ccb525bdee28a","last_reissued_at":"2026-05-18T04:22:49.240795Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:22:49.240795Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1105.1102","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:22:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"BbRw0kvnMVoyQx0OsF1ixtXc7BhYwKDATotUiZRVYdrJcxG72hUXpQP+gQd2bgnG+OtLQ+pbJe4Dn8VCZniQAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T00:34:10.970641Z"},"content_sha256":"a6f333db2f1ab715a8aa7f56ad4b51e402bda948cf94209384488b9c2cdd8b65","schema_version":"1.0","event_id":"sha256:a6f333db2f1ab715a8aa7f56ad4b51e402bda948cf94209384488b9c2cdd8b65"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:6732QEEJOXUTZ4DC7CXPRIK3F6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"cond-mat.soft","authors_text":"Bernard R. Brooks, D. Thirumalai, Edward P. O'Brien, John E. Straub","submitted_at":"2011-05-05T15:29:23Z","abstract_excerpt":"Understanding the influence of macromolecular crowding and nanoparticles on the formation of in-register $\\beta$-sheets, the primary structural component of amyloid fibrils, is a first step towards describing \\emph{in vivo} protein aggregation and interactions between synthetic materials and proteins. Using all atom molecular simulations in implicit solvent we illustrate the effects of nanoparticle size, shape, and volume fraction on oligomer formation of an amyloidogenic peptide from the transthyretin protein. Surprisingly, we find that inert spherical crowding particles destabilize in-regist"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.1102","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:22:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"EnGwgwA6hCZzyifkkCesLLF4rLicil955jt0+pF00X0jEY0BNMcQZthr3wv1Bcypi6X+j27R83igMgSp05ykBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T00:34:10.970987Z"},"content_sha256":"85f2484de978c35c8527986fa3b4986ee3023631cf1cb938e5ee3e0c38b6dc7a","schema_version":"1.0","event_id":"sha256:85f2484de978c35c8527986fa3b4986ee3023631cf1cb938e5ee3e0c38b6dc7a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/6732QEEJOXUTZ4DC7CXPRIK3F6/bundle.json","state_url":"https://pith.science/pith/6732QEEJOXUTZ4DC7CXPRIK3F6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/6732QEEJOXUTZ4DC7CXPRIK3F6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-24T00:34:10Z","links":{"resolver":"https://pith.science/pith/6732QEEJOXUTZ4DC7CXPRIK3F6","bundle":"https://pith.science/pith/6732QEEJOXUTZ4DC7CXPRIK3F6/bundle.json","state":"https://pith.science/pith/6732QEEJOXUTZ4DC7CXPRIK3F6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/6732QEEJOXUTZ4DC7CXPRIK3F6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:6732QEEJOXUTZ4DC7CXPRIK3F6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"38ba2bea613000158965eec8a5f8b564b0311bd064cfc715bb9d64ec6a1e3aec","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-05-05T15:29:23Z","title_canon_sha256":"c47c2529c52fdc8d8a4f6117270dec597e9d240d764bb5a2ae2fa2db780cd967"},"schema_version":"1.0","source":{"id":"1105.1102","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.1102","created_at":"2026-05-18T04:22:49Z"},{"alias_kind":"arxiv_version","alias_value":"1105.1102v1","created_at":"2026-05-18T04:22:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.1102","created_at":"2026-05-18T04:22:49Z"},{"alias_kind":"pith_short_12","alias_value":"6732QEEJOXUT","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_16","alias_value":"6732QEEJOXUTZ4DC","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_8","alias_value":"6732QEEJ","created_at":"2026-05-18T12:26:22Z"}],"graph_snapshots":[{"event_id":"sha256:85f2484de978c35c8527986fa3b4986ee3023631cf1cb938e5ee3e0c38b6dc7a","target":"graph","created_at":"2026-05-18T04:22:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Understanding the influence of macromolecular crowding and nanoparticles on the formation of in-register $\\beta$-sheets, the primary structural component of amyloid fibrils, is a first step towards describing \\emph{in vivo} protein aggregation and interactions between synthetic materials and proteins. Using all atom molecular simulations in implicit solvent we illustrate the effects of nanoparticle size, shape, and volume fraction on oligomer formation of an amyloidogenic peptide from the transthyretin protein. Surprisingly, we find that inert spherical crowding particles destabilize in-regist","authors_text":"Bernard R. Brooks, D. Thirumalai, Edward P. O'Brien, John E. Straub","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-05-05T15:29:23Z","title":"Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.1102","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a6f333db2f1ab715a8aa7f56ad4b51e402bda948cf94209384488b9c2cdd8b65","target":"record","created_at":"2026-05-18T04:22:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"38ba2bea613000158965eec8a5f8b564b0311bd064cfc715bb9d64ec6a1e3aec","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2011-05-05T15:29:23Z","title_canon_sha256":"c47c2529c52fdc8d8a4f6117270dec597e9d240d764bb5a2ae2fa2db780cd967"},"schema_version":"1.0","source":{"id":"1105.1102","kind":"arxiv","version":1}},"canonical_sha256":"f7f7a8108975e93cf062f8aef8a15b2f889aa4f9d9749bc9037ccb525bdee28a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f7f7a8108975e93cf062f8aef8a15b2f889aa4f9d9749bc9037ccb525bdee28a","first_computed_at":"2026-05-18T04:22:49.240795Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:22:49.240795Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"JXIjJw0zB6xXp3v56rYdKaBnAnfHNp9N3kGOUZQsrraZpUq5iNJwN2tm/aO25viuvMvvwLPl3iYKvOnkaYqnDA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:22:49.241409Z","signed_message":"canonical_sha256_bytes"},"source_id":"1105.1102","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a6f333db2f1ab715a8aa7f56ad4b51e402bda948cf94209384488b9c2cdd8b65","sha256:85f2484de978c35c8527986fa3b4986ee3023631cf1cb938e5ee3e0c38b6dc7a"],"state_sha256":"0d20f7f811358a37ca82242d356bd893d5a9cee14fd856360fe358bc54ec639e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"glhiOMrM7OHUQ125ose3Tn9ExU82LPnIjYSybD6bUL5N/C0ueT0/1krlH+L4RAIttmQiD0WzLJyg04ouVk99DQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-24T00:34:10.972971Z","bundle_sha256":"8cceddae79931c22b8065c02c1ed112882bdb19988738a8e6d0f9bafc5a6f79f"}}