{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:6UQYOBWP2JLMXGJMKFXULJ33WA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f5367f8ea98cb9744ccff1b80ca856f1f5a8bdd792f8bbd6a1f4f246bb61df1f","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-26T02:39:21Z","title_canon_sha256":"fa0de885f6531bfb04c40af3b020301aa4e04497d1bc8ed928550af54ef38074"},"schema_version":"1.0","source":{"id":"1105.5192","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.5192","created_at":"2026-05-18T04:21:13Z"},{"alias_kind":"arxiv_version","alias_value":"1105.5192v1","created_at":"2026-05-18T04:21:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.5192","created_at":"2026-05-18T04:21:13Z"},{"alias_kind":"pith_short_12","alias_value":"6UQYOBWP2JLM","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_16","alias_value":"6UQYOBWP2JLMXGJM","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_8","alias_value":"6UQYOBWP","created_at":"2026-05-18T12:26:22Z"}],"graph_snapshots":[{"event_id":"sha256:e4922f3aa63409b0669815aa456465a65c2c64b332e23951ecc4ee14b30de594","target":"graph","created_at":"2026-05-18T04:21:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We develop a theory of enzyme catalysis within biological cells where the substrate concentration [S](t) is time dependent, in contrast to the Michaelis-Menten theory that assumes a steady state. We find that the time varying concentration can combine, in a non-linear way, with the ruggedness of the free energy landscape of enzymes (discovered both in single molecule studies and in simulations) to provide a highly efficient switch (or, bifurcation) between two catalytically active states, at a critical substrate concentration. This allows a dynamic control of product synthesis in cell.","authors_text":"Biman Bagchi, Biman Jana","cross_cats":["physics.bio-ph","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-26T02:39:21Z","title":"Dynamic control of catalysis within biological cells"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.5192","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:dad7eef65e1c70dbb40d3f21f3104680e5a873f4d454101134ab65174ea61b0e","target":"record","created_at":"2026-05-18T04:21:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f5367f8ea98cb9744ccff1b80ca856f1f5a8bdd792f8bbd6a1f4f246bb61df1f","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-26T02:39:21Z","title_canon_sha256":"fa0de885f6531bfb04c40af3b020301aa4e04497d1bc8ed928550af54ef38074"},"schema_version":"1.0","source":{"id":"1105.5192","kind":"arxiv","version":1}},"canonical_sha256":"f5218706cfd256cb992c516f45a77bb02557c68656892de2afe1d4d9f73a5953","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f5218706cfd256cb992c516f45a77bb02557c68656892de2afe1d4d9f73a5953","first_computed_at":"2026-05-18T04:21:13.040735Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:21:13.040735Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"8TjIYmJUhwxEI4J9947z5HCxguigIJvb2CixCIaV5WCFHQK647iHbZokII2ujsZJ2AnIUAvK0LQa5J9cohpYBw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:21:13.041281Z","signed_message":"canonical_sha256_bytes"},"source_id":"1105.5192","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:dad7eef65e1c70dbb40d3f21f3104680e5a873f4d454101134ab65174ea61b0e","sha256:e4922f3aa63409b0669815aa456465a65c2c64b332e23951ecc4ee14b30de594"],"state_sha256":"7dd0600dfdec4192c94a1d53c3339cbdf2a80b11ed0418bffd2b195b8237d89e"}