{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:7F3Y3YNEA4DVXYAF3HGX7RVFDZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d3374a6ec0ffe0ced04a9dbb470a3749b98c9aea666974b335e826254a38f349","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-04-14T17:42:11Z","title_canon_sha256":"f6c272f4796766c556be917f2eaaf4744de4d696420181199265e8d22e51753e"},"schema_version":"1.0","source":{"id":"1104.2845","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1104.2845","created_at":"2026-05-18T02:22:09Z"},{"alias_kind":"arxiv_version","alias_value":"1104.2845v1","created_at":"2026-05-18T02:22:09Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1104.2845","created_at":"2026-05-18T02:22:09Z"},{"alias_kind":"pith_short_12","alias_value":"7F3Y3YNEA4DV","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_16","alias_value":"7F3Y3YNEA4DVXYAF","created_at":"2026-05-18T12:26:22Z"},{"alias_kind":"pith_short_8","alias_value":"7F3Y3YNE","created_at":"2026-05-18T12:26:22Z"}],"graph_snapshots":[{"event_id":"sha256:41ee0f4dc9d4318a5db3d611cd2a37a5052962b3533a5c4f27edd1fb59d5b2f3","target":"graph","created_at":"2026-05-18T02:22:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing the network topologies that can exhibit bistability remains a challenge, in part due to the exceedingly large variety of GRNs that exist for even a small number of components. We begin to address this problem by employing chemical reaction network theory in a comprehensive in silico survey to determine the capacity for bistability of more than 40,000 simple networks that can be formed by two tra","authors_text":"Dan Siegal-Gaskins, Erich Grotewold, Gregory D. Smith, Maria Katherine Mejia-Guerra","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-04-14T17:42:11Z","title":"Emergence of switch-like behavior in a large family of simple biochemical networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1104.2845","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cf9f9e2f54fda87bfa00706f7cdc631ee6dbe062bc2bcd3bf6654861461e854e","target":"record","created_at":"2026-05-18T02:22:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d3374a6ec0ffe0ced04a9dbb470a3749b98c9aea666974b335e826254a38f349","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-04-14T17:42:11Z","title_canon_sha256":"f6c272f4796766c556be917f2eaaf4744de4d696420181199265e8d22e51753e"},"schema_version":"1.0","source":{"id":"1104.2845","kind":"arxiv","version":1}},"canonical_sha256":"f9778de1a407075be005d9cd7fc6a51e58d2dc0dd9a6fe73fcdea60f038037d6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f9778de1a407075be005d9cd7fc6a51e58d2dc0dd9a6fe73fcdea60f038037d6","first_computed_at":"2026-05-18T02:22:09.143420Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:22:09.143420Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"b9mOMzz1ZrB64F5ZnepL5RiyY+IYGSt8Myqzviz0nrI49/sCuF2US3iLWcdzxjAXh+fZA2iwAk/2tFoldqimCw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:22:09.144088Z","signed_message":"canonical_sha256_bytes"},"source_id":"1104.2845","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cf9f9e2f54fda87bfa00706f7cdc631ee6dbe062bc2bcd3bf6654861461e854e","sha256:41ee0f4dc9d4318a5db3d611cd2a37a5052962b3533a5c4f27edd1fb59d5b2f3"],"state_sha256":"8f909586d402380d3cf90f8e8cdb7b81ee82fa8ca97e09f8e4a986805f936d0f"}