{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:A2VT2I7PA2GGYYJRJQIOXEFNUP","short_pith_number":"pith:A2VT2I7P","canonical_record":{"source":{"id":"1812.04525","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:30:10Z","cross_cats_sorted":[],"title_canon_sha256":"768642d98e86f11baff6b7817b0764c20f5dd76d9d1107eeb58c561f1ae2f2f1","abstract_canon_sha256":"7583ea3f92e380c2f405c306dc5923e5ea9cba39a9d88e5f70d4de9ab21253d0"},"schema_version":"1.0"},"canonical_sha256":"06ab3d23ef068c6c61314c10eb90ada3d9c100337f861157922daca549e51dc7","source":{"kind":"arxiv","id":"1812.04525","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.04525","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"arxiv_version","alias_value":"1812.04525v1","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.04525","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"pith_short_12","alias_value":"A2VT2I7PA2GG","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_16","alias_value":"A2VT2I7PA2GGYYJR","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_8","alias_value":"A2VT2I7P","created_at":"2026-05-18T12:32:13Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:A2VT2I7PA2GGYYJRJQIOXEFNUP","target":"record","payload":{"canonical_record":{"source":{"id":"1812.04525","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:30:10Z","cross_cats_sorted":[],"title_canon_sha256":"768642d98e86f11baff6b7817b0764c20f5dd76d9d1107eeb58c561f1ae2f2f1","abstract_canon_sha256":"7583ea3f92e380c2f405c306dc5923e5ea9cba39a9d88e5f70d4de9ab21253d0"},"schema_version":"1.0"},"canonical_sha256":"06ab3d23ef068c6c61314c10eb90ada3d9c100337f861157922daca549e51dc7","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:58:31.788340Z","signature_b64":"eKiHqJn1COlrSb/1fLQvt8VC9xiSZqca4bP1o5+jOyp+tw7r1Jm9fyZSDJyOiTwXEAIotHpRSZE7j8Rs5q1GCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"06ab3d23ef068c6c61314c10eb90ada3d9c100337f861157922daca549e51dc7","last_reissued_at":"2026-05-17T23:58:31.787695Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:58:31.787695Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1812.04525","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:58:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"e+z8Qx2Yuxz9FHvax4RXQl/Rdckvy/Ug2DhFz0yybpsRINfmVfsSaNWDoEnaQcbuaAF2wwmtN2SgVqfJkBjIBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T15:41:06.267816Z"},"content_sha256":"44ed908f1fd620a3f71b5a4a850615d512d23bee5c2dffc52e5156702a8aa024","schema_version":"1.0","event_id":"sha256:44ed908f1fd620a3f71b5a4a850615d512d23bee5c2dffc52e5156702a8aa024"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:A2VT2I7PA2GGYYJRJQIOXEFNUP","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Observability and Structural Identifiability of Nonlinear Biological Systems","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Alejandro F. Villaverde","submitted_at":"2018-12-11T16:30:10Z","abstract_excerpt":"Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of determining the parameter values from the output. In fact, structural identifiability becomes a particular case of observability if the parameters are considered as constant state variables. It is possible to simultaneously analyse the observability and structural identifiability of a model using the conceptual tools of differential geometry. Many complex biologi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.04525","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:58:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"R/UnHp5PeVr3Zx8qTnUxQmR4CEFXxq1URuhjyiNS0JVmwFKLCOx5rjpgrIExXd+Youw0oyFXaevdRO9xKlH9CA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T15:41:06.268159Z"},"content_sha256":"5f39b38a013e0cd1ce21144a75f7357982c56c261de512d9887a6ab2f6b6bbf5","schema_version":"1.0","event_id":"sha256:5f39b38a013e0cd1ce21144a75f7357982c56c261de512d9887a6ab2f6b6bbf5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/A2VT2I7PA2GGYYJRJQIOXEFNUP/bundle.json","state_url":"https://pith.science/pith/A2VT2I7PA2GGYYJRJQIOXEFNUP/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/A2VT2I7PA2GGYYJRJQIOXEFNUP/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-24T15:41:06Z","links":{"resolver":"https://pith.science/pith/A2VT2I7PA2GGYYJRJQIOXEFNUP","bundle":"https://pith.science/pith/A2VT2I7PA2GGYYJRJQIOXEFNUP/bundle.json","state":"https://pith.science/pith/A2VT2I7PA2GGYYJRJQIOXEFNUP/state.json","well_known_bundle":"https://pith.science/.well-known/pith/A2VT2I7PA2GGYYJRJQIOXEFNUP/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:A2VT2I7PA2GGYYJRJQIOXEFNUP","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7583ea3f92e380c2f405c306dc5923e5ea9cba39a9d88e5f70d4de9ab21253d0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:30:10Z","title_canon_sha256":"768642d98e86f11baff6b7817b0764c20f5dd76d9d1107eeb58c561f1ae2f2f1"},"schema_version":"1.0","source":{"id":"1812.04525","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.04525","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"arxiv_version","alias_value":"1812.04525v1","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.04525","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"pith_short_12","alias_value":"A2VT2I7PA2GG","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_16","alias_value":"A2VT2I7PA2GGYYJR","created_at":"2026-05-18T12:32:13Z"},{"alias_kind":"pith_short_8","alias_value":"A2VT2I7P","created_at":"2026-05-18T12:32:13Z"}],"graph_snapshots":[{"event_id":"sha256:5f39b38a013e0cd1ce21144a75f7357982c56c261de512d9887a6ab2f6b6bbf5","target":"graph","created_at":"2026-05-17T23:58:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of determining the parameter values from the output. In fact, structural identifiability becomes a particular case of observability if the parameters are considered as constant state variables. It is possible to simultaneously analyse the observability and structural identifiability of a model using the conceptual tools of differential geometry. Many complex biologi","authors_text":"Alejandro F. Villaverde","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:30:10Z","title":"Observability and Structural Identifiability of Nonlinear Biological Systems"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.04525","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:44ed908f1fd620a3f71b5a4a850615d512d23bee5c2dffc52e5156702a8aa024","target":"record","created_at":"2026-05-17T23:58:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7583ea3f92e380c2f405c306dc5923e5ea9cba39a9d88e5f70d4de9ab21253d0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:30:10Z","title_canon_sha256":"768642d98e86f11baff6b7817b0764c20f5dd76d9d1107eeb58c561f1ae2f2f1"},"schema_version":"1.0","source":{"id":"1812.04525","kind":"arxiv","version":1}},"canonical_sha256":"06ab3d23ef068c6c61314c10eb90ada3d9c100337f861157922daca549e51dc7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"06ab3d23ef068c6c61314c10eb90ada3d9c100337f861157922daca549e51dc7","first_computed_at":"2026-05-17T23:58:31.787695Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:58:31.787695Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"eKiHqJn1COlrSb/1fLQvt8VC9xiSZqca4bP1o5+jOyp+tw7r1Jm9fyZSDJyOiTwXEAIotHpRSZE7j8Rs5q1GCw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:58:31.788340Z","signed_message":"canonical_sha256_bytes"},"source_id":"1812.04525","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:44ed908f1fd620a3f71b5a4a850615d512d23bee5c2dffc52e5156702a8aa024","sha256:5f39b38a013e0cd1ce21144a75f7357982c56c261de512d9887a6ab2f6b6bbf5"],"state_sha256":"bd1bf991aa4e6ab19c9964de81aa2b75c473275b54b8c6e1e92d7b94ed34b5a9"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/NuzfMJ4nyIHiOeAo7v8vPaUQ0/gmNBzhFM7sMfzOERjLTgLy16w6xc+cTlxn7td4M5wixYH7vZ4zoKSEMndDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-24T15:41:06.270037Z","bundle_sha256":"1a9f3712eacddce92d0f061b4e4aac667c0737fa2841461c3d8d06b49e070a84"}}