{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2026:AAM46UPXM5HSTTIZIC52Y6QBZK","short_pith_number":"pith:AAM46UPX","schema_version":"1.0","canonical_sha256":"0019cf51f7674f29cd1940bbac7a01cabab8a71de2fa820b1815c93929893a3f","source":{"kind":"arxiv","id":"2606.13386","version":1},"attestation_state":"computed","paper":{"title":"Mathematical Modeling of HDV RNA, HBV DNA, and HBsAg Dynamics during Lonafarnib-Based Therapy: Insights from the LOWR HDV-1 Study","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"physics.soc-ph","authors_text":"Adquate Mhlanga, Alexander Churkin, Ashish Goyal, Cihan Yurdaydin, Danny Barash, Harel Dahari, Jeffrey Glenn, Louis Shekhtman, Ohad Etzion, Rami Zakh, Sarah Duehren, Scott J. Cotler, Vladimir Reinharz","submitted_at":"2026-06-11T14:16:09Z","abstract_excerpt":"Lonafarnib (LNF) is an investigational drug targeting hepatitis delta virus (HDV) but not hepatitis B virus (HBV), providing a unique opportunity to model HDV kinetics and how changes in HDV affect HBV. We performed a detailed kinetic analysis and developed a mathematical model to explain serum HBV DNA, HDV RNA and hepatitis B surface antigen (HBsAg) kinetics in 15 HBV/HDV coinfected patients receiving LNF-based treatment. After a delay of 0-2 days, patients experienced a rapid 1st-phase HDV-decline followed by either a viral plateau, 2nd slower-decline phase, or viral breakthrough (VB). LNF m"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2606.13386","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2026-06-11T14:16:09Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"9dc66852b395895c6adaa0d138eec4bb1fcea15b84566ff2d7f0fbfd21d231a7","abstract_canon_sha256":"d3b969804c10412e6569af7abc7be718c84677e681d626d4e15f9ea60df9736a"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-12T01:09:59.213418Z","signature_b64":"5Hxi6xwZBHlsSxfFbwruZr0hTK8EZ2LBr61ruwqmTW8jNh8s7A5m3HAx82iHBPuP+JN/lWVlTyP291p28vv6Bw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0019cf51f7674f29cd1940bbac7a01cabab8a71de2fa820b1815c93929893a3f","last_reissued_at":"2026-06-12T01:09:59.212546Z","signature_status":"signed_v1","first_computed_at":"2026-06-12T01:09:59.212546Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Mathematical Modeling of HDV RNA, HBV DNA, and HBsAg Dynamics during Lonafarnib-Based Therapy: Insights from the LOWR HDV-1 Study","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"physics.soc-ph","authors_text":"Adquate Mhlanga, Alexander Churkin, Ashish Goyal, Cihan Yurdaydin, Danny Barash, Harel Dahari, Jeffrey Glenn, Louis Shekhtman, Ohad Etzion, Rami Zakh, Sarah Duehren, Scott J. Cotler, Vladimir Reinharz","submitted_at":"2026-06-11T14:16:09Z","abstract_excerpt":"Lonafarnib (LNF) is an investigational drug targeting hepatitis delta virus (HDV) but not hepatitis B virus (HBV), providing a unique opportunity to model HDV kinetics and how changes in HDV affect HBV. We performed a detailed kinetic analysis and developed a mathematical model to explain serum HBV DNA, HDV RNA and hepatitis B surface antigen (HBsAg) kinetics in 15 HBV/HDV coinfected patients receiving LNF-based treatment. After a delay of 0-2 days, patients experienced a rapid 1st-phase HDV-decline followed by either a viral plateau, 2nd slower-decline phase, or viral breakthrough (VB). LNF m"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.13386","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.13386/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2606.13386","created_at":"2026-06-12T01:09:59.212704+00:00"},{"alias_kind":"arxiv_version","alias_value":"2606.13386v1","created_at":"2026-06-12T01:09:59.212704+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.13386","created_at":"2026-06-12T01:09:59.212704+00:00"},{"alias_kind":"pith_short_12","alias_value":"AAM46UPXM5HS","created_at":"2026-06-12T01:09:59.212704+00:00"},{"alias_kind":"pith_short_16","alias_value":"AAM46UPXM5HSTTIZ","created_at":"2026-06-12T01:09:59.212704+00:00"},{"alias_kind":"pith_short_8","alias_value":"AAM46UPX","created_at":"2026-06-12T01:09:59.212704+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK","json":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK.json","graph_json":"https://pith.science/api/pith-number/AAM46UPXM5HSTTIZIC52Y6QBZK/graph.json","events_json":"https://pith.science/api/pith-number/AAM46UPXM5HSTTIZIC52Y6QBZK/events.json","paper":"https://pith.science/paper/AAM46UPX"},"agent_actions":{"view_html":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK","download_json":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK.json","view_paper":"https://pith.science/paper/AAM46UPX","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2606.13386&json=true","fetch_graph":"https://pith.science/api/pith-number/AAM46UPXM5HSTTIZIC52Y6QBZK/graph.json","fetch_events":"https://pith.science/api/pith-number/AAM46UPXM5HSTTIZIC52Y6QBZK/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/action/timestamp_anchor","attest_storage":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/action/storage_attestation","attest_author":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/action/author_attestation","sign_citation":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/action/citation_signature","submit_replication":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/action/replication_record"}},"created_at":"2026-06-12T01:09:59.212704+00:00","updated_at":"2026-06-12T01:09:59.212704+00:00"}