{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:AAM46UPXM5HSTTIZIC52Y6QBZK","short_pith_number":"pith:AAM46UPX","canonical_record":{"source":{"id":"2606.13386","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2026-06-11T14:16:09Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"9dc66852b395895c6adaa0d138eec4bb1fcea15b84566ff2d7f0fbfd21d231a7","abstract_canon_sha256":"d3b969804c10412e6569af7abc7be718c84677e681d626d4e15f9ea60df9736a"},"schema_version":"1.0"},"canonical_sha256":"0019cf51f7674f29cd1940bbac7a01cabab8a71de2fa820b1815c93929893a3f","source":{"kind":"arxiv","id":"2606.13386","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.13386","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"arxiv_version","alias_value":"2606.13386v1","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.13386","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"pith_short_12","alias_value":"AAM46UPXM5HS","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"pith_short_16","alias_value":"AAM46UPXM5HSTTIZ","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"pith_short_8","alias_value":"AAM46UPX","created_at":"2026-06-12T01:09:59Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:AAM46UPXM5HSTTIZIC52Y6QBZK","target":"record","payload":{"canonical_record":{"source":{"id":"2606.13386","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2026-06-11T14:16:09Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"9dc66852b395895c6adaa0d138eec4bb1fcea15b84566ff2d7f0fbfd21d231a7","abstract_canon_sha256":"d3b969804c10412e6569af7abc7be718c84677e681d626d4e15f9ea60df9736a"},"schema_version":"1.0"},"canonical_sha256":"0019cf51f7674f29cd1940bbac7a01cabab8a71de2fa820b1815c93929893a3f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-12T01:09:59.213418Z","signature_b64":"5Hxi6xwZBHlsSxfFbwruZr0hTK8EZ2LBr61ruwqmTW8jNh8s7A5m3HAx82iHBPuP+JN/lWVlTyP291p28vv6Bw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0019cf51f7674f29cd1940bbac7a01cabab8a71de2fa820b1815c93929893a3f","last_reissued_at":"2026-06-12T01:09:59.212546Z","signature_status":"signed_v1","first_computed_at":"2026-06-12T01:09:59.212546Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2606.13386","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-12T01:09:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"z+cxUs7AqDD/OlHlFqz9z92NN4ae8gkaRCbZhXoG7cCNvbWJ7ilhRdslGHB8esi6sUzuEyiYUoVNGSTpJZmqAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-30T04:00:11.944937Z"},"content_sha256":"079bb20c6b34cbc7e1c3ddc5b5056a4b805916d963cc910eed3d89f2430b38f4","schema_version":"1.0","event_id":"sha256:079bb20c6b34cbc7e1c3ddc5b5056a4b805916d963cc910eed3d89f2430b38f4"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:AAM46UPXM5HSTTIZIC52Y6QBZK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Mathematical Modeling of HDV RNA, HBV DNA, and HBsAg Dynamics during Lonafarnib-Based Therapy: Insights from the LOWR HDV-1 Study","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"physics.soc-ph","authors_text":"Adquate Mhlanga, Alexander Churkin, Ashish Goyal, Cihan Yurdaydin, Danny Barash, Harel Dahari, Jeffrey Glenn, Louis Shekhtman, Ohad Etzion, Rami Zakh, Sarah Duehren, Scott J. Cotler, Vladimir Reinharz","submitted_at":"2026-06-11T14:16:09Z","abstract_excerpt":"Lonafarnib (LNF) is an investigational drug targeting hepatitis delta virus (HDV) but not hepatitis B virus (HBV), providing a unique opportunity to model HDV kinetics and how changes in HDV affect HBV. We performed a detailed kinetic analysis and developed a mathematical model to explain serum HBV DNA, HDV RNA and hepatitis B surface antigen (HBsAg) kinetics in 15 HBV/HDV coinfected patients receiving LNF-based treatment. After a delay of 0-2 days, patients experienced a rapid 1st-phase HDV-decline followed by either a viral plateau, 2nd slower-decline phase, or viral breakthrough (VB). LNF m"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.13386","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.13386/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-12T01:09:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Q1Kd5BkPhgLFf+3H/MqhTRl++9KBrHqJvPjGqby1ahjSdeBQKUu0bH/LZQKg5OSNgn0710Cq3keXOkycXddIDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-30T04:00:11.945356Z"},"content_sha256":"c51350c196ca2033c78e061deb079e0624ceca872a4d607222ce9235e1587581","schema_version":"1.0","event_id":"sha256:c51350c196ca2033c78e061deb079e0624ceca872a4d607222ce9235e1587581"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/bundle.json","state_url":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-30T04:00:11Z","links":{"resolver":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK","bundle":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/bundle.json","state":"https://pith.science/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/AAM46UPXM5HSTTIZIC52Y6QBZK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:AAM46UPXM5HSTTIZIC52Y6QBZK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d3b969804c10412e6569af7abc7be718c84677e681d626d4e15f9ea60df9736a","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2026-06-11T14:16:09Z","title_canon_sha256":"9dc66852b395895c6adaa0d138eec4bb1fcea15b84566ff2d7f0fbfd21d231a7"},"schema_version":"1.0","source":{"id":"2606.13386","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.13386","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"arxiv_version","alias_value":"2606.13386v1","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.13386","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"pith_short_12","alias_value":"AAM46UPXM5HS","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"pith_short_16","alias_value":"AAM46UPXM5HSTTIZ","created_at":"2026-06-12T01:09:59Z"},{"alias_kind":"pith_short_8","alias_value":"AAM46UPX","created_at":"2026-06-12T01:09:59Z"}],"graph_snapshots":[{"event_id":"sha256:c51350c196ca2033c78e061deb079e0624ceca872a4d607222ce9235e1587581","target":"graph","created_at":"2026-06-12T01:09:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.13386/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Lonafarnib (LNF) is an investigational drug targeting hepatitis delta virus (HDV) but not hepatitis B virus (HBV), providing a unique opportunity to model HDV kinetics and how changes in HDV affect HBV. We performed a detailed kinetic analysis and developed a mathematical model to explain serum HBV DNA, HDV RNA and hepatitis B surface antigen (HBsAg) kinetics in 15 HBV/HDV coinfected patients receiving LNF-based treatment. After a delay of 0-2 days, patients experienced a rapid 1st-phase HDV-decline followed by either a viral plateau, 2nd slower-decline phase, or viral breakthrough (VB). LNF m","authors_text":"Adquate Mhlanga, Alexander Churkin, Ashish Goyal, Cihan Yurdaydin, Danny Barash, Harel Dahari, Jeffrey Glenn, Louis Shekhtman, Ohad Etzion, Rami Zakh, Sarah Duehren, Scott J. Cotler, Vladimir Reinharz","cross_cats":["q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2026-06-11T14:16:09Z","title":"Mathematical Modeling of HDV RNA, HBV DNA, and HBsAg Dynamics during Lonafarnib-Based Therapy: Insights from the LOWR HDV-1 Study"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.13386","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:079bb20c6b34cbc7e1c3ddc5b5056a4b805916d963cc910eed3d89f2430b38f4","target":"record","created_at":"2026-06-12T01:09:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d3b969804c10412e6569af7abc7be718c84677e681d626d4e15f9ea60df9736a","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2026-06-11T14:16:09Z","title_canon_sha256":"9dc66852b395895c6adaa0d138eec4bb1fcea15b84566ff2d7f0fbfd21d231a7"},"schema_version":"1.0","source":{"id":"2606.13386","kind":"arxiv","version":1}},"canonical_sha256":"0019cf51f7674f29cd1940bbac7a01cabab8a71de2fa820b1815c93929893a3f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0019cf51f7674f29cd1940bbac7a01cabab8a71de2fa820b1815c93929893a3f","first_computed_at":"2026-06-12T01:09:59.212546Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-12T01:09:59.212546Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"5Hxi6xwZBHlsSxfFbwruZr0hTK8EZ2LBr61ruwqmTW8jNh8s7A5m3HAx82iHBPuP+JN/lWVlTyP291p28vv6Bw==","signature_status":"signed_v1","signed_at":"2026-06-12T01:09:59.213418Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.13386","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:079bb20c6b34cbc7e1c3ddc5b5056a4b805916d963cc910eed3d89f2430b38f4","sha256:c51350c196ca2033c78e061deb079e0624ceca872a4d607222ce9235e1587581"],"state_sha256":"f76b5b80ddbe657d60e16730ceb760db3633a55cd3f6359d495265ce450be2dd"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gikKK+GYMS4/Nqa7gg8P9Fg36gV+5I25cEwpwB7YB5Bix1xmVlK/rstdbrOofAlC9WUiewYcN8DfoktF8qmRCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-30T04:00:11.948026Z","bundle_sha256":"d9d7cec84e0d0229c94947a8a006014c7db8194e13a35117c655abbf2e2ea51e"}}