{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:ADIIRLMP7JWCC2PSOXIIKJL4TK","short_pith_number":"pith:ADIIRLMP","canonical_record":{"source":{"id":"1204.0710","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-03T15:26:53Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"65364bba201c679e5dfdb000ba68672bce2ac5f29bc9aec6e08480f0e369af34","abstract_canon_sha256":"899e6271e4db3cca6dff632b5bda7cf35ae81cbd1a365d1665e433d7d07b316d"},"schema_version":"1.0"},"canonical_sha256":"00d088ad8ffa6c2169f275d085257c9ab9acf6f3af8f0c42d6f1308ac826bcd3","source":{"kind":"arxiv","id":"1204.0710","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1204.0710","created_at":"2026-05-18T03:58:38Z"},{"alias_kind":"arxiv_version","alias_value":"1204.0710v1","created_at":"2026-05-18T03:58:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1204.0710","created_at":"2026-05-18T03:58:38Z"},{"alias_kind":"pith_short_12","alias_value":"ADIIRLMP7JWC","created_at":"2026-05-18T12:26:58Z"},{"alias_kind":"pith_short_16","alias_value":"ADIIRLMP7JWCC2PS","created_at":"2026-05-18T12:26:58Z"},{"alias_kind":"pith_short_8","alias_value":"ADIIRLMP","created_at":"2026-05-18T12:26:58Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:ADIIRLMP7JWCC2PSOXIIKJL4TK","target":"record","payload":{"canonical_record":{"source":{"id":"1204.0710","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-03T15:26:53Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"65364bba201c679e5dfdb000ba68672bce2ac5f29bc9aec6e08480f0e369af34","abstract_canon_sha256":"899e6271e4db3cca6dff632b5bda7cf35ae81cbd1a365d1665e433d7d07b316d"},"schema_version":"1.0"},"canonical_sha256":"00d088ad8ffa6c2169f275d085257c9ab9acf6f3af8f0c42d6f1308ac826bcd3","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:58:38.675594Z","signature_b64":"oLZdgrXwgIqbxVlibz6qgSon6Xh/ApTZVWPyttdjvlDwZiBZpb4/kWGyc4j7uHAzlrEDTfvIoaKGihI5aJF/Cg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"00d088ad8ffa6c2169f275d085257c9ab9acf6f3af8f0c42d6f1308ac826bcd3","last_reissued_at":"2026-05-18T03:58:38.675123Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:58:38.675123Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1204.0710","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:58:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YFTOTtiWDMg9llsEQAojBgPrP04VaqLe9kheq92josaTbeKV+7EZf1fTkxIiISP83SRnthJ46YAEohuJPbV4Dw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-28T12:14:27.732421Z"},"content_sha256":"1d5a50d32d3c1db1d6095e719ffb758e5e26e26144d11373634da42b31f4c293","schema_version":"1.0","event_id":"sha256:1d5a50d32d3c1db1d6095e719ffb758e5e26e26144d11373634da42b31f4c293"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:ADIIRLMP7JWCC2PSOXIIKJL4TK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex","license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"q-bio.NC","authors_text":"Donald C. Cooper, Matthew B. Pomrenze, Michael V. Baratta, Peter Dobelis, Samuel D. Dolzani, Shinya Nakamura","submitted_at":"2012-04-03T15:26:53Z","abstract_excerpt":"A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information among prefrontal neuronal subtypes is the inability to manipulate the electrical activity of genetically defined cell types over behaviorally relevant timescales and activity patterns. To address these constraints, we present here a simple approach for selective activation of prefrontal excitatory neurons in both in vitro and in vivo preparations. Rat prelimbi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1204.0710","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:58:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mg21hX3kHbCKxZtTxa4qdXP2M7MgRpAg4dMB+9EhN3OivpE5YTGBSNL/4KBVhVC3W3r/puaUVawxi8oPoSArDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-28T12:14:27.732780Z"},"content_sha256":"13e15950134f74cd551d66561d2159dd930f3bd90e83965b633e35d285e499a8","schema_version":"1.0","event_id":"sha256:13e15950134f74cd551d66561d2159dd930f3bd90e83965b633e35d285e499a8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ADIIRLMP7JWCC2PSOXIIKJL4TK/bundle.json","state_url":"https://pith.science/pith/ADIIRLMP7JWCC2PSOXIIKJL4TK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ADIIRLMP7JWCC2PSOXIIKJL4TK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-28T12:14:27Z","links":{"resolver":"https://pith.science/pith/ADIIRLMP7JWCC2PSOXIIKJL4TK","bundle":"https://pith.science/pith/ADIIRLMP7JWCC2PSOXIIKJL4TK/bundle.json","state":"https://pith.science/pith/ADIIRLMP7JWCC2PSOXIIKJL4TK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ADIIRLMP7JWCC2PSOXIIKJL4TK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:ADIIRLMP7JWCC2PSOXIIKJL4TK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"899e6271e4db3cca6dff632b5bda7cf35ae81cbd1a365d1665e433d7d07b316d","cross_cats_sorted":["q-bio.CB"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-03T15:26:53Z","title_canon_sha256":"65364bba201c679e5dfdb000ba68672bce2ac5f29bc9aec6e08480f0e369af34"},"schema_version":"1.0","source":{"id":"1204.0710","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1204.0710","created_at":"2026-05-18T03:58:38Z"},{"alias_kind":"arxiv_version","alias_value":"1204.0710v1","created_at":"2026-05-18T03:58:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1204.0710","created_at":"2026-05-18T03:58:38Z"},{"alias_kind":"pith_short_12","alias_value":"ADIIRLMP7JWC","created_at":"2026-05-18T12:26:58Z"},{"alias_kind":"pith_short_16","alias_value":"ADIIRLMP7JWCC2PS","created_at":"2026-05-18T12:26:58Z"},{"alias_kind":"pith_short_8","alias_value":"ADIIRLMP","created_at":"2026-05-18T12:26:58Z"}],"graph_snapshots":[{"event_id":"sha256:13e15950134f74cd551d66561d2159dd930f3bd90e83965b633e35d285e499a8","target":"graph","created_at":"2026-05-18T03:58:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information among prefrontal neuronal subtypes is the inability to manipulate the electrical activity of genetically defined cell types over behaviorally relevant timescales and activity patterns. To address these constraints, we present here a simple approach for selective activation of prefrontal excitatory neurons in both in vitro and in vivo preparations. Rat prelimbi","authors_text":"Donald C. Cooper, Matthew B. Pomrenze, Michael V. Baratta, Peter Dobelis, Samuel D. Dolzani, Shinya Nakamura","cross_cats":["q-bio.CB"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-03T15:26:53Z","title":"Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1204.0710","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1d5a50d32d3c1db1d6095e719ffb758e5e26e26144d11373634da42b31f4c293","target":"record","created_at":"2026-05-18T03:58:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"899e6271e4db3cca6dff632b5bda7cf35ae81cbd1a365d1665e433d7d07b316d","cross_cats_sorted":["q-bio.CB"],"license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","primary_cat":"q-bio.NC","submitted_at":"2012-04-03T15:26:53Z","title_canon_sha256":"65364bba201c679e5dfdb000ba68672bce2ac5f29bc9aec6e08480f0e369af34"},"schema_version":"1.0","source":{"id":"1204.0710","kind":"arxiv","version":1}},"canonical_sha256":"00d088ad8ffa6c2169f275d085257c9ab9acf6f3af8f0c42d6f1308ac826bcd3","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"00d088ad8ffa6c2169f275d085257c9ab9acf6f3af8f0c42d6f1308ac826bcd3","first_computed_at":"2026-05-18T03:58:38.675123Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:58:38.675123Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oLZdgrXwgIqbxVlibz6qgSon6Xh/ApTZVWPyttdjvlDwZiBZpb4/kWGyc4j7uHAzlrEDTfvIoaKGihI5aJF/Cg==","signature_status":"signed_v1","signed_at":"2026-05-18T03:58:38.675594Z","signed_message":"canonical_sha256_bytes"},"source_id":"1204.0710","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1d5a50d32d3c1db1d6095e719ffb758e5e26e26144d11373634da42b31f4c293","sha256:13e15950134f74cd551d66561d2159dd930f3bd90e83965b633e35d285e499a8"],"state_sha256":"d5ca1e83c04a0b18d6650ce548537a02e5df13ccc6474703eb0cdc71b1ec7ad9"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"XkXioS72A/TqN+J/zPWIobIlKohRqCN9q4tupbUePBXWuFYquAetj+Eu85AlsMt8bTTvWtOtlXlfGvoQ5slBAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-28T12:14:27.734961Z","bundle_sha256":"fc3c7f6c7851de896c159a2682bba01072ba02ab6767b6906c003b3f441fc9d8"}}