{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:AQ5JG26W5VGBBRQCQU3DS4KQ2Y","short_pith_number":"pith:AQ5JG26W","canonical_record":{"source":{"id":"2607.00500","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-07-01T06:32:10Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"f71a63920366b25f0bd26fe6ff660b45081d0f7f635e2ae478c2659dc58f76ab","abstract_canon_sha256":"9de63b6ca68905c34b9719b64e2bb3fc1a327153961aa3d0a115c06319e2f03a"},"schema_version":"1.0"},"canonical_sha256":"043a936bd6ed4c10c6028536397150d626a9c2524b2880069081cf83a8bdecfd","source":{"kind":"arxiv","id":"2607.00500","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.00500","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"arxiv_version","alias_value":"2607.00500v1","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.00500","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"pith_short_12","alias_value":"AQ5JG26W5VGB","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"pith_short_16","alias_value":"AQ5JG26W5VGBBRQC","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"pith_short_8","alias_value":"AQ5JG26W","created_at":"2026-07-02T01:17:45Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:AQ5JG26W5VGBBRQCQU3DS4KQ2Y","target":"record","payload":{"canonical_record":{"source":{"id":"2607.00500","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-07-01T06:32:10Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"f71a63920366b25f0bd26fe6ff660b45081d0f7f635e2ae478c2659dc58f76ab","abstract_canon_sha256":"9de63b6ca68905c34b9719b64e2bb3fc1a327153961aa3d0a115c06319e2f03a"},"schema_version":"1.0"},"canonical_sha256":"043a936bd6ed4c10c6028536397150d626a9c2524b2880069081cf83a8bdecfd","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-02T01:17:45.221057Z","signature_b64":"EKlViqYv3Z/j0vl/cfuucLh03m2NJtVkFSIZ7GcNH3W9qNa2eZnCFoYbhXSXchyXtGj/sjxoAc4Vlsr9aNLpAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"043a936bd6ed4c10c6028536397150d626a9c2524b2880069081cf83a8bdecfd","last_reissued_at":"2026-07-02T01:17:45.220645Z","signature_status":"signed_v1","first_computed_at":"2026-07-02T01:17:45.220645Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2607.00500","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-02T01:17:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vrl8owJbGiuGmhgM9eBjyNBVYTeChenLyGDYtG55UBv73AnqJ4f+IenZTSaxbuZWlfMJwmEgcWfG4D2nRDxlBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T21:31:32.108006Z"},"content_sha256":"2ec8e9391572734620677aca29fe3a2df98322eaf03b013753eea70076a6b1ab","schema_version":"1.0","event_id":"sha256:2ec8e9391572734620677aca29fe3a2df98322eaf03b013753eea70076a6b1ab"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:AQ5JG26W5VGBBRQCQU3DS4KQ2Y","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Closed-loop coupling of personalised and foundation models for real-time treatment guidance with MRI","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.CV"],"primary_cat":"physics.med-ph","authors_text":"Andrew Phair, David E.J. Waddington, Emily A. Hewson, Hilary L. Byrne, James Grover, Michael Ferraro, Michael G. Jameson, Paul Keall","submitted_at":"2026-07-01T06:32:10Z","abstract_excerpt":"Image-guided therapies, including radiotherapy, biopsy and deep brain stimulation, rely on real-time targeting of anatomical structures. However, in the presence of motion, imaging latencies create a temporal misalignment between observed and true anatomy, compromising treatment accuracy. Artificial intelligence-based frameworks have increasingly been presented to close this latency gap, but leading personalised models can fail due to a lack of stable anatomical grounding. Foundation models can provide grounded behaviour, but they do not adapt to real-time, individual patient dynamics. Here we"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.00500","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.00500/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-02T01:17:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3eM5D8Bw3iRgwUtZapBKBJ0RVpTvx8/smywMkie81i05H0Sdxu2M4kqpcupAP/m7i9YjQnmEXekgkzxezpEVDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T21:31:32.108392Z"},"content_sha256":"8d97d79a4ca25f37cfa054f4523401df311a430c93b37708bdd013ed1af952f6","schema_version":"1.0","event_id":"sha256:8d97d79a4ca25f37cfa054f4523401df311a430c93b37708bdd013ed1af952f6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/AQ5JG26W5VGBBRQCQU3DS4KQ2Y/bundle.json","state_url":"https://pith.science/pith/AQ5JG26W5VGBBRQCQU3DS4KQ2Y/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/AQ5JG26W5VGBBRQCQU3DS4KQ2Y/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-03T21:31:32Z","links":{"resolver":"https://pith.science/pith/AQ5JG26W5VGBBRQCQU3DS4KQ2Y","bundle":"https://pith.science/pith/AQ5JG26W5VGBBRQCQU3DS4KQ2Y/bundle.json","state":"https://pith.science/pith/AQ5JG26W5VGBBRQCQU3DS4KQ2Y/state.json","well_known_bundle":"https://pith.science/.well-known/pith/AQ5JG26W5VGBBRQCQU3DS4KQ2Y/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:AQ5JG26W5VGBBRQCQU3DS4KQ2Y","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9de63b6ca68905c34b9719b64e2bb3fc1a327153961aa3d0a115c06319e2f03a","cross_cats_sorted":["cs.CV"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-07-01T06:32:10Z","title_canon_sha256":"f71a63920366b25f0bd26fe6ff660b45081d0f7f635e2ae478c2659dc58f76ab"},"schema_version":"1.0","source":{"id":"2607.00500","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.00500","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"arxiv_version","alias_value":"2607.00500v1","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.00500","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"pith_short_12","alias_value":"AQ5JG26W5VGB","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"pith_short_16","alias_value":"AQ5JG26W5VGBBRQC","created_at":"2026-07-02T01:17:45Z"},{"alias_kind":"pith_short_8","alias_value":"AQ5JG26W","created_at":"2026-07-02T01:17:45Z"}],"graph_snapshots":[{"event_id":"sha256:8d97d79a4ca25f37cfa054f4523401df311a430c93b37708bdd013ed1af952f6","target":"graph","created_at":"2026-07-02T01:17:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2607.00500/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Image-guided therapies, including radiotherapy, biopsy and deep brain stimulation, rely on real-time targeting of anatomical structures. However, in the presence of motion, imaging latencies create a temporal misalignment between observed and true anatomy, compromising treatment accuracy. Artificial intelligence-based frameworks have increasingly been presented to close this latency gap, but leading personalised models can fail due to a lack of stable anatomical grounding. Foundation models can provide grounded behaviour, but they do not adapt to real-time, individual patient dynamics. Here we","authors_text":"Andrew Phair, David E.J. Waddington, Emily A. Hewson, Hilary L. Byrne, James Grover, Michael Ferraro, Michael G. Jameson, Paul Keall","cross_cats":["cs.CV"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-07-01T06:32:10Z","title":"Closed-loop coupling of personalised and foundation models for real-time treatment guidance with MRI"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.00500","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2ec8e9391572734620677aca29fe3a2df98322eaf03b013753eea70076a6b1ab","target":"record","created_at":"2026-07-02T01:17:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9de63b6ca68905c34b9719b64e2bb3fc1a327153961aa3d0a115c06319e2f03a","cross_cats_sorted":["cs.CV"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-07-01T06:32:10Z","title_canon_sha256":"f71a63920366b25f0bd26fe6ff660b45081d0f7f635e2ae478c2659dc58f76ab"},"schema_version":"1.0","source":{"id":"2607.00500","kind":"arxiv","version":1}},"canonical_sha256":"043a936bd6ed4c10c6028536397150d626a9c2524b2880069081cf83a8bdecfd","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"043a936bd6ed4c10c6028536397150d626a9c2524b2880069081cf83a8bdecfd","first_computed_at":"2026-07-02T01:17:45.220645Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-02T01:17:45.220645Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"EKlViqYv3Z/j0vl/cfuucLh03m2NJtVkFSIZ7GcNH3W9qNa2eZnCFoYbhXSXchyXtGj/sjxoAc4Vlsr9aNLpAw==","signature_status":"signed_v1","signed_at":"2026-07-02T01:17:45.221057Z","signed_message":"canonical_sha256_bytes"},"source_id":"2607.00500","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2ec8e9391572734620677aca29fe3a2df98322eaf03b013753eea70076a6b1ab","sha256:8d97d79a4ca25f37cfa054f4523401df311a430c93b37708bdd013ed1af952f6"],"state_sha256":"c2c3eb22072475d0c47436ce3bbe0e890bbd216c4f76039948facdf6fbec2a3b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"y2OEFFSy9Vf+wb/Gqlb8oi02mh93Te69EjOtHtmntmoKSJNJdHw+Cioi51zf8Uoisl+fREJ7eDDjHSAJ0i9MCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-03T21:31:32.110338Z","bundle_sha256":"71489604a19e47bc3e068c34f78f1449b8b81b0d8672e52aa45aeede0226f585"}}