{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:AWA43677ZDU4HG2534XN7LEVYR","short_pith_number":"pith:AWA43677","canonical_record":{"source":{"id":"2606.29949","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-29T08:24:53Z","cross_cats_sorted":["cs.AI","q-bio.GN"],"title_canon_sha256":"33814c9f9cd4de353bf5caff549e041b423e8918316657cd80cce13f60e667d5","abstract_canon_sha256":"73682608758b203783baef7da92556cf4dc428f59898c0142d94215b96371a43"},"schema_version":"1.0"},"canonical_sha256":"0581cdfbffc8e9c39b5ddf2edfac95c4542d1a1bf2c89783c0dd8efa6d6a7bec","source":{"kind":"arxiv","id":"2606.29949","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.29949","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"arxiv_version","alias_value":"2606.29949v1","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.29949","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"pith_short_12","alias_value":"AWA43677ZDU4","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"pith_short_16","alias_value":"AWA43677ZDU4HG25","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"pith_short_8","alias_value":"AWA43677","created_at":"2026-06-30T02:17:42Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:AWA43677ZDU4HG2534XN7LEVYR","target":"record","payload":{"canonical_record":{"source":{"id":"2606.29949","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-29T08:24:53Z","cross_cats_sorted":["cs.AI","q-bio.GN"],"title_canon_sha256":"33814c9f9cd4de353bf5caff549e041b423e8918316657cd80cce13f60e667d5","abstract_canon_sha256":"73682608758b203783baef7da92556cf4dc428f59898c0142d94215b96371a43"},"schema_version":"1.0"},"canonical_sha256":"0581cdfbffc8e9c39b5ddf2edfac95c4542d1a1bf2c89783c0dd8efa6d6a7bec","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-30T02:17:42.334239Z","signature_b64":"W1mLCSze7rQETEa9P9a2l1DbDldp0wr6V0SBjykcxCHkuVH8gy4knBRX0qM3q+wxuPI8ISdrGrM9EXKigGBNBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0581cdfbffc8e9c39b5ddf2edfac95c4542d1a1bf2c89783c0dd8efa6d6a7bec","last_reissued_at":"2026-06-30T02:17:42.333566Z","signature_status":"signed_v1","first_computed_at":"2026-06-30T02:17:42.333566Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2606.29949","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-30T02:17:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KbRK3eJA+SZ8qBR6DTvBDc6V+p74+FXdmD9VzPjVTosxW9HuFtajQJDq8xHn/F7crMHWxEgGc6voR5MFaQLSDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-04T17:16:24.211351Z"},"content_sha256":"df2977ef24b79085581f33cc156b04b54a04b14e32fba59058ccb34333a5f2fb","schema_version":"1.0","event_id":"sha256:df2977ef24b79085581f33cc156b04b54a04b14e32fba59058ccb34333a5f2fb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:AWA43677ZDU4HG2534XN7LEVYR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Data-Efficient Multimodal Alignment for Histopathology-based Molecular Prediction","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cs.AI","q-bio.GN"],"primary_cat":"eess.IV","authors_text":"Christian Gebbe, Dominik Vonficht, Dominik Winter, Lo\\\"ic Le Bescond, Marco Rosati, Markus Schick, Nicolas Brieu, Richard J. Chen, Ross Stewart","submitted_at":"2026-06-29T08:24:53Z","abstract_excerpt":"H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability. We show that training a lightweight alignment module atop frozen histopathology and RNA-Seq foundation models enables open-vocabulary molecular prompting -- querying H&E slides with gene-set signatures to predict pathway activity without sequencing or end-to-end retraining. Using contrastive learning on a multi-cancer cohort (N=1,720), we achieve a 25-fold improvement "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.29949","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.29949/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-30T02:17:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9AOwAuP795VabSZkVlRzfAwnAcdN3CJoMbaibU+2WvG8LoF4ptSrB9CXsDDH1olM5cQh1JCSj14nux76uddtCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-04T17:16:24.211786Z"},"content_sha256":"ca9ee683e06264ffbede1a435a17acfdb0ea55f27640b609c3459846bc084625","schema_version":"1.0","event_id":"sha256:ca9ee683e06264ffbede1a435a17acfdb0ea55f27640b609c3459846bc084625"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/AWA43677ZDU4HG2534XN7LEVYR/bundle.json","state_url":"https://pith.science/pith/AWA43677ZDU4HG2534XN7LEVYR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/AWA43677ZDU4HG2534XN7LEVYR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-04T17:16:24Z","links":{"resolver":"https://pith.science/pith/AWA43677ZDU4HG2534XN7LEVYR","bundle":"https://pith.science/pith/AWA43677ZDU4HG2534XN7LEVYR/bundle.json","state":"https://pith.science/pith/AWA43677ZDU4HG2534XN7LEVYR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/AWA43677ZDU4HG2534XN7LEVYR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:AWA43677ZDU4HG2534XN7LEVYR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"73682608758b203783baef7da92556cf4dc428f59898c0142d94215b96371a43","cross_cats_sorted":["cs.AI","q-bio.GN"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-29T08:24:53Z","title_canon_sha256":"33814c9f9cd4de353bf5caff549e041b423e8918316657cd80cce13f60e667d5"},"schema_version":"1.0","source":{"id":"2606.29949","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.29949","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"arxiv_version","alias_value":"2606.29949v1","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.29949","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"pith_short_12","alias_value":"AWA43677ZDU4","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"pith_short_16","alias_value":"AWA43677ZDU4HG25","created_at":"2026-06-30T02:17:42Z"},{"alias_kind":"pith_short_8","alias_value":"AWA43677","created_at":"2026-06-30T02:17:42Z"}],"graph_snapshots":[{"event_id":"sha256:ca9ee683e06264ffbede1a435a17acfdb0ea55f27640b609c3459846bc084625","target":"graph","created_at":"2026-06-30T02:17:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.29949/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability. We show that training a lightweight alignment module atop frozen histopathology and RNA-Seq foundation models enables open-vocabulary molecular prompting -- querying H&E slides with gene-set signatures to predict pathway activity without sequencing or end-to-end retraining. Using contrastive learning on a multi-cancer cohort (N=1,720), we achieve a 25-fold improvement ","authors_text":"Christian Gebbe, Dominik Vonficht, Dominik Winter, Lo\\\"ic Le Bescond, Marco Rosati, Markus Schick, Nicolas Brieu, Richard J. Chen, Ross Stewart","cross_cats":["cs.AI","q-bio.GN"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-29T08:24:53Z","title":"Data-Efficient Multimodal Alignment for Histopathology-based Molecular Prediction"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.29949","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:df2977ef24b79085581f33cc156b04b54a04b14e32fba59058ccb34333a5f2fb","target":"record","created_at":"2026-06-30T02:17:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"73682608758b203783baef7da92556cf4dc428f59898c0142d94215b96371a43","cross_cats_sorted":["cs.AI","q-bio.GN"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-29T08:24:53Z","title_canon_sha256":"33814c9f9cd4de353bf5caff549e041b423e8918316657cd80cce13f60e667d5"},"schema_version":"1.0","source":{"id":"2606.29949","kind":"arxiv","version":1}},"canonical_sha256":"0581cdfbffc8e9c39b5ddf2edfac95c4542d1a1bf2c89783c0dd8efa6d6a7bec","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0581cdfbffc8e9c39b5ddf2edfac95c4542d1a1bf2c89783c0dd8efa6d6a7bec","first_computed_at":"2026-06-30T02:17:42.333566Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-30T02:17:42.333566Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"W1mLCSze7rQETEa9P9a2l1DbDldp0wr6V0SBjykcxCHkuVH8gy4knBRX0qM3q+wxuPI8ISdrGrM9EXKigGBNBw==","signature_status":"signed_v1","signed_at":"2026-06-30T02:17:42.334239Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.29949","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:df2977ef24b79085581f33cc156b04b54a04b14e32fba59058ccb34333a5f2fb","sha256:ca9ee683e06264ffbede1a435a17acfdb0ea55f27640b609c3459846bc084625"],"state_sha256":"3db8b598bef420858adb531472bca524e279b11f6dac067aa88ce94aaf2c308e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xwjAbIgij8NlLzordhqmg33ojbfP0l85jKUKxxO5nxKV1kSD5eWI3VvCeHwCL1njK84L6PGItVYanPcUvvqdAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-04T17:16:24.213964Z","bundle_sha256":"232a4f38e03e81ca998dba151833ad267aa4187a049c8cab0509970195349b85"}}