{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:B53UX2FK4Z4B5DSCEAYBKAEU4R","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"cbc10acf781d6afc811d76d02da2e7473fdc471a3713fe38721124d58e4de264","cross_cats_sorted":["cs.CE","cs.CV","cs.LG","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-02-01T02:08:00Z","title_canon_sha256":"a955337714dc7eae0d862884ffe336fc5f55970474d7812b37990ea3c5c58245"},"schema_version":"1.0","source":{"id":"1102.0059","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1102.0059","created_at":"2026-05-18T02:22:41Z"},{"alias_kind":"arxiv_version","alias_value":"1102.0059v2","created_at":"2026-05-18T02:22:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1102.0059","created_at":"2026-05-18T02:22:41Z"},{"alias_kind":"pith_short_12","alias_value":"B53UX2FK4Z4B","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_16","alias_value":"B53UX2FK4Z4B5DSC","created_at":"2026-05-18T12:26:24Z"},{"alias_kind":"pith_short_8","alias_value":"B53UX2FK","created_at":"2026-05-18T12:26:24Z"}],"graph_snapshots":[{"event_id":"sha256:ef85082d24afdadb96a09a75ce6c4a4d4c2d2081fae5c2f49034e7b8077c66f1","target":"graph","created_at":"2026-05-18T02:22:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Recent advances in tissue microarray technology have allowed immunohistochemistry to become a powerful medium-to-high throughput analysis tool, particularly for the validation of diagnostic and prognostic biomarkers. However, as study size grows, the manual evaluation of these assays becomes a prohibitive limitation; it vastly reduces throughput and greatly increases variability and expense. We propose an algorithm - Tissue Array Co-Occurrence Matrix Analysis (TACOMA) - for quantifying cellular phenotypes based on textural regularity summarized by local inter-pixel relationships. The algorithm","authors_text":"Beatrice Knudsen, Donghui Yan, Michael Linden, Pei Wang, Timothy Randolph","cross_cats":["cs.CE","cs.CV","cs.LG","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-02-01T02:08:00Z","title":"Statistical methods for tissue array images - algorithmic scoring and co-training"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1102.0059","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4df5e4fd252e9d6d575d2e389fdaccdf9ea199155385efc78daa65de82a925d8","target":"record","created_at":"2026-05-18T02:22:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"cbc10acf781d6afc811d76d02da2e7473fdc471a3713fe38721124d58e4de264","cross_cats_sorted":["cs.CE","cs.CV","cs.LG","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-02-01T02:08:00Z","title_canon_sha256":"a955337714dc7eae0d862884ffe336fc5f55970474d7812b37990ea3c5c58245"},"schema_version":"1.0","source":{"id":"1102.0059","kind":"arxiv","version":2}},"canonical_sha256":"0f774be8aae6781e8e422030150094e449206467e07611a00b5ff5eaceb27707","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0f774be8aae6781e8e422030150094e449206467e07611a00b5ff5eaceb27707","first_computed_at":"2026-05-18T02:22:41.518295Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:22:41.518295Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"RS9WjOVSs709Z0FYZ+fvP3G0vvP0olSWgx0m5D47qfr5mS/H5NBq7e+EGBnPk79QXohMq/tjqF/z6biNn5rWAw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:22:41.518975Z","signed_message":"canonical_sha256_bytes"},"source_id":"1102.0059","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4df5e4fd252e9d6d575d2e389fdaccdf9ea199155385efc78daa65de82a925d8","sha256:ef85082d24afdadb96a09a75ce6c4a4d4c2d2081fae5c2f49034e7b8077c66f1"],"state_sha256":"152fa067ff233d43d271452a53c3b9cff25eb6e25313ebac0d9c4ce70df16b1e"}