{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:BXN3AJEFNKL7HDPZJQ2RKVFIJE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6fe6f164008fcec0877c22db82fa8c17f5a41da91456d72b1e7ef5cb5ffb2a28","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-06-22T04:01:18Z","title_canon_sha256":"fe9541bbdeec3e007a8a92ab5e9f1a9f7ff75f74bbd7a4a41862938e093663ce"},"schema_version":"1.0","source":{"id":"2606.22823","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.22823","created_at":"2026-06-23T02:14:00Z"},{"alias_kind":"arxiv_version","alias_value":"2606.22823v1","created_at":"2026-06-23T02:14:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.22823","created_at":"2026-06-23T02:14:00Z"},{"alias_kind":"pith_short_12","alias_value":"BXN3AJEFNKL7","created_at":"2026-06-23T02:14:00Z"},{"alias_kind":"pith_short_16","alias_value":"BXN3AJEFNKL7HDPZ","created_at":"2026-06-23T02:14:00Z"},{"alias_kind":"pith_short_8","alias_value":"BXN3AJEF","created_at":"2026-06-23T02:14:00Z"}],"graph_snapshots":[{"event_id":"sha256:61a7436ba4b39b23f2be7a1acafaf7e45cfaeee48fba6b3b3df7a55d2857f2f8","target":"graph","created_at":"2026-06-23T02:14:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.22823/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Enzyme substrate interaction (ESI) prediction is a fundamental computational task for biocatalyst discovery and reaction screening in large biochemical spaces. In practical settings, ESI prediction is challenged by sparse positive supervision and low-homology distribution shift, where test enzymes share limited sequence identity with those observed during training. To address these challenges, we propose RAMMESI, a retrieval-augmented multimodal framework for robust ESI prediction. RAMMESI learns explicit pairwise enzyme-substrate representations through directional cross-modal interaction mod","authors_text":"Bingxin Zhou, Chen Liu, Guisheng Fan, Liang Hong, Ming Li, Xinyuan Wang","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-06-22T04:01:18Z","title":"Retrieval-Augmented Multimodal Learning for Enzyme-Substrate Interaction Prediction Under Low-Homology Shift"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.22823","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:248fc0497e9e99e414ef2644ab315d457757b94f922f3d543cb05e640c9486fc","target":"record","created_at":"2026-06-23T02:14:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6fe6f164008fcec0877c22db82fa8c17f5a41da91456d72b1e7ef5cb5ffb2a28","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-06-22T04:01:18Z","title_canon_sha256":"fe9541bbdeec3e007a8a92ab5e9f1a9f7ff75f74bbd7a4a41862938e093663ce"},"schema_version":"1.0","source":{"id":"2606.22823","kind":"arxiv","version":1}},"canonical_sha256":"0ddbb024856a97f38df94c351554a8491b17e6287ad6cc463973d86c5422d13c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0ddbb024856a97f38df94c351554a8491b17e6287ad6cc463973d86c5422d13c","first_computed_at":"2026-06-23T02:14:00.421031Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-23T02:14:00.421031Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nzrH9Wwa1kGGPIpZsyD33N4/Y61ZgADgKu5dVxyN4SDmbXOp1Qd9Hy+qBZ998wn/YRsifh5sBNWtRO5YqCUqBw==","signature_status":"signed_v1","signed_at":"2026-06-23T02:14:00.421433Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.22823","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:248fc0497e9e99e414ef2644ab315d457757b94f922f3d543cb05e640c9486fc","sha256:61a7436ba4b39b23f2be7a1acafaf7e45cfaeee48fba6b3b3df7a55d2857f2f8"],"state_sha256":"2070690b4278702d0c5f58c7ded2a33a1d23f74936705c49b36f9fe6b155a816"}