{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:BZRXYXQREKYMPGRGXGQ67D6HGF","short_pith_number":"pith:BZRXYXQR","canonical_record":{"source":{"id":"1509.01059","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-09-03T12:42:52Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"6c5807103347026214d0ab2da602b8fb9218647d5ee0034390c6ba37830e2039","abstract_canon_sha256":"d75e1e8f2174de6947da00dea365ef884487c77d244c7d08a0791a8324d522ce"},"schema_version":"1.0"},"canonical_sha256":"0e637c5e1122b0c79a26b9a1ef8fc731762f9e9abdda5ec6d25b5a446bf9bdb8","source":{"kind":"arxiv","id":"1509.01059","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.01059","created_at":"2026-05-18T01:34:04Z"},{"alias_kind":"arxiv_version","alias_value":"1509.01059v1","created_at":"2026-05-18T01:34:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.01059","created_at":"2026-05-18T01:34:04Z"},{"alias_kind":"pith_short_12","alias_value":"BZRXYXQREKYM","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_16","alias_value":"BZRXYXQREKYMPGRG","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_8","alias_value":"BZRXYXQR","created_at":"2026-05-18T12:29:14Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:BZRXYXQREKYMPGRGXGQ67D6HGF","target":"record","payload":{"canonical_record":{"source":{"id":"1509.01059","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-09-03T12:42:52Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"6c5807103347026214d0ab2da602b8fb9218647d5ee0034390c6ba37830e2039","abstract_canon_sha256":"d75e1e8f2174de6947da00dea365ef884487c77d244c7d08a0791a8324d522ce"},"schema_version":"1.0"},"canonical_sha256":"0e637c5e1122b0c79a26b9a1ef8fc731762f9e9abdda5ec6d25b5a446bf9bdb8","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:34:04.407047Z","signature_b64":"bSGhixm8dCV83+LW0KMjyaqHDyzMlxXhm9qax6YBgYbYuNb4VKs9k1PLmUmu0hBsE57PoloKuTOI8GAyRwvYDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"0e637c5e1122b0c79a26b9a1ef8fc731762f9e9abdda5ec6d25b5a446bf9bdb8","last_reissued_at":"2026-05-18T01:34:04.406373Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:34:04.406373Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1509.01059","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:34:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+F4mlWbPjKWALfY6GCjW4vXx1QM3esIlwuzhOqFYdvxmZrz/yZHbJThr6qwo19mpCYobhLBea4JwohMh91EYBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-27T09:23:07.836084Z"},"content_sha256":"05aee75a55832f0718862869b6383553be6c78b69cd5e85923d0d329219e538b","schema_version":"1.0","event_id":"sha256:05aee75a55832f0718862869b6383553be6c78b69cd5e85923d0d329219e538b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:BZRXYXQREKYMPGRGXGQ67D6HGF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Multiple folding pathways of proteins with shallow knots and co-translational folding","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Marek Cieplak, Mateusz Chwastyk","submitted_at":"2015-09-03T12:42:52Z","abstract_excerpt":"We study the folding process in the shallowly knotted protein MJ0366 within two variants of a structure-based model. We observe that the resulting topological pathways are much richer than identified in previous studies. In addition to the single knot-loop events, we find novel, and dominant, two-loop mechanisms. We demonstrate that folding takes place in a range of temperatures and the conditions of most successful folding are at temperatures which are higher than those required for the fastest folding. We also demonstrate that nascent conditions are more favorable to knotting than off-riboso"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.01059","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:34:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"FWAVPHngVGyDLqFnuDTZVU90fBSJ2PeFRs5+Sy2mzDXfZsVH6SKQOjVuAYFO3Lc0xGrbsrTgjVKHEPfa5C/TAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-27T09:23:07.836438Z"},"content_sha256":"c7781d7175cd8015ca8d4efcf05ab5dbe8d148ab6e783ea3e6df403a9b3722ba","schema_version":"1.0","event_id":"sha256:c7781d7175cd8015ca8d4efcf05ab5dbe8d148ab6e783ea3e6df403a9b3722ba"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/BZRXYXQREKYMPGRGXGQ67D6HGF/bundle.json","state_url":"https://pith.science/pith/BZRXYXQREKYMPGRGXGQ67D6HGF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/BZRXYXQREKYMPGRGXGQ67D6HGF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-27T09:23:07Z","links":{"resolver":"https://pith.science/pith/BZRXYXQREKYMPGRGXGQ67D6HGF","bundle":"https://pith.science/pith/BZRXYXQREKYMPGRGXGQ67D6HGF/bundle.json","state":"https://pith.science/pith/BZRXYXQREKYMPGRGXGQ67D6HGF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/BZRXYXQREKYMPGRGXGQ67D6HGF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:BZRXYXQREKYMPGRGXGQ67D6HGF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d75e1e8f2174de6947da00dea365ef884487c77d244c7d08a0791a8324d522ce","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-09-03T12:42:52Z","title_canon_sha256":"6c5807103347026214d0ab2da602b8fb9218647d5ee0034390c6ba37830e2039"},"schema_version":"1.0","source":{"id":"1509.01059","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.01059","created_at":"2026-05-18T01:34:04Z"},{"alias_kind":"arxiv_version","alias_value":"1509.01059v1","created_at":"2026-05-18T01:34:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.01059","created_at":"2026-05-18T01:34:04Z"},{"alias_kind":"pith_short_12","alias_value":"BZRXYXQREKYM","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_16","alias_value":"BZRXYXQREKYMPGRG","created_at":"2026-05-18T12:29:14Z"},{"alias_kind":"pith_short_8","alias_value":"BZRXYXQR","created_at":"2026-05-18T12:29:14Z"}],"graph_snapshots":[{"event_id":"sha256:c7781d7175cd8015ca8d4efcf05ab5dbe8d148ab6e783ea3e6df403a9b3722ba","target":"graph","created_at":"2026-05-18T01:34:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We study the folding process in the shallowly knotted protein MJ0366 within two variants of a structure-based model. We observe that the resulting topological pathways are much richer than identified in previous studies. In addition to the single knot-loop events, we find novel, and dominant, two-loop mechanisms. We demonstrate that folding takes place in a range of temperatures and the conditions of most successful folding are at temperatures which are higher than those required for the fastest folding. We also demonstrate that nascent conditions are more favorable to knotting than off-riboso","authors_text":"Marek Cieplak, Mateusz Chwastyk","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-09-03T12:42:52Z","title":"Multiple folding pathways of proteins with shallow knots and co-translational folding"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.01059","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:05aee75a55832f0718862869b6383553be6c78b69cd5e85923d0d329219e538b","target":"record","created_at":"2026-05-18T01:34:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d75e1e8f2174de6947da00dea365ef884487c77d244c7d08a0791a8324d522ce","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-09-03T12:42:52Z","title_canon_sha256":"6c5807103347026214d0ab2da602b8fb9218647d5ee0034390c6ba37830e2039"},"schema_version":"1.0","source":{"id":"1509.01059","kind":"arxiv","version":1}},"canonical_sha256":"0e637c5e1122b0c79a26b9a1ef8fc731762f9e9abdda5ec6d25b5a446bf9bdb8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"0e637c5e1122b0c79a26b9a1ef8fc731762f9e9abdda5ec6d25b5a446bf9bdb8","first_computed_at":"2026-05-18T01:34:04.406373Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:34:04.406373Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bSGhixm8dCV83+LW0KMjyaqHDyzMlxXhm9qax6YBgYbYuNb4VKs9k1PLmUmu0hBsE57PoloKuTOI8GAyRwvYDA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:34:04.407047Z","signed_message":"canonical_sha256_bytes"},"source_id":"1509.01059","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:05aee75a55832f0718862869b6383553be6c78b69cd5e85923d0d329219e538b","sha256:c7781d7175cd8015ca8d4efcf05ab5dbe8d148ab6e783ea3e6df403a9b3722ba"],"state_sha256":"1c6f9de8ef8306677056bb213001beae95b106241f9bc752cec35e1112f05e2a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"aMR4Y6+nB/jV5Ocp8CvJg+oPhKsXxovvkGBZVEGqp7AFE/BObobSCjf1Qiw22sPtqKDS7nv34Vi5MBuMw2mDBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-27T09:23:07.838366Z","bundle_sha256":"1c9e9bea1f536967f3902072dd6c4126346ff80c6ab2ff4a04e80619fbf5e0e3"}}