{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:CCXMBZZK3KHP4QYGOMEZ4WF53I","short_pith_number":"pith:CCXMBZZK","canonical_record":{"source":{"id":"1408.5803","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-08-25T15:23:20Z","cross_cats_sorted":[],"title_canon_sha256":"09e0d60a3f0c2caf202cbf423c4344802422d11cc43c2882cf7d16bfd08f929e","abstract_canon_sha256":"9aa379489c250d0a6ad966a5f0eafc554066396f54f4dcb8b5008db9676a7c3a"},"schema_version":"1.0"},"canonical_sha256":"10aec0e72ada8efe430673099e58bdda09ccc6a17a8f3a2f9dd2f038dfd7028b","source":{"kind":"arxiv","id":"1408.5803","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.5803","created_at":"2026-05-18T02:17:21Z"},{"alias_kind":"arxiv_version","alias_value":"1408.5803v2","created_at":"2026-05-18T02:17:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.5803","created_at":"2026-05-18T02:17:21Z"},{"alias_kind":"pith_short_12","alias_value":"CCXMBZZK3KHP","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_16","alias_value":"CCXMBZZK3KHP4QYG","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_8","alias_value":"CCXMBZZK","created_at":"2026-05-18T12:28:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:CCXMBZZK3KHP4QYGOMEZ4WF53I","target":"record","payload":{"canonical_record":{"source":{"id":"1408.5803","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-08-25T15:23:20Z","cross_cats_sorted":[],"title_canon_sha256":"09e0d60a3f0c2caf202cbf423c4344802422d11cc43c2882cf7d16bfd08f929e","abstract_canon_sha256":"9aa379489c250d0a6ad966a5f0eafc554066396f54f4dcb8b5008db9676a7c3a"},"schema_version":"1.0"},"canonical_sha256":"10aec0e72ada8efe430673099e58bdda09ccc6a17a8f3a2f9dd2f038dfd7028b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:17:21.916132Z","signature_b64":"gSBe6PUVDO5NoS78DAYWTJ0Y4cFxDyy/Lg0QR37M2nJbMnvwtsNVfJsQ21KnTsbdk8mfJ04YV9vdOf4i1yygAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"10aec0e72ada8efe430673099e58bdda09ccc6a17a8f3a2f9dd2f038dfd7028b","last_reissued_at":"2026-05-18T02:17:21.915488Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:17:21.915488Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1408.5803","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:17:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DcCfSxTr8QjoIsPvoOGTYk4lsRgq/ypWoyBW5FWg3rgFvTT++c+cvtFiGr4tNXxrrcF5xOc1pdyeVKBt/ihjBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T11:33:50.300167Z"},"content_sha256":"5ddcbbbe74e560885955b88dd2754d4255261111e7e24ab4290674319df4f337","schema_version":"1.0","event_id":"sha256:5ddcbbbe74e560885955b88dd2754d4255261111e7e24ab4290674319df4f337"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:CCXMBZZK3KHP4QYGOMEZ4WF53I","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Ideal gas behavior of rotamerically defined conformers in native globular proteins","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Kai Wang, Lanru Liu, Pu Tian, Qimeng Wang, Shiyang Long, Zhiming Zhang","submitted_at":"2014-08-25T15:23:20Z","abstract_excerpt":"Protein conformational transitions, which are essential for function, may be driven either by entropy or enthalpy when molecular systems comprising solute and solvent molecules are the focus. Revealing thermodynamic origin of a given molecular process is an important but difficult task, and general principles governing protein conformational distributions remain elusive. Here we demonstrate that when protein molecules are taken as thermodynamic systems and solvents being treated as the environment, conformational entropy is an excellent proxy for free energy and is sufficient to explain protei"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.5803","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:17:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NMYY5QxaG3zcSJe2pAuu6/fVSQ9CyS/Zj/4OGb5542hnX2atOireN4kP7jUWymvHHroImEZc3DvHmexhUkXeDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T11:33:50.300535Z"},"content_sha256":"5719b65bdabf1540654e845916b66541f1fdc71b8ed66d3c93b0313e36de491d","schema_version":"1.0","event_id":"sha256:5719b65bdabf1540654e845916b66541f1fdc71b8ed66d3c93b0313e36de491d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CCXMBZZK3KHP4QYGOMEZ4WF53I/bundle.json","state_url":"https://pith.science/pith/CCXMBZZK3KHP4QYGOMEZ4WF53I/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CCXMBZZK3KHP4QYGOMEZ4WF53I/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-23T11:33:50Z","links":{"resolver":"https://pith.science/pith/CCXMBZZK3KHP4QYGOMEZ4WF53I","bundle":"https://pith.science/pith/CCXMBZZK3KHP4QYGOMEZ4WF53I/bundle.json","state":"https://pith.science/pith/CCXMBZZK3KHP4QYGOMEZ4WF53I/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CCXMBZZK3KHP4QYGOMEZ4WF53I/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:CCXMBZZK3KHP4QYGOMEZ4WF53I","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9aa379489c250d0a6ad966a5f0eafc554066396f54f4dcb8b5008db9676a7c3a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-08-25T15:23:20Z","title_canon_sha256":"09e0d60a3f0c2caf202cbf423c4344802422d11cc43c2882cf7d16bfd08f929e"},"schema_version":"1.0","source":{"id":"1408.5803","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.5803","created_at":"2026-05-18T02:17:21Z"},{"alias_kind":"arxiv_version","alias_value":"1408.5803v2","created_at":"2026-05-18T02:17:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.5803","created_at":"2026-05-18T02:17:21Z"},{"alias_kind":"pith_short_12","alias_value":"CCXMBZZK3KHP","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_16","alias_value":"CCXMBZZK3KHP4QYG","created_at":"2026-05-18T12:28:22Z"},{"alias_kind":"pith_short_8","alias_value":"CCXMBZZK","created_at":"2026-05-18T12:28:22Z"}],"graph_snapshots":[{"event_id":"sha256:5719b65bdabf1540654e845916b66541f1fdc71b8ed66d3c93b0313e36de491d","target":"graph","created_at":"2026-05-18T02:17:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Protein conformational transitions, which are essential for function, may be driven either by entropy or enthalpy when molecular systems comprising solute and solvent molecules are the focus. Revealing thermodynamic origin of a given molecular process is an important but difficult task, and general principles governing protein conformational distributions remain elusive. Here we demonstrate that when protein molecules are taken as thermodynamic systems and solvents being treated as the environment, conformational entropy is an excellent proxy for free energy and is sufficient to explain protei","authors_text":"Kai Wang, Lanru Liu, Pu Tian, Qimeng Wang, Shiyang Long, Zhiming Zhang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-08-25T15:23:20Z","title":"Ideal gas behavior of rotamerically defined conformers in native globular proteins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.5803","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5ddcbbbe74e560885955b88dd2754d4255261111e7e24ab4290674319df4f337","target":"record","created_at":"2026-05-18T02:17:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9aa379489c250d0a6ad966a5f0eafc554066396f54f4dcb8b5008db9676a7c3a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-08-25T15:23:20Z","title_canon_sha256":"09e0d60a3f0c2caf202cbf423c4344802422d11cc43c2882cf7d16bfd08f929e"},"schema_version":"1.0","source":{"id":"1408.5803","kind":"arxiv","version":2}},"canonical_sha256":"10aec0e72ada8efe430673099e58bdda09ccc6a17a8f3a2f9dd2f038dfd7028b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"10aec0e72ada8efe430673099e58bdda09ccc6a17a8f3a2f9dd2f038dfd7028b","first_computed_at":"2026-05-18T02:17:21.915488Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:17:21.915488Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"gSBe6PUVDO5NoS78DAYWTJ0Y4cFxDyy/Lg0QR37M2nJbMnvwtsNVfJsQ21KnTsbdk8mfJ04YV9vdOf4i1yygAg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:17:21.916132Z","signed_message":"canonical_sha256_bytes"},"source_id":"1408.5803","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5ddcbbbe74e560885955b88dd2754d4255261111e7e24ab4290674319df4f337","sha256:5719b65bdabf1540654e845916b66541f1fdc71b8ed66d3c93b0313e36de491d"],"state_sha256":"0b5c0ec423f1068ec8ae6688416c1c4af22dda61d5c80883dd4fcbaa3eae7074"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Xor+wf00EFmqwqc+BC0I/gqVAGa1ap7+rsdF2I4yYatP4rOcReVvYBTaBoYWZTvrWQ2NXnvrvR4+cPodBX0JDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-23T11:33:50.302481Z","bundle_sha256":"470a98471c6eea97f5ba34e054f90f89213de1a55cbc75e193dc102909848956"}}