{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:CVWBJK4QYXRR7EZHHG5YCUXARS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"872ac56584c44717a263951379b6cf9dfd60e43fa00b407734e4c2af632b9c12","cross_cats_sorted":["q-bio.GN","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2009-01-19T18:07:56Z","title_canon_sha256":"ed6d1b281599fb7cebe3f7064bb528f9b297010c6f1167ab77f37518fedd741b"},"schema_version":"1.0","source":{"id":"0901.2905","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0901.2905","created_at":"2026-05-18T02:14:56Z"},{"alias_kind":"arxiv_version","alias_value":"0901.2905v1","created_at":"2026-05-18T02:14:56Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0901.2905","created_at":"2026-05-18T02:14:56Z"},{"alias_kind":"pith_short_12","alias_value":"CVWBJK4QYXRR","created_at":"2026-05-18T12:25:59Z"},{"alias_kind":"pith_short_16","alias_value":"CVWBJK4QYXRR7EZH","created_at":"2026-05-18T12:25:59Z"},{"alias_kind":"pith_short_8","alias_value":"CVWBJK4Q","created_at":"2026-05-18T12:25:59Z"}],"graph_snapshots":[{"event_id":"sha256:fc7ff5561d930edfcbcf072c4f0192d422a785103b4ea5cf726c5a557683756e","target":"graph","created_at":"2026-05-18T02:14:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes. The classical model of cooperativity requires direct interactions between TFs, thus constraining the arrangement of TFs sites in a CRR. On the contrary, genomic and functional studies demonstrate a great deal of flexibility in such arrangements with variable distances, numbers of sites, and identities of the involved TFs. Such flexibility is inconsistent with the cooperativity by direct interactions between TFs. Here we demonstrat","authors_text":"Leonid A. Mirny","cross_cats":["q-bio.GN","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2009-01-19T18:07:56Z","title":"Nucleosome-mediated cooperativity between transcription factors"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0901.2905","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c5e30baa7b384449a1aabc2b620257db931216e4eb5bc65f031e36f807c4413a","target":"record","created_at":"2026-05-18T02:14:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"872ac56584c44717a263951379b6cf9dfd60e43fa00b407734e4c2af632b9c12","cross_cats_sorted":["q-bio.GN","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2009-01-19T18:07:56Z","title_canon_sha256":"ed6d1b281599fb7cebe3f7064bb528f9b297010c6f1167ab77f37518fedd741b"},"schema_version":"1.0","source":{"id":"0901.2905","kind":"arxiv","version":1}},"canonical_sha256":"156c14ab90c5e31f932739bb8152e08caba054d994569c5e7062ce0935c15f9d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"156c14ab90c5e31f932739bb8152e08caba054d994569c5e7062ce0935c15f9d","first_computed_at":"2026-05-18T02:14:56.774619Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:14:56.774619Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oWNPjANaY49ZBgYIFUtvJpyxogAq0u0rP5GDs8wIQpQ6itFD+MfGHlhTPYIIMX6tZ2Zj+6IMcUlWVUqo9ZvqDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:14:56.775110Z","signed_message":"canonical_sha256_bytes"},"source_id":"0901.2905","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c5e30baa7b384449a1aabc2b620257db931216e4eb5bc65f031e36f807c4413a","sha256:fc7ff5561d930edfcbcf072c4f0192d422a785103b4ea5cf726c5a557683756e"],"state_sha256":"0ee638c7bfa4c66d954b700338594b67e0beb6ee4413befecfdaadc221c02d66"}