{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:E4ON2BCQAX4X567WJBFJNKVYEU","short_pith_number":"pith:E4ON2BCQ","canonical_record":{"source":{"id":"1110.4705","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2011-10-21T05:57:29Z","cross_cats_sorted":[],"title_canon_sha256":"a749b19087cae5c42abef20c8bfda532a2b76920dfcdc2c86bc93b8917d4fba9","abstract_canon_sha256":"c7b28b4cee9289e1704b18c8a7b0659c51b7d76190eb702df0d812ace7f43ef4"},"schema_version":"1.0"},"canonical_sha256":"271cdd045005f97efbf6484a96aab825315a52ff723928296dac7fb1ad491eda","source":{"kind":"arxiv","id":"1110.4705","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1110.4705","created_at":"2026-05-18T04:10:35Z"},{"alias_kind":"arxiv_version","alias_value":"1110.4705v1","created_at":"2026-05-18T04:10:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1110.4705","created_at":"2026-05-18T04:10:35Z"},{"alias_kind":"pith_short_12","alias_value":"E4ON2BCQAX4X","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_16","alias_value":"E4ON2BCQAX4X567W","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_8","alias_value":"E4ON2BCQ","created_at":"2026-05-18T12:26:26Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:E4ON2BCQAX4X567WJBFJNKVYEU","target":"record","payload":{"canonical_record":{"source":{"id":"1110.4705","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2011-10-21T05:57:29Z","cross_cats_sorted":[],"title_canon_sha256":"a749b19087cae5c42abef20c8bfda532a2b76920dfcdc2c86bc93b8917d4fba9","abstract_canon_sha256":"c7b28b4cee9289e1704b18c8a7b0659c51b7d76190eb702df0d812ace7f43ef4"},"schema_version":"1.0"},"canonical_sha256":"271cdd045005f97efbf6484a96aab825315a52ff723928296dac7fb1ad491eda","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:10:35.251395Z","signature_b64":"mb0F7EjovzBIadaf08DPpQxBaZxLxHCSwIidYObgpedlUpgV1l1WpA9aFnfDuYadgPkrq0Crc7ZU5EtiUAI3CQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"271cdd045005f97efbf6484a96aab825315a52ff723928296dac7fb1ad491eda","last_reissued_at":"2026-05-18T04:10:35.250857Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:10:35.250857Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1110.4705","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:10:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"e+xlp54/EPzjaBPtzJ+2Q3RDRc6kU94i91mxmbQD26RAYWsOheXoD74ST7wdg/BYuNOA6JaP8pVaCHWcMyTPAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-25T04:37:47.680185Z"},"content_sha256":"f879ad224f41896614c42cb1d60663c2cf757822bfc21eb5c2d9df4826fa0229","schema_version":"1.0","event_id":"sha256:f879ad224f41896614c42cb1d60663c2cf757822bfc21eb5c2d9df4826fa0229"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:E4ON2BCQAX4X567WJBFJNKVYEU","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Measuring reproducibility of high-throughput experiments","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Haiyan Huang, James B. Brown, Peter J. Bickel, Qunhua Li","submitted_at":"2011-10-21T05:57:29Z","abstract_excerpt":"Reproducibility is essential to reliable scientific discovery in high-throughput experiments. In this work we propose a unified approach to measure the reproducibility of findings identified from replicate experiments and identify putative discoveries using reproducibility. Unlike the usual scalar measures of reproducibility, our approach creates a curve, which quantitatively assesses when the findings are no longer consistent across replicates. Our curve is fitted by a copula mixture model, from which we derive a quantitative reproducibility score, which we call the \"irreproducible discovery "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1110.4705","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:10:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"i2cizCb5C1IwRKjCrvmvkxQZb24OuUXwqOyBJT1FIGebA+N4+9dVgoL4dgnoGysGFznrtrgeJHWzJvm14SZaDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-25T04:37:47.680547Z"},"content_sha256":"953ef71328126f5bf7c3bae8375a1ba8e4804bedd453d345d537101d0d9230eb","schema_version":"1.0","event_id":"sha256:953ef71328126f5bf7c3bae8375a1ba8e4804bedd453d345d537101d0d9230eb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/E4ON2BCQAX4X567WJBFJNKVYEU/bundle.json","state_url":"https://pith.science/pith/E4ON2BCQAX4X567WJBFJNKVYEU/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/E4ON2BCQAX4X567WJBFJNKVYEU/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-25T04:37:47Z","links":{"resolver":"https://pith.science/pith/E4ON2BCQAX4X567WJBFJNKVYEU","bundle":"https://pith.science/pith/E4ON2BCQAX4X567WJBFJNKVYEU/bundle.json","state":"https://pith.science/pith/E4ON2BCQAX4X567WJBFJNKVYEU/state.json","well_known_bundle":"https://pith.science/.well-known/pith/E4ON2BCQAX4X567WJBFJNKVYEU/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:E4ON2BCQAX4X567WJBFJNKVYEU","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c7b28b4cee9289e1704b18c8a7b0659c51b7d76190eb702df0d812ace7f43ef4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2011-10-21T05:57:29Z","title_canon_sha256":"a749b19087cae5c42abef20c8bfda532a2b76920dfcdc2c86bc93b8917d4fba9"},"schema_version":"1.0","source":{"id":"1110.4705","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1110.4705","created_at":"2026-05-18T04:10:35Z"},{"alias_kind":"arxiv_version","alias_value":"1110.4705v1","created_at":"2026-05-18T04:10:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1110.4705","created_at":"2026-05-18T04:10:35Z"},{"alias_kind":"pith_short_12","alias_value":"E4ON2BCQAX4X","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_16","alias_value":"E4ON2BCQAX4X567W","created_at":"2026-05-18T12:26:26Z"},{"alias_kind":"pith_short_8","alias_value":"E4ON2BCQ","created_at":"2026-05-18T12:26:26Z"}],"graph_snapshots":[{"event_id":"sha256:953ef71328126f5bf7c3bae8375a1ba8e4804bedd453d345d537101d0d9230eb","target":"graph","created_at":"2026-05-18T04:10:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Reproducibility is essential to reliable scientific discovery in high-throughput experiments. In this work we propose a unified approach to measure the reproducibility of findings identified from replicate experiments and identify putative discoveries using reproducibility. Unlike the usual scalar measures of reproducibility, our approach creates a curve, which quantitatively assesses when the findings are no longer consistent across replicates. Our curve is fitted by a copula mixture model, from which we derive a quantitative reproducibility score, which we call the \"irreproducible discovery ","authors_text":"Haiyan Huang, James B. Brown, Peter J. Bickel, Qunhua Li","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2011-10-21T05:57:29Z","title":"Measuring reproducibility of high-throughput experiments"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1110.4705","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f879ad224f41896614c42cb1d60663c2cf757822bfc21eb5c2d9df4826fa0229","target":"record","created_at":"2026-05-18T04:10:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c7b28b4cee9289e1704b18c8a7b0659c51b7d76190eb702df0d812ace7f43ef4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2011-10-21T05:57:29Z","title_canon_sha256":"a749b19087cae5c42abef20c8bfda532a2b76920dfcdc2c86bc93b8917d4fba9"},"schema_version":"1.0","source":{"id":"1110.4705","kind":"arxiv","version":1}},"canonical_sha256":"271cdd045005f97efbf6484a96aab825315a52ff723928296dac7fb1ad491eda","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"271cdd045005f97efbf6484a96aab825315a52ff723928296dac7fb1ad491eda","first_computed_at":"2026-05-18T04:10:35.250857Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:10:35.250857Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"mb0F7EjovzBIadaf08DPpQxBaZxLxHCSwIidYObgpedlUpgV1l1WpA9aFnfDuYadgPkrq0Crc7ZU5EtiUAI3CQ==","signature_status":"signed_v1","signed_at":"2026-05-18T04:10:35.251395Z","signed_message":"canonical_sha256_bytes"},"source_id":"1110.4705","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f879ad224f41896614c42cb1d60663c2cf757822bfc21eb5c2d9df4826fa0229","sha256:953ef71328126f5bf7c3bae8375a1ba8e4804bedd453d345d537101d0d9230eb"],"state_sha256":"b41ec3762ca14c6842a9c72a7b2f9122777c435047f740ad7e17422a95dd936d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"bgkygG9L+ihBcEn1AWE7LC5aHvh9Wh+lwLgVLFed1D0jC0HQ9T0+iMlKbNwV+LR58gbDLNgMiTaoOODjC4jmBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-25T04:37:47.682360Z","bundle_sha256":"f7fae7248be525f4f30b7bd5576b6c8ced112bf6710becf937be34798b912e2b"}}