{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:F2ILYQJIKS2MDY6XOGYHNMVRW2","short_pith_number":"pith:F2ILYQJI","canonical_record":{"source":{"id":"1803.03710","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-03-09T22:12:15Z","cross_cats_sorted":["cond-mat.soft"],"title_canon_sha256":"c3026cfc10702e08dc01dcd301e587c4a83e0e3fb206dcf304fd1f5c9e62054a","abstract_canon_sha256":"0a83db037c88fe8ae86b5c2657a5ac1d71a32d0ed38cca91e77aeb128dc88b2c"},"schema_version":"1.0"},"canonical_sha256":"2e90bc412854b4c1e3d771b076b2b1b697b797f1b824951ad9481dee93384fa0","source":{"kind":"arxiv","id":"1803.03710","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1803.03710","created_at":"2026-05-18T00:19:50Z"},{"alias_kind":"arxiv_version","alias_value":"1803.03710v1","created_at":"2026-05-18T00:19:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1803.03710","created_at":"2026-05-18T00:19:50Z"},{"alias_kind":"pith_short_12","alias_value":"F2ILYQJIKS2M","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_16","alias_value":"F2ILYQJIKS2MDY6X","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_8","alias_value":"F2ILYQJI","created_at":"2026-05-18T12:32:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:F2ILYQJIKS2MDY6XOGYHNMVRW2","target":"record","payload":{"canonical_record":{"source":{"id":"1803.03710","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-03-09T22:12:15Z","cross_cats_sorted":["cond-mat.soft"],"title_canon_sha256":"c3026cfc10702e08dc01dcd301e587c4a83e0e3fb206dcf304fd1f5c9e62054a","abstract_canon_sha256":"0a83db037c88fe8ae86b5c2657a5ac1d71a32d0ed38cca91e77aeb128dc88b2c"},"schema_version":"1.0"},"canonical_sha256":"2e90bc412854b4c1e3d771b076b2b1b697b797f1b824951ad9481dee93384fa0","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:19:50.639613Z","signature_b64":"Adud9ZdsuY5js5NLGH42BdK/7DWE8doekoi9GCs7pix8QFSmkxXICE/ROhsJGHWaMzP5KpM9YJiTx4fwIAprBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2e90bc412854b4c1e3d771b076b2b1b697b797f1b824951ad9481dee93384fa0","last_reissued_at":"2026-05-18T00:19:50.638909Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:19:50.638909Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1803.03710","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:19:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8syhTlfJAM8tWXhS9D3dwlSSvoZ6WweWUz1KuEQhqNn4zi00ggkJDj61ERx4yrIl4nFDBFp7UXpJU3igxGMxAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T10:58:25.749962Z"},"content_sha256":"8f51c49402b02522bbaf12967c142c7a82f310c71868eb16e1d014a07bdc5f8b","schema_version":"1.0","event_id":"sha256:8f51c49402b02522bbaf12967c142c7a82f310c71868eb16e1d014a07bdc5f8b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:F2ILYQJIKS2MDY6XOGYHNMVRW2","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Label-free imaging of cholesterol and lipid distributions in model membranes","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft"],"primary_cat":"physics.bio-ph","authors_text":"Hilton B. de Aguiar, Stephen H. Donaldson Jr.","submitted_at":"2018-03-09T22:12:15Z","abstract_excerpt":"Over recent decades, lipid membranes have become standard models for examining the biophysics and biochemistry of cell membranes. Interrogation of lipid domains within biomembranes is generally done with fluorescence microscopy via exogenous chemical probes. However, most fluorophores have limited partitioning tunability, with the majority segregating in the least biologically relevant domains (i.e., low-density liquid domains). Therefore, a molecular-level picture of the majority of non-labeled lipids forming the membrane is still elusive. Here, we present simple, label-free imaging of domain"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1803.03710","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:19:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"D4BY1VK6WnOKB/2A9rr9YnebmmR3SuNnY37mNNSbHYdpZ9z6/zNVyJ/whbjBLC/UqVFL/JCz7XvhW7fo85ugCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T10:58:25.750298Z"},"content_sha256":"0163bed8f2413ff38a6a8e70c19d46e55247f517efca28b37f0b0e21df7f25cb","schema_version":"1.0","event_id":"sha256:0163bed8f2413ff38a6a8e70c19d46e55247f517efca28b37f0b0e21df7f25cb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/F2ILYQJIKS2MDY6XOGYHNMVRW2/bundle.json","state_url":"https://pith.science/pith/F2ILYQJIKS2MDY6XOGYHNMVRW2/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/F2ILYQJIKS2MDY6XOGYHNMVRW2/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-03T10:58:25Z","links":{"resolver":"https://pith.science/pith/F2ILYQJIKS2MDY6XOGYHNMVRW2","bundle":"https://pith.science/pith/F2ILYQJIKS2MDY6XOGYHNMVRW2/bundle.json","state":"https://pith.science/pith/F2ILYQJIKS2MDY6XOGYHNMVRW2/state.json","well_known_bundle":"https://pith.science/.well-known/pith/F2ILYQJIKS2MDY6XOGYHNMVRW2/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:F2ILYQJIKS2MDY6XOGYHNMVRW2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0a83db037c88fe8ae86b5c2657a5ac1d71a32d0ed38cca91e77aeb128dc88b2c","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-03-09T22:12:15Z","title_canon_sha256":"c3026cfc10702e08dc01dcd301e587c4a83e0e3fb206dcf304fd1f5c9e62054a"},"schema_version":"1.0","source":{"id":"1803.03710","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1803.03710","created_at":"2026-05-18T00:19:50Z"},{"alias_kind":"arxiv_version","alias_value":"1803.03710v1","created_at":"2026-05-18T00:19:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1803.03710","created_at":"2026-05-18T00:19:50Z"},{"alias_kind":"pith_short_12","alias_value":"F2ILYQJIKS2M","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_16","alias_value":"F2ILYQJIKS2MDY6X","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_8","alias_value":"F2ILYQJI","created_at":"2026-05-18T12:32:22Z"}],"graph_snapshots":[{"event_id":"sha256:0163bed8f2413ff38a6a8e70c19d46e55247f517efca28b37f0b0e21df7f25cb","target":"graph","created_at":"2026-05-18T00:19:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Over recent decades, lipid membranes have become standard models for examining the biophysics and biochemistry of cell membranes. Interrogation of lipid domains within biomembranes is generally done with fluorescence microscopy via exogenous chemical probes. However, most fluorophores have limited partitioning tunability, with the majority segregating in the least biologically relevant domains (i.e., low-density liquid domains). Therefore, a molecular-level picture of the majority of non-labeled lipids forming the membrane is still elusive. Here, we present simple, label-free imaging of domain","authors_text":"Hilton B. de Aguiar, Stephen H. Donaldson Jr.","cross_cats":["cond-mat.soft"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-03-09T22:12:15Z","title":"Label-free imaging of cholesterol and lipid distributions in model membranes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1803.03710","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8f51c49402b02522bbaf12967c142c7a82f310c71868eb16e1d014a07bdc5f8b","target":"record","created_at":"2026-05-18T00:19:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0a83db037c88fe8ae86b5c2657a5ac1d71a32d0ed38cca91e77aeb128dc88b2c","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-03-09T22:12:15Z","title_canon_sha256":"c3026cfc10702e08dc01dcd301e587c4a83e0e3fb206dcf304fd1f5c9e62054a"},"schema_version":"1.0","source":{"id":"1803.03710","kind":"arxiv","version":1}},"canonical_sha256":"2e90bc412854b4c1e3d771b076b2b1b697b797f1b824951ad9481dee93384fa0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2e90bc412854b4c1e3d771b076b2b1b697b797f1b824951ad9481dee93384fa0","first_computed_at":"2026-05-18T00:19:50.638909Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:19:50.638909Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Adud9ZdsuY5js5NLGH42BdK/7DWE8doekoi9GCs7pix8QFSmkxXICE/ROhsJGHWaMzP5KpM9YJiTx4fwIAprBw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:19:50.639613Z","signed_message":"canonical_sha256_bytes"},"source_id":"1803.03710","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8f51c49402b02522bbaf12967c142c7a82f310c71868eb16e1d014a07bdc5f8b","sha256:0163bed8f2413ff38a6a8e70c19d46e55247f517efca28b37f0b0e21df7f25cb"],"state_sha256":"5c832c5592d90ff8d073b474317b5c59201b85786516615a60cfc66b9f47ff34"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"stbiMaIiEQU1KXczVMtbgWRcoyx++CjfqsWb63xOiE+/WmDAufu2cNGVEArsXbmd5QeAdHhVMxv3v0ceDI3eAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-03T10:58:25.752456Z","bundle_sha256":"7f4c115a84c665be07289d5e0b13c8000f67cf4115fd6a98a02c43e76cca356e"}}