{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:GBLPGPJXFOV3WBJ35GGOHYJAFF","short_pith_number":"pith:GBLPGPJX","canonical_record":{"source":{"id":"1503.04432","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2015-03-15T15:21:12Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"499370f9da788b6065505841fb882368beb8fef9e993290e64c5142f96508b23","abstract_canon_sha256":"fcab54b016e466614caddb3e531b727bd162202d3685e15a527d1518cdd0ea03"},"schema_version":"1.0"},"canonical_sha256":"3056f33d372babbb053be98ce3e120294b5669c6063178cb0c62ddbf1766987b","source":{"kind":"arxiv","id":"1503.04432","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1503.04432","created_at":"2026-05-18T02:23:25Z"},{"alias_kind":"arxiv_version","alias_value":"1503.04432v1","created_at":"2026-05-18T02:23:25Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.04432","created_at":"2026-05-18T02:23:25Z"},{"alias_kind":"pith_short_12","alias_value":"GBLPGPJXFOV3","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_16","alias_value":"GBLPGPJXFOV3WBJ3","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_8","alias_value":"GBLPGPJX","created_at":"2026-05-18T12:29:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:GBLPGPJXFOV3WBJ35GGOHYJAFF","target":"record","payload":{"canonical_record":{"source":{"id":"1503.04432","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2015-03-15T15:21:12Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"499370f9da788b6065505841fb882368beb8fef9e993290e64c5142f96508b23","abstract_canon_sha256":"fcab54b016e466614caddb3e531b727bd162202d3685e15a527d1518cdd0ea03"},"schema_version":"1.0"},"canonical_sha256":"3056f33d372babbb053be98ce3e120294b5669c6063178cb0c62ddbf1766987b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:23:25.060097Z","signature_b64":"mymoizi6WQZp6QSqC+rPuGoO8VN3nyTbJHlfLG163QJCA4PWepv7wKQIwDeJ2j7aR21iIqLLhNiY+XFyLGpSBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3056f33d372babbb053be98ce3e120294b5669c6063178cb0c62ddbf1766987b","last_reissued_at":"2026-05-18T02:23:25.059574Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:23:25.059574Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1503.04432","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:23:25Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xS+/Vdpv3RO3MCpV9NxV2kYF4VG+I0gOn4ic5RO6GaaRUfmMJ6H6lrK1vd7Q4buHE3kqWnsjEVa4WmH/E3mQBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-22T17:24:44.574440Z"},"content_sha256":"8bda1e644140cfdbb919ea2088b3fac3957a98a7f874c97302e11068d2784d77","schema_version":"1.0","event_id":"sha256:8bda1e644140cfdbb919ea2088b3fac3957a98a7f874c97302e11068d2784d77"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:GBLPGPJXFOV3WBJ35GGOHYJAFF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Sequence determines degree of knottedness in a coarse-grained protein model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"cond-mat.soft","authors_text":"Daniel Reith, Peter Virnau, Thomas W\\\"ust","submitted_at":"2015-03-15T15:21:12Z","abstract_excerpt":"Knots are abundant in globular homopolymers but rare in globular proteins. To shed new light on this long-standing conundrum, we study the influence of sequence on the formation of knots in proteins under native conditions within the framework of the hydrophobic-polar (HP) lattice protein model. By employing large scale Wang-Landau simulations combined with suitable Monte Carlo trial moves we show that, even though knots are still abundant on average, sequence introduces large variability in the degree of self-entanglements. Moreover, we are able to design sequences which are either almost alw"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.04432","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:23:25Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3bunuKSHxXvEUSHViTsJNKTgRX1S5Q/pgAhnPb2zwZ8egWCOjj6zelXpZg1bfrlBmYYQI1G4YRFp5YSQ4Ob2BQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-22T17:24:44.574832Z"},"content_sha256":"aa130d60a9263f5869d4504be3009a7facd65f4f7dd8e127232c0eb23af485c7","schema_version":"1.0","event_id":"sha256:aa130d60a9263f5869d4504be3009a7facd65f4f7dd8e127232c0eb23af485c7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GBLPGPJXFOV3WBJ35GGOHYJAFF/bundle.json","state_url":"https://pith.science/pith/GBLPGPJXFOV3WBJ35GGOHYJAFF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GBLPGPJXFOV3WBJ35GGOHYJAFF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-22T17:24:44Z","links":{"resolver":"https://pith.science/pith/GBLPGPJXFOV3WBJ35GGOHYJAFF","bundle":"https://pith.science/pith/GBLPGPJXFOV3WBJ35GGOHYJAFF/bundle.json","state":"https://pith.science/pith/GBLPGPJXFOV3WBJ35GGOHYJAFF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GBLPGPJXFOV3WBJ35GGOHYJAFF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:GBLPGPJXFOV3WBJ35GGOHYJAFF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fcab54b016e466614caddb3e531b727bd162202d3685e15a527d1518cdd0ea03","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2015-03-15T15:21:12Z","title_canon_sha256":"499370f9da788b6065505841fb882368beb8fef9e993290e64c5142f96508b23"},"schema_version":"1.0","source":{"id":"1503.04432","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1503.04432","created_at":"2026-05-18T02:23:25Z"},{"alias_kind":"arxiv_version","alias_value":"1503.04432v1","created_at":"2026-05-18T02:23:25Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.04432","created_at":"2026-05-18T02:23:25Z"},{"alias_kind":"pith_short_12","alias_value":"GBLPGPJXFOV3","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_16","alias_value":"GBLPGPJXFOV3WBJ3","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_8","alias_value":"GBLPGPJX","created_at":"2026-05-18T12:29:22Z"}],"graph_snapshots":[{"event_id":"sha256:aa130d60a9263f5869d4504be3009a7facd65f4f7dd8e127232c0eb23af485c7","target":"graph","created_at":"2026-05-18T02:23:25Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Knots are abundant in globular homopolymers but rare in globular proteins. To shed new light on this long-standing conundrum, we study the influence of sequence on the formation of knots in proteins under native conditions within the framework of the hydrophobic-polar (HP) lattice protein model. By employing large scale Wang-Landau simulations combined with suitable Monte Carlo trial moves we show that, even though knots are still abundant on average, sequence introduces large variability in the degree of self-entanglements. Moreover, we are able to design sequences which are either almost alw","authors_text":"Daniel Reith, Peter Virnau, Thomas W\\\"ust","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2015-03-15T15:21:12Z","title":"Sequence determines degree of knottedness in a coarse-grained protein model"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.04432","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8bda1e644140cfdbb919ea2088b3fac3957a98a7f874c97302e11068d2784d77","target":"record","created_at":"2026-05-18T02:23:25Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fcab54b016e466614caddb3e531b727bd162202d3685e15a527d1518cdd0ea03","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2015-03-15T15:21:12Z","title_canon_sha256":"499370f9da788b6065505841fb882368beb8fef9e993290e64c5142f96508b23"},"schema_version":"1.0","source":{"id":"1503.04432","kind":"arxiv","version":1}},"canonical_sha256":"3056f33d372babbb053be98ce3e120294b5669c6063178cb0c62ddbf1766987b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3056f33d372babbb053be98ce3e120294b5669c6063178cb0c62ddbf1766987b","first_computed_at":"2026-05-18T02:23:25.059574Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:23:25.059574Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"mymoizi6WQZp6QSqC+rPuGoO8VN3nyTbJHlfLG163QJCA4PWepv7wKQIwDeJ2j7aR21iIqLLhNiY+XFyLGpSBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:23:25.060097Z","signed_message":"canonical_sha256_bytes"},"source_id":"1503.04432","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8bda1e644140cfdbb919ea2088b3fac3957a98a7f874c97302e11068d2784d77","sha256:aa130d60a9263f5869d4504be3009a7facd65f4f7dd8e127232c0eb23af485c7"],"state_sha256":"335a2baf90201db6d1ff66281ebc3edcabc6fbf9302ba80ad7600950b310e42f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"i3jeSy8f5dGW2uPcfGsDgHKczD4uQ8geZ6CeEgONV047STLyqZY1CQoLOKFUs19l97HgSiXPYEbiSZhnkD+lDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-22T17:24:44.578092Z","bundle_sha256":"ccb1bc5ff39d6113b3849401af7aec42e6110be429e03e9d950220edc57ac050"}}