{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:GMRUY5IX735T76IO6CSTS7SVFI","short_pith_number":"pith:GMRUY5IX","schema_version":"1.0","canonical_sha256":"33234c7517fefb3ff90ef0a5397e552a219e44aeadb734b1e832f51ef1444f43","source":{"kind":"arxiv","id":"1808.08375","version":1},"attestation_state":"computed","paper":{"title":"Molecular dynamics simulations reveal the role of ceramicine B as novel PPAR{\\gamma} partial agonist against type 2 diabetes","license":"http://creativecommons.org/publicdomain/zero/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Bidyut Mallick","submitted_at":"2018-08-25T08:25:21Z","abstract_excerpt":"Peroxisome proliferator-activated receptors gamma (PPAR{\\gamma}) are ligand-activated controllers of various metabolic actions and insulin sensitivity. PPAR{\\gamma} is thus considered as an important target to treat type 2 diabetes. Available PPAR{\\gamma} drugs (full agonists) have robust insulin-sensitizing properties but are accompanied by severe side effects leading to complicated health problems. Here, we have used molecular docking and a molecular dynamics simulation study to find a novel PPAR{\\gamma} ligand from a natural product. Our study suggests that the inhibition of ceramicine B in"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1808.08375","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/publicdomain/zero/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-08-25T08:25:21Z","cross_cats_sorted":[],"title_canon_sha256":"2f3598d0ba97d763dae6a2cd3f2eef3005418ff0e8190076ab2dc70923153609","abstract_canon_sha256":"5740ded1e94c68049031840c6715ed0769e1780724cef63fbc7028bc81096c50"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:07:16.738490Z","signature_b64":"cDrV8inBWrv7Mc6tXb1xxbEc0RLg3Sme3YBMfrOOZmrUjg0ZKFLDN+wngC5ot0DscMZMMzvCPjOW8LjE/JiQAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"33234c7517fefb3ff90ef0a5397e552a219e44aeadb734b1e832f51ef1444f43","last_reissued_at":"2026-05-18T00:07:16.737875Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:07:16.737875Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Molecular dynamics simulations reveal the role of ceramicine B as novel PPAR{\\gamma} partial agonist against type 2 diabetes","license":"http://creativecommons.org/publicdomain/zero/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Bidyut Mallick","submitted_at":"2018-08-25T08:25:21Z","abstract_excerpt":"Peroxisome proliferator-activated receptors gamma (PPAR{\\gamma}) are ligand-activated controllers of various metabolic actions and insulin sensitivity. PPAR{\\gamma} is thus considered as an important target to treat type 2 diabetes. Available PPAR{\\gamma} drugs (full agonists) have robust insulin-sensitizing properties but are accompanied by severe side effects leading to complicated health problems. Here, we have used molecular docking and a molecular dynamics simulation study to find a novel PPAR{\\gamma} ligand from a natural product. Our study suggests that the inhibition of ceramicine B in"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1808.08375","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1808.08375","created_at":"2026-05-18T00:07:16.737964+00:00"},{"alias_kind":"arxiv_version","alias_value":"1808.08375v1","created_at":"2026-05-18T00:07:16.737964+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1808.08375","created_at":"2026-05-18T00:07:16.737964+00:00"},{"alias_kind":"pith_short_12","alias_value":"GMRUY5IX735T","created_at":"2026-05-18T12:32:25.280505+00:00"},{"alias_kind":"pith_short_16","alias_value":"GMRUY5IX735T76IO","created_at":"2026-05-18T12:32:25.280505+00:00"},{"alias_kind":"pith_short_8","alias_value":"GMRUY5IX","created_at":"2026-05-18T12:32:25.280505+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI","json":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI.json","graph_json":"https://pith.science/api/pith-number/GMRUY5IX735T76IO6CSTS7SVFI/graph.json","events_json":"https://pith.science/api/pith-number/GMRUY5IX735T76IO6CSTS7SVFI/events.json","paper":"https://pith.science/paper/GMRUY5IX"},"agent_actions":{"view_html":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI","download_json":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI.json","view_paper":"https://pith.science/paper/GMRUY5IX","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1808.08375&json=true","fetch_graph":"https://pith.science/api/pith-number/GMRUY5IX735T76IO6CSTS7SVFI/graph.json","fetch_events":"https://pith.science/api/pith-number/GMRUY5IX735T76IO6CSTS7SVFI/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI/action/timestamp_anchor","attest_storage":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI/action/storage_attestation","attest_author":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI/action/author_attestation","sign_citation":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI/action/citation_signature","submit_replication":"https://pith.science/pith/GMRUY5IX735T76IO6CSTS7SVFI/action/replication_record"}},"created_at":"2026-05-18T00:07:16.737964+00:00","updated_at":"2026-05-18T00:07:16.737964+00:00"}