{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:HBU3M24CR4DRHAK76LTT7LANIS","short_pith_number":"pith:HBU3M24C","canonical_record":{"source":{"id":"1610.02282","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2016-10-07T13:44:28Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"bc9ca34770969418c4a0e29b9ca8798f6a4380177d5c1a21242c32b92ca1b9af","abstract_canon_sha256":"a2248bfd96868d3ef91480e77009cd117a01af1c6e44ba59648416f9c8b63d9d"},"schema_version":"1.0"},"canonical_sha256":"3869b66b828f0713815ff2e73fac0d4481eb825923eed9bad78fc2261bfa6a0b","source":{"kind":"arxiv","id":"1610.02282","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1610.02282","created_at":"2026-05-18T00:51:43Z"},{"alias_kind":"arxiv_version","alias_value":"1610.02282v2","created_at":"2026-05-18T00:51:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1610.02282","created_at":"2026-05-18T00:51:43Z"},{"alias_kind":"pith_short_12","alias_value":"HBU3M24CR4DR","created_at":"2026-05-18T12:30:19Z"},{"alias_kind":"pith_short_16","alias_value":"HBU3M24CR4DRHAK7","created_at":"2026-05-18T12:30:19Z"},{"alias_kind":"pith_short_8","alias_value":"HBU3M24C","created_at":"2026-05-18T12:30:19Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:HBU3M24CR4DRHAK76LTT7LANIS","target":"record","payload":{"canonical_record":{"source":{"id":"1610.02282","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2016-10-07T13:44:28Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"bc9ca34770969418c4a0e29b9ca8798f6a4380177d5c1a21242c32b92ca1b9af","abstract_canon_sha256":"a2248bfd96868d3ef91480e77009cd117a01af1c6e44ba59648416f9c8b63d9d"},"schema_version":"1.0"},"canonical_sha256":"3869b66b828f0713815ff2e73fac0d4481eb825923eed9bad78fc2261bfa6a0b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:51:43.582812Z","signature_b64":"wGSDNsmII8BNjeo5EvzIRptiOmyifUnWxOZ9+haC8m7z7jvHHD2Tpei3mB9Urr3nF9g8mUPO6ZKcyU5F1f93Bw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3869b66b828f0713815ff2e73fac0d4481eb825923eed9bad78fc2261bfa6a0b","last_reissued_at":"2026-05-18T00:51:43.582255Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:51:43.582255Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1610.02282","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:51:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OnRCEtAGWSaIWwUs+ypUUdIn8YPso703jAlGvmvQB/LxVSenEwUzpnBn/lH7bAReP7KZ+m//sst5O/SR9w6pDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-04T04:59:19.155781Z"},"content_sha256":"8ab9c8d31a7193760db07f2465c76f8a23edae4efae797a7018b3ddc8eb1cb8d","schema_version":"1.0","event_id":"sha256:8ab9c8d31a7193760db07f2465c76f8a23edae4efae797a7018b3ddc8eb1cb8d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:HBU3M24CR4DRHAK76LTT7LANIS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Neutral Aggregation in Finite Length Genotype space","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.PE","authors_text":"Bahram Houchmandzadeh","submitted_at":"2016-10-07T13:44:28Z","abstract_excerpt":"The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness. Using the individual based model of Wright and Fisher, we compute the amplitude of neutral aggregation in the genome space, i.e., the probability of finding two individuals at genetic (hamming) distance k as a function of genome size L, population size N and mutation probability per base \\nu. In well mixed populations, we show that for N\\nu\\textless{}1/L, neutral aggregation is the dominant force and most individual"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1610.02282","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:51:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"y71BihfQ2hjM24SHGXr8x01jtTnS12yjJRs98tdHRc9bSaqUQiWxTPimUYEnElm72ifH+92LPALLBSf14SIQCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-04T04:59:19.156388Z"},"content_sha256":"2744c07be56943220360107cb5f52a69280edcde62351e52139b2f121eaad4ff","schema_version":"1.0","event_id":"sha256:2744c07be56943220360107cb5f52a69280edcde62351e52139b2f121eaad4ff"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HBU3M24CR4DRHAK76LTT7LANIS/bundle.json","state_url":"https://pith.science/pith/HBU3M24CR4DRHAK76LTT7LANIS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HBU3M24CR4DRHAK76LTT7LANIS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-04T04:59:19Z","links":{"resolver":"https://pith.science/pith/HBU3M24CR4DRHAK76LTT7LANIS","bundle":"https://pith.science/pith/HBU3M24CR4DRHAK76LTT7LANIS/bundle.json","state":"https://pith.science/pith/HBU3M24CR4DRHAK76LTT7LANIS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HBU3M24CR4DRHAK76LTT7LANIS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:HBU3M24CR4DRHAK76LTT7LANIS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a2248bfd96868d3ef91480e77009cd117a01af1c6e44ba59648416f9c8b63d9d","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2016-10-07T13:44:28Z","title_canon_sha256":"bc9ca34770969418c4a0e29b9ca8798f6a4380177d5c1a21242c32b92ca1b9af"},"schema_version":"1.0","source":{"id":"1610.02282","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1610.02282","created_at":"2026-05-18T00:51:43Z"},{"alias_kind":"arxiv_version","alias_value":"1610.02282v2","created_at":"2026-05-18T00:51:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1610.02282","created_at":"2026-05-18T00:51:43Z"},{"alias_kind":"pith_short_12","alias_value":"HBU3M24CR4DR","created_at":"2026-05-18T12:30:19Z"},{"alias_kind":"pith_short_16","alias_value":"HBU3M24CR4DRHAK7","created_at":"2026-05-18T12:30:19Z"},{"alias_kind":"pith_short_8","alias_value":"HBU3M24C","created_at":"2026-05-18T12:30:19Z"}],"graph_snapshots":[{"event_id":"sha256:2744c07be56943220360107cb5f52a69280edcde62351e52139b2f121eaad4ff","target":"graph","created_at":"2026-05-18T00:51:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness. Using the individual based model of Wright and Fisher, we compute the amplitude of neutral aggregation in the genome space, i.e., the probability of finding two individuals at genetic (hamming) distance k as a function of genome size L, population size N and mutation probability per base \\nu. In well mixed populations, we show that for N\\nu\\textless{}1/L, neutral aggregation is the dominant force and most individual","authors_text":"Bahram Houchmandzadeh","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2016-10-07T13:44:28Z","title":"Neutral Aggregation in Finite Length Genotype space"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1610.02282","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8ab9c8d31a7193760db07f2465c76f8a23edae4efae797a7018b3ddc8eb1cb8d","target":"record","created_at":"2026-05-18T00:51:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a2248bfd96868d3ef91480e77009cd117a01af1c6e44ba59648416f9c8b63d9d","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2016-10-07T13:44:28Z","title_canon_sha256":"bc9ca34770969418c4a0e29b9ca8798f6a4380177d5c1a21242c32b92ca1b9af"},"schema_version":"1.0","source":{"id":"1610.02282","kind":"arxiv","version":2}},"canonical_sha256":"3869b66b828f0713815ff2e73fac0d4481eb825923eed9bad78fc2261bfa6a0b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3869b66b828f0713815ff2e73fac0d4481eb825923eed9bad78fc2261bfa6a0b","first_computed_at":"2026-05-18T00:51:43.582255Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:51:43.582255Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"wGSDNsmII8BNjeo5EvzIRptiOmyifUnWxOZ9+haC8m7z7jvHHD2Tpei3mB9Urr3nF9g8mUPO6ZKcyU5F1f93Bw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:51:43.582812Z","signed_message":"canonical_sha256_bytes"},"source_id":"1610.02282","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8ab9c8d31a7193760db07f2465c76f8a23edae4efae797a7018b3ddc8eb1cb8d","sha256:2744c07be56943220360107cb5f52a69280edcde62351e52139b2f121eaad4ff"],"state_sha256":"a08f30a6740ec8409c4c6294b10d6743265bc31b6f9e91301b285a49ddcc18e4"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"F8YKHY0vc6BIBvmpYvYNE6IE39yVtfjM7Kpjviufcln/nK1ixBiszQhvkhcNfr4AwoajZXoUqYVc+UPWufpRBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-04T04:59:19.159739Z","bundle_sha256":"7623d0be77a015fc9643dfbefccb687d864b59f7b9c14712c35f0e427d328155"}}