{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2017:HGOQ3VJDABCHL6JBHPGXVWEA5O","short_pith_number":"pith:HGOQ3VJD","schema_version":"1.0","canonical_sha256":"399d0dd523004475f9213bcd7ad880ebb7bfa35bc652da27f20b5386734850e8","source":{"kind":"arxiv","id":"1704.06225","version":1},"attestation_state":"computed","paper":{"title":"Controlling the shape of membrane protein polyhedra","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Christoph A. Haselwandter, Di Li, Osman Kahraman","submitted_at":"2017-04-20T16:50:41Z","abstract_excerpt":"Membrane proteins and lipids can self-assemble into membrane protein polyhedral nanoparticles (MPPNs). MPPNs have a closed spherical surface and a polyhedral protein arrangement, and may offer a new route for structure determination of membrane proteins and targeted drug delivery. We develop here a general analytic model of how MPPN self-assembly depends on bilayer-protein interactions and lipid bilayer mechanical properties. We find that the bilayer-protein hydrophobic thickness mismatch is a key molecular control parameter for MPPN shape that can be used to bias MPPN self-assembly towards hi"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1704.06225","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-20T16:50:41Z","cross_cats_sorted":[],"title_canon_sha256":"aad61c74548d5e08d6afed19924b8898686457605625cc596b0a8758845a3eb7","abstract_canon_sha256":"0b5f20c47345f04fe593e26112e0e1b11dc1608e7604ab29cc51720a1ee6e0ab"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:45:29.863334Z","signature_b64":"Ap9ziJf0HW20Ry9Yh9z91aKR33An2v3UOI2utBUR6hKTXF6scRaXRRn04iY8XfMcXfn6wPk5eRXy6I1ZzJbpDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"399d0dd523004475f9213bcd7ad880ebb7bfa35bc652da27f20b5386734850e8","last_reissued_at":"2026-05-18T00:45:29.862873Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:45:29.862873Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Controlling the shape of membrane protein polyhedra","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Christoph A. Haselwandter, Di Li, Osman Kahraman","submitted_at":"2017-04-20T16:50:41Z","abstract_excerpt":"Membrane proteins and lipids can self-assemble into membrane protein polyhedral nanoparticles (MPPNs). MPPNs have a closed spherical surface and a polyhedral protein arrangement, and may offer a new route for structure determination of membrane proteins and targeted drug delivery. We develop here a general analytic model of how MPPN self-assembly depends on bilayer-protein interactions and lipid bilayer mechanical properties. We find that the bilayer-protein hydrophobic thickness mismatch is a key molecular control parameter for MPPN shape that can be used to bias MPPN self-assembly towards hi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.06225","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1704.06225","created_at":"2026-05-18T00:45:29.862938+00:00"},{"alias_kind":"arxiv_version","alias_value":"1704.06225v1","created_at":"2026-05-18T00:45:29.862938+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.06225","created_at":"2026-05-18T00:45:29.862938+00:00"},{"alias_kind":"pith_short_12","alias_value":"HGOQ3VJDABCH","created_at":"2026-05-18T12:31:18.294218+00:00"},{"alias_kind":"pith_short_16","alias_value":"HGOQ3VJDABCHL6JB","created_at":"2026-05-18T12:31:18.294218+00:00"},{"alias_kind":"pith_short_8","alias_value":"HGOQ3VJD","created_at":"2026-05-18T12:31:18.294218+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O","json":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O.json","graph_json":"https://pith.science/api/pith-number/HGOQ3VJDABCHL6JBHPGXVWEA5O/graph.json","events_json":"https://pith.science/api/pith-number/HGOQ3VJDABCHL6JBHPGXVWEA5O/events.json","paper":"https://pith.science/paper/HGOQ3VJD"},"agent_actions":{"view_html":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O","download_json":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O.json","view_paper":"https://pith.science/paper/HGOQ3VJD","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1704.06225&json=true","fetch_graph":"https://pith.science/api/pith-number/HGOQ3VJDABCHL6JBHPGXVWEA5O/graph.json","fetch_events":"https://pith.science/api/pith-number/HGOQ3VJDABCHL6JBHPGXVWEA5O/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O/action/timestamp_anchor","attest_storage":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O/action/storage_attestation","attest_author":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O/action/author_attestation","sign_citation":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O/action/citation_signature","submit_replication":"https://pith.science/pith/HGOQ3VJDABCHL6JBHPGXVWEA5O/action/replication_record"}},"created_at":"2026-05-18T00:45:29.862938+00:00","updated_at":"2026-05-18T00:45:29.862938+00:00"}