{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:HUQ556VYC2LOIADRE3LHHAW4R4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a501ddcf01be039d708140093fb267ab9e1079ea1292e5f50eb0f0538ba8b5e5","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-01-15T19:13:39Z","title_canon_sha256":"88a52db31f68df72a99d4303be7f557aba655edf6037d60d849180b1d8eedfc9"},"schema_version":"1.0","source":{"id":"2501.09087","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2501.09087","created_at":"2026-07-05T12:09:43Z"},{"alias_kind":"arxiv_version","alias_value":"2501.09087v2","created_at":"2026-07-05T12:09:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2501.09087","created_at":"2026-07-05T12:09:43Z"},{"alias_kind":"pith_short_12","alias_value":"HUQ556VYC2LO","created_at":"2026-07-05T12:09:43Z"},{"alias_kind":"pith_short_16","alias_value":"HUQ556VYC2LOIADR","created_at":"2026-07-05T12:09:43Z"},{"alias_kind":"pith_short_8","alias_value":"HUQ556VY","created_at":"2026-07-05T12:09:43Z"}],"graph_snapshots":[{"event_id":"sha256:bb051cad48c975ffbcf7d8030bae7731c29fd369eb9ba60d5d92705e6b6d959b","target":"graph","created_at":"2026-07-05T12:09:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2501.09087/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"A fluctuation theorem is examined for the first-passage time of a biomolecular machine (e.g., a motor protein or an enzyme) in a nonequilibrium steady-state. For such machines in which the driven, observable process is coupled to a hidden process in a kinetically cooperative fashion, the entropy produced along first-passage trajectories is no longer constant, resulting in a breakdown of this expression. Here, we consider the canonical model for this type of system, a kinetic scheme for conformation-modulated single-enzyme catalysis (a type of continuous-time Markov process with relevance to $\\","authors_text":"D. Evan Piephoff, Jianshu Cao","cross_cats":["physics.chem-ph","q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-01-15T19:13:39Z","title":"First-Passage Time Fluctuation Theorem and Thermodynamic Bound in Cooperative Biomolecular Networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2501.09087","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:264677a4e3e49dc8c598b27d05d0211b272c6c8537c8d5911abb2569d7274e41","target":"record","created_at":"2026-07-05T12:09:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a501ddcf01be039d708140093fb267ab9e1079ea1292e5f50eb0f0538ba8b5e5","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-01-15T19:13:39Z","title_canon_sha256":"88a52db31f68df72a99d4303be7f557aba655edf6037d60d849180b1d8eedfc9"},"schema_version":"1.0","source":{"id":"2501.09087","kind":"arxiv","version":2}},"canonical_sha256":"3d21defab81696e4007126d67382dc8f171bc2e5bff813ba5b83ac46b900f120","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3d21defab81696e4007126d67382dc8f171bc2e5bff813ba5b83ac46b900f120","first_computed_at":"2026-07-05T12:09:43.344152Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T12:09:43.344152Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"fMmGwWCb6s8gYUG5gjaaE7BB3AS6PlvzRS2hsdDtyAafG7yoXw/cK0s28LDF6gCPZT1CsTAHkWZ0mE1xSvYzDw==","signature_status":"signed_v1","signed_at":"2026-07-05T12:09:43.344876Z","signed_message":"canonical_sha256_bytes"},"source_id":"2501.09087","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:264677a4e3e49dc8c598b27d05d0211b272c6c8537c8d5911abb2569d7274e41","sha256:bb051cad48c975ffbcf7d8030bae7731c29fd369eb9ba60d5d92705e6b6d959b"],"state_sha256":"bd525bd51535f178550f881855ecdfb3da2971880beb0640690a3df3cd1e702c"}