{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:HZUJPNSTMFNKFMXXBN563GYDGT","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f7ee559c36c6000e52322936cb1cda151b89854552395c285dd71f27dbf5d77a","cross_cats_sorted":["q-bio.OT"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2025-05-18T07:50:51Z","title_canon_sha256":"df7c16a5433d89ba6430e30ccb7b8a41c6983bc9d4c61cbedc1d2d7c3cc82682"},"schema_version":"1.0","source":{"id":"2505.12286","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.12286","created_at":"2026-06-08T01:03:44Z"},{"alias_kind":"arxiv_version","alias_value":"2505.12286v2","created_at":"2026-06-08T01:03:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.12286","created_at":"2026-06-08T01:03:44Z"},{"alias_kind":"pith_short_12","alias_value":"HZUJPNSTMFNK","created_at":"2026-06-08T01:03:44Z"},{"alias_kind":"pith_short_16","alias_value":"HZUJPNSTMFNKFMXX","created_at":"2026-06-08T01:03:44Z"},{"alias_kind":"pith_short_8","alias_value":"HZUJPNST","created_at":"2026-06-08T01:03:44Z"}],"graph_snapshots":[{"event_id":"sha256:440f9120dff038b6abe1d38ca8f526bb07d2d41dc715414a239415e71e641b08","target":"graph","created_at":"2026-06-08T01:03:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.12286/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The entry inhibitor Bulevirtide (BLV) was recently approved in Europe for treatment of chronic hepatitis D virus (HDV) infection, which is considered the most severe viral hepatitis infection. Theory indicates that models that account for free virus and infected cells, but do not include target cell dynamics (historically called the two-equation model) are limited to predicting a monophasic viral decline for antiviral agents that act only to block viral entry/infection. We investigated herein a recently published two-equation type model against clinical data obtained from patients with HDV tre","authors_text":"Adquate Mhlanga, Annapaola Callegaro, Ashish Goyal, Dana Sambarino, Elisabetta Degasperi, Floriana Facchetti, Harel Dahari, Louis Shekhtman, Maria Paola Anolli, Marta Borghi, Pietro Lampertico, Riccardo Perbellini, Sara Colonia Uceda Renteria, Scott J. Cotler","cross_cats":["q-bio.OT"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2025-05-18T07:50:51Z","title":"Modeling hepatitis D virus kinetics during bulevirtide monotherapy: challenges and solutions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.12286","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6dbbf7ef30416115ac35ba53c3c1c9313705c3d9ad28fb99abbdb27e5b7fcfa0","target":"record","created_at":"2026-06-08T01:03:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f7ee559c36c6000e52322936cb1cda151b89854552395c285dd71f27dbf5d77a","cross_cats_sorted":["q-bio.OT"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.soc-ph","submitted_at":"2025-05-18T07:50:51Z","title_canon_sha256":"df7c16a5433d89ba6430e30ccb7b8a41c6983bc9d4c61cbedc1d2d7c3cc82682"},"schema_version":"1.0","source":{"id":"2505.12286","kind":"arxiv","version":2}},"canonical_sha256":"3e6897b653615aa2b2f70b7bed9b0334c92e9d4b2d26a50bdbe13669eb3e9c3b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3e6897b653615aa2b2f70b7bed9b0334c92e9d4b2d26a50bdbe13669eb3e9c3b","first_computed_at":"2026-06-08T01:03:44.765716Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-08T01:03:44.765716Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"6bgZ7NL0IMjdJd2zgSb7CBpMiZJgGgvAkJ1DOXHgNIHtilBV2A3jp8c3HLbDpcsX6+6/ISUOIZsaZsTNxEylCA==","signature_status":"signed_v1","signed_at":"2026-06-08T01:03:44.766755Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.12286","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6dbbf7ef30416115ac35ba53c3c1c9313705c3d9ad28fb99abbdb27e5b7fcfa0","sha256:440f9120dff038b6abe1d38ca8f526bb07d2d41dc715414a239415e71e641b08"],"state_sha256":"bc3a876db6b0346c27bd3d9766de910726b202d27d892540a9c70e05ef903a3b"}