{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:I5DD5MFJ43VPWTV3AXWCR6F6QE","short_pith_number":"pith:I5DD5MFJ","schema_version":"1.0","canonical_sha256":"47463eb0a9e6eafb4ebb05ec28f8be8122314287b601233b1ac6953168a84bf3","source":{"kind":"arxiv","id":"1504.07266","version":3},"attestation_state":"computed","paper":{"title":"Entropy, Ergodicity and Stem Cell Multipotency","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.CB","authors_text":"Ben D. MacArthur, Hannah H. Chang, Konstantinos C. Zygalakis, Sonya J. Ridden","submitted_at":"2015-04-27T20:22:12Z","abstract_excerpt":"Populations of mammalian stem cells commonly exhibit considerable cell-cell variability. However, the functional role of this diversity is unclear. Here, we analyze expression fluctuations of the stem cell surface marker Sca1 in mouse hematopoietic progenitor cells using a simple stochastic model and find that the observed dynamics naturally lie close to a critical state, thereby producing a diverse population that is able to respond rapidly to environmental changes. We propose an information-theoretic interpretation of these results that views cellular multipotency as an instance of maximum e"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1504.07266","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2015-04-27T20:22:12Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"10678c2dc619252fc8dd36aeaa11ab28fcb959a42778e317d45d60a31cdd93f0","abstract_canon_sha256":"320fefb6cfb634369f2466a6beff81dd5f5199b332c8a7e9cff228dd107df189"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:29:54.302590Z","signature_b64":"COLH4zNRd0Mpwa2RvIBBwfHZnnj3eKr+4XgwCOcSDG/i5x5z5LkKQyndW9eQwbqiLDvLHy9R0lPtYpYIQDvNCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"47463eb0a9e6eafb4ebb05ec28f8be8122314287b601233b1ac6953168a84bf3","last_reissued_at":"2026-05-18T01:29:54.302076Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:29:54.302076Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Entropy, Ergodicity and Stem Cell Multipotency","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.CB","authors_text":"Ben D. MacArthur, Hannah H. Chang, Konstantinos C. Zygalakis, Sonya J. Ridden","submitted_at":"2015-04-27T20:22:12Z","abstract_excerpt":"Populations of mammalian stem cells commonly exhibit considerable cell-cell variability. However, the functional role of this diversity is unclear. Here, we analyze expression fluctuations of the stem cell surface marker Sca1 in mouse hematopoietic progenitor cells using a simple stochastic model and find that the observed dynamics naturally lie close to a critical state, thereby producing a diverse population that is able to respond rapidly to environmental changes. We propose an information-theoretic interpretation of these results that views cellular multipotency as an instance of maximum e"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1504.07266","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1504.07266","created_at":"2026-05-18T01:29:54.302168+00:00"},{"alias_kind":"arxiv_version","alias_value":"1504.07266v3","created_at":"2026-05-18T01:29:54.302168+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1504.07266","created_at":"2026-05-18T01:29:54.302168+00:00"},{"alias_kind":"pith_short_12","alias_value":"I5DD5MFJ43VP","created_at":"2026-05-18T12:29:25.134429+00:00"},{"alias_kind":"pith_short_16","alias_value":"I5DD5MFJ43VPWTV3","created_at":"2026-05-18T12:29:25.134429+00:00"},{"alias_kind":"pith_short_8","alias_value":"I5DD5MFJ","created_at":"2026-05-18T12:29:25.134429+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE","json":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE.json","graph_json":"https://pith.science/api/pith-number/I5DD5MFJ43VPWTV3AXWCR6F6QE/graph.json","events_json":"https://pith.science/api/pith-number/I5DD5MFJ43VPWTV3AXWCR6F6QE/events.json","paper":"https://pith.science/paper/I5DD5MFJ"},"agent_actions":{"view_html":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE","download_json":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE.json","view_paper":"https://pith.science/paper/I5DD5MFJ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1504.07266&json=true","fetch_graph":"https://pith.science/api/pith-number/I5DD5MFJ43VPWTV3AXWCR6F6QE/graph.json","fetch_events":"https://pith.science/api/pith-number/I5DD5MFJ43VPWTV3AXWCR6F6QE/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE/action/timestamp_anchor","attest_storage":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE/action/storage_attestation","attest_author":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE/action/author_attestation","sign_citation":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE/action/citation_signature","submit_replication":"https://pith.science/pith/I5DD5MFJ43VPWTV3AXWCR6F6QE/action/replication_record"}},"created_at":"2026-05-18T01:29:54.302168+00:00","updated_at":"2026-05-18T01:29:54.302168+00:00"}