{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:INBNCPMA5MDI5WMB34YA7ZEGSO","short_pith_number":"pith:INBNCPMA","canonical_record":{"source":{"id":"1609.06547","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-13T13:30:25Z","cross_cats_sorted":[],"title_canon_sha256":"2eb03228c5527f6dfdf13fbef90558e90dc0c02414e12c86fd250eb8c7155d78","abstract_canon_sha256":"6315327a6ddf9c7e13cfc45cb3caa5dacdf13e55eaa51df7996299c412238da6"},"schema_version":"1.0"},"canonical_sha256":"4342d13d80eb068ed981df300fe48693b6f4075b21365a242d0c0118b02afa7c","source":{"kind":"arxiv","id":"1609.06547","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1609.06547","created_at":"2026-05-18T00:45:15Z"},{"alias_kind":"arxiv_version","alias_value":"1609.06547v2","created_at":"2026-05-18T00:45:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.06547","created_at":"2026-05-18T00:45:15Z"},{"alias_kind":"pith_short_12","alias_value":"INBNCPMA5MDI","created_at":"2026-05-18T12:30:22Z"},{"alias_kind":"pith_short_16","alias_value":"INBNCPMA5MDI5WMB","created_at":"2026-05-18T12:30:22Z"},{"alias_kind":"pith_short_8","alias_value":"INBNCPMA","created_at":"2026-05-18T12:30:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:INBNCPMA5MDI5WMB34YA7ZEGSO","target":"record","payload":{"canonical_record":{"source":{"id":"1609.06547","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-13T13:30:25Z","cross_cats_sorted":[],"title_canon_sha256":"2eb03228c5527f6dfdf13fbef90558e90dc0c02414e12c86fd250eb8c7155d78","abstract_canon_sha256":"6315327a6ddf9c7e13cfc45cb3caa5dacdf13e55eaa51df7996299c412238da6"},"schema_version":"1.0"},"canonical_sha256":"4342d13d80eb068ed981df300fe48693b6f4075b21365a242d0c0118b02afa7c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:45:15.440958Z","signature_b64":"sYWOwWhS/QD3lcJkBIKbLEkuVt7b3IfLFp9U/bHWKDIMpFCnfASvB3D+ugYjTur0az/jvI78eLy6GDCAmNhwAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4342d13d80eb068ed981df300fe48693b6f4075b21365a242d0c0118b02afa7c","last_reissued_at":"2026-05-18T00:45:15.440293Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:45:15.440293Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1609.06547","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:45:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"257INaH09GznHJtHw+Bpgc93RQPGhD5U1d0ks+ibB8TcV8r49lIPZDmzjh74YYPCQTrzL7EY7u2XQbtp/UrEAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-15T12:05:43.587751Z"},"content_sha256":"b5df5bcb313845234a6b6ee68e0889c79f8b341dda85b4554c9ad6656a7e16bb","schema_version":"1.0","event_id":"sha256:b5df5bcb313845234a6b6ee68e0889c79f8b341dda85b4554c9ad6656a7e16bb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:INBNCPMA5MDI5WMB34YA7ZEGSO","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A high-throughput analysis of ovarian cycle disruption by mixtures of aromatase inhibitors","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.TO","authors_text":"Cleo Tebby, Emmanuel Lemazurier, Frederic Y. Bois, Henry A. Gabb, Nazanin Golbamaki-Bakhtyari, Simona Kovarich","submitted_at":"2016-09-13T13:30:25Z","abstract_excerpt":"Background: Combining computational toxicology with ExpoCast exposure estimates and ToxCast assay data gives us access to predictions of human health risks stemming from exposures to chemical mixtures.\n  Objectives: To explore, through mathematical modeling and simulations, the size of potential effects of random mixtures of aromatase inhibitors on the dynamics of women's menstrual cycles.\n  Methods: We simulated random exposures to millions of potential mixtures of 86 aromatase inhibitors. A pharmacokinetic model of intake and disposition of the chemicals predicted their internal concentratio"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.06547","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:45:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YF5ZvWi290pG0TWwgO3POfAoVAAoi72+q5yNdQ5Fy+tRmN7amOwh+C8id7HfTda2tay1LMaJd7z6BWXXlatpDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-15T12:05:43.588209Z"},"content_sha256":"3226b721a9e5c4e72938dd525c5db91e341afe25d3384d6e8aa5156db89dfa39","schema_version":"1.0","event_id":"sha256:3226b721a9e5c4e72938dd525c5db91e341afe25d3384d6e8aa5156db89dfa39"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/INBNCPMA5MDI5WMB34YA7ZEGSO/bundle.json","state_url":"https://pith.science/pith/INBNCPMA5MDI5WMB34YA7ZEGSO/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/INBNCPMA5MDI5WMB34YA7ZEGSO/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-15T12:05:43Z","links":{"resolver":"https://pith.science/pith/INBNCPMA5MDI5WMB34YA7ZEGSO","bundle":"https://pith.science/pith/INBNCPMA5MDI5WMB34YA7ZEGSO/bundle.json","state":"https://pith.science/pith/INBNCPMA5MDI5WMB34YA7ZEGSO/state.json","well_known_bundle":"https://pith.science/.well-known/pith/INBNCPMA5MDI5WMB34YA7ZEGSO/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:INBNCPMA5MDI5WMB34YA7ZEGSO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6315327a6ddf9c7e13cfc45cb3caa5dacdf13e55eaa51df7996299c412238da6","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-13T13:30:25Z","title_canon_sha256":"2eb03228c5527f6dfdf13fbef90558e90dc0c02414e12c86fd250eb8c7155d78"},"schema_version":"1.0","source":{"id":"1609.06547","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1609.06547","created_at":"2026-05-18T00:45:15Z"},{"alias_kind":"arxiv_version","alias_value":"1609.06547v2","created_at":"2026-05-18T00:45:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.06547","created_at":"2026-05-18T00:45:15Z"},{"alias_kind":"pith_short_12","alias_value":"INBNCPMA5MDI","created_at":"2026-05-18T12:30:22Z"},{"alias_kind":"pith_short_16","alias_value":"INBNCPMA5MDI5WMB","created_at":"2026-05-18T12:30:22Z"},{"alias_kind":"pith_short_8","alias_value":"INBNCPMA","created_at":"2026-05-18T12:30:22Z"}],"graph_snapshots":[{"event_id":"sha256:3226b721a9e5c4e72938dd525c5db91e341afe25d3384d6e8aa5156db89dfa39","target":"graph","created_at":"2026-05-18T00:45:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Background: Combining computational toxicology with ExpoCast exposure estimates and ToxCast assay data gives us access to predictions of human health risks stemming from exposures to chemical mixtures.\n  Objectives: To explore, through mathematical modeling and simulations, the size of potential effects of random mixtures of aromatase inhibitors on the dynamics of women's menstrual cycles.\n  Methods: We simulated random exposures to millions of potential mixtures of 86 aromatase inhibitors. A pharmacokinetic model of intake and disposition of the chemicals predicted their internal concentratio","authors_text":"Cleo Tebby, Emmanuel Lemazurier, Frederic Y. Bois, Henry A. Gabb, Nazanin Golbamaki-Bakhtyari, Simona Kovarich","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-13T13:30:25Z","title":"A high-throughput analysis of ovarian cycle disruption by mixtures of aromatase inhibitors"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.06547","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b5df5bcb313845234a6b6ee68e0889c79f8b341dda85b4554c9ad6656a7e16bb","target":"record","created_at":"2026-05-18T00:45:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6315327a6ddf9c7e13cfc45cb3caa5dacdf13e55eaa51df7996299c412238da6","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-13T13:30:25Z","title_canon_sha256":"2eb03228c5527f6dfdf13fbef90558e90dc0c02414e12c86fd250eb8c7155d78"},"schema_version":"1.0","source":{"id":"1609.06547","kind":"arxiv","version":2}},"canonical_sha256":"4342d13d80eb068ed981df300fe48693b6f4075b21365a242d0c0118b02afa7c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4342d13d80eb068ed981df300fe48693b6f4075b21365a242d0c0118b02afa7c","first_computed_at":"2026-05-18T00:45:15.440293Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:45:15.440293Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"sYWOwWhS/QD3lcJkBIKbLEkuVt7b3IfLFp9U/bHWKDIMpFCnfASvB3D+ugYjTur0az/jvI78eLy6GDCAmNhwAA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:45:15.440958Z","signed_message":"canonical_sha256_bytes"},"source_id":"1609.06547","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b5df5bcb313845234a6b6ee68e0889c79f8b341dda85b4554c9ad6656a7e16bb","sha256:3226b721a9e5c4e72938dd525c5db91e341afe25d3384d6e8aa5156db89dfa39"],"state_sha256":"79bd55ad6dfa7f18480bd6fdca7c3388aadc196910f36aa3da6d52f76123ec21"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"djC5KCtACldl5uQ+OKa5F0kjV7rnIRLgvtM9BILE0kom/2huiSpVf9FFWos5zPf9gKZbpntkJ2H2vsqyA+U3DA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-15T12:05:43.593049Z","bundle_sha256":"b6dbc379cb6cdf0bd3622948cb9e0038003b2bce3373cebc021c46432101585a"}}