{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2010:JFVLHVOIP5ZC66KSGG6CW6ZH4P","short_pith_number":"pith:JFVLHVOI","schema_version":"1.0","canonical_sha256":"496ab3d5c87f722f795231bc2b7b27e3caca0d33d3d1ad36da3ac4164f06bf29","source":{"kind":"arxiv","id":"1007.3447","version":2},"attestation_state":"computed","paper":{"title":"Inference of plasmid copy number mean and noise from single cell gene expression data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.QM"],"primary_cat":"q-bio.CB","authors_text":"Didier Chatenay, J\\'er\\^ome Robert, J\\'er\\^ome Wong Ng, St\\'ephane Ghozzi","submitted_at":"2010-07-20T15:25:12Z","abstract_excerpt":"Plasmids are extra-chromosomal DNA molecules which code for their own replication. We previously reported a setup using genes coding for fluorescent proteins of two colors that allowed us, using a simple model, to extract the plasmid copy number noise in a monoclonal population of bacteria [J. Wong Ng et al., Phys. Rev. E, 81, 011909 (2010)]. Here we present a detailed calculation relating this noise to the measured levels of fluorescence, taking into account all sources of fluorescence fluctuations: the fluctuation of gene expression as in the simple model, but also the growth and division of"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1007.3447","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2010-07-20T15:25:12Z","cross_cats_sorted":["physics.bio-ph","q-bio.QM"],"title_canon_sha256":"00fb3ea55663f782ba8426b24e3e94ae1fc9fc67af7d4d43b18993cffc62194a","abstract_canon_sha256":"dc1313da08dbcb1f922b47cd416b69b2353f36bcc6216258260fe5484b05d744"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:35:48.845786Z","signature_b64":"kAeO7HwhazKVakPD8g8ApwDQnrosg6R6eLSVk/8hjNAmIHyt2E8VMnVv6hrHuBqGwXbujqDDYUsjqdlol64uBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"496ab3d5c87f722f795231bc2b7b27e3caca0d33d3d1ad36da3ac4164f06bf29","last_reissued_at":"2026-05-18T04:35:48.845329Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:35:48.845329Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Inference of plasmid copy number mean and noise from single cell gene expression data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.QM"],"primary_cat":"q-bio.CB","authors_text":"Didier Chatenay, J\\'er\\^ome Robert, J\\'er\\^ome Wong Ng, St\\'ephane Ghozzi","submitted_at":"2010-07-20T15:25:12Z","abstract_excerpt":"Plasmids are extra-chromosomal DNA molecules which code for their own replication. We previously reported a setup using genes coding for fluorescent proteins of two colors that allowed us, using a simple model, to extract the plasmid copy number noise in a monoclonal population of bacteria [J. Wong Ng et al., Phys. Rev. E, 81, 011909 (2010)]. Here we present a detailed calculation relating this noise to the measured levels of fluorescence, taking into account all sources of fluorescence fluctuations: the fluctuation of gene expression as in the simple model, but also the growth and division of"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1007.3447","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1007.3447","created_at":"2026-05-18T04:35:48.845390+00:00"},{"alias_kind":"arxiv_version","alias_value":"1007.3447v2","created_at":"2026-05-18T04:35:48.845390+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1007.3447","created_at":"2026-05-18T04:35:48.845390+00:00"},{"alias_kind":"pith_short_12","alias_value":"JFVLHVOIP5ZC","created_at":"2026-05-18T12:26:09.077623+00:00"},{"alias_kind":"pith_short_16","alias_value":"JFVLHVOIP5ZC66KS","created_at":"2026-05-18T12:26:09.077623+00:00"},{"alias_kind":"pith_short_8","alias_value":"JFVLHVOI","created_at":"2026-05-18T12:26:09.077623+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P","json":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P.json","graph_json":"https://pith.science/api/pith-number/JFVLHVOIP5ZC66KSGG6CW6ZH4P/graph.json","events_json":"https://pith.science/api/pith-number/JFVLHVOIP5ZC66KSGG6CW6ZH4P/events.json","paper":"https://pith.science/paper/JFVLHVOI"},"agent_actions":{"view_html":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P","download_json":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P.json","view_paper":"https://pith.science/paper/JFVLHVOI","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1007.3447&json=true","fetch_graph":"https://pith.science/api/pith-number/JFVLHVOIP5ZC66KSGG6CW6ZH4P/graph.json","fetch_events":"https://pith.science/api/pith-number/JFVLHVOIP5ZC66KSGG6CW6ZH4P/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P/action/timestamp_anchor","attest_storage":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P/action/storage_attestation","attest_author":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P/action/author_attestation","sign_citation":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P/action/citation_signature","submit_replication":"https://pith.science/pith/JFVLHVOIP5ZC66KSGG6CW6ZH4P/action/replication_record"}},"created_at":"2026-05-18T04:35:48.845390+00:00","updated_at":"2026-05-18T04:35:48.845390+00:00"}