{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:JXWA3GZO36TJFTOGBIDPJVDKTK","short_pith_number":"pith:JXWA3GZO","schema_version":"1.0","canonical_sha256":"4dec0d9b2edfa692cdc60a06f4d46a9a8089da6faf4f34a39fcc37440cf2aa65","source":{"kind":"arxiv","id":"1506.06925","version":2},"attestation_state":"computed","paper":{"title":"Intrinsic limits to gene regulation by global crosstalk","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"C\\u{a}lin C. Guet, Ga\\v{s}per Tka\\v{c}ik, Nicholas H. Barton, Roshan Prizak, Tamar Friedlander","submitted_at":"2015-06-23T09:43:17Z","abstract_excerpt":"Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF-DNA interactions or remains erroneously inactive. We present a tractable biophysical model of global crosstalk, where many genes are simultaneously regulated by many TFs. We show that in the simplest regulatory scenario, a lower bound on crosstalk severity can be analytically derived solely from the number of (co)regulated genes and a suitable parameter that d"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1506.06925","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-06-23T09:43:17Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"3769c4a493426c97eea2ad64d8b74fdedd379a6c933c23a2a9603c8c8f4e1f7e","abstract_canon_sha256":"7ee1e37e72d132bdf56e65fcf604f0942f5ac655ccb85768d73d30882760ce5a"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:01:00.566238Z","signature_b64":"Z/8q9rtmwefeho7kSIVs021knB3pKTbwFRS+c4FpvcwJrtUS6oJ6Tscn3VSb4aSpAoeLVHygNJR97KXJxGWqCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4dec0d9b2edfa692cdc60a06f4d46a9a8089da6faf4f34a39fcc37440cf2aa65","last_reissued_at":"2026-05-18T01:01:00.565469Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:01:00.565469Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Intrinsic limits to gene regulation by global crosstalk","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"C\\u{a}lin C. Guet, Ga\\v{s}per Tka\\v{c}ik, Nicholas H. Barton, Roshan Prizak, Tamar Friedlander","submitted_at":"2015-06-23T09:43:17Z","abstract_excerpt":"Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF-DNA interactions or remains erroneously inactive. We present a tractable biophysical model of global crosstalk, where many genes are simultaneously regulated by many TFs. We show that in the simplest regulatory scenario, a lower bound on crosstalk severity can be analytically derived solely from the number of (co)regulated genes and a suitable parameter that d"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1506.06925","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1506.06925","created_at":"2026-05-18T01:01:00.565613+00:00"},{"alias_kind":"arxiv_version","alias_value":"1506.06925v2","created_at":"2026-05-18T01:01:00.565613+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1506.06925","created_at":"2026-05-18T01:01:00.565613+00:00"},{"alias_kind":"pith_short_12","alias_value":"JXWA3GZO36TJ","created_at":"2026-05-18T12:29:27.538025+00:00"},{"alias_kind":"pith_short_16","alias_value":"JXWA3GZO36TJFTOG","created_at":"2026-05-18T12:29:27.538025+00:00"},{"alias_kind":"pith_short_8","alias_value":"JXWA3GZO","created_at":"2026-05-18T12:29:27.538025+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK","json":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK.json","graph_json":"https://pith.science/api/pith-number/JXWA3GZO36TJFTOGBIDPJVDKTK/graph.json","events_json":"https://pith.science/api/pith-number/JXWA3GZO36TJFTOGBIDPJVDKTK/events.json","paper":"https://pith.science/paper/JXWA3GZO"},"agent_actions":{"view_html":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK","download_json":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK.json","view_paper":"https://pith.science/paper/JXWA3GZO","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1506.06925&json=true","fetch_graph":"https://pith.science/api/pith-number/JXWA3GZO36TJFTOGBIDPJVDKTK/graph.json","fetch_events":"https://pith.science/api/pith-number/JXWA3GZO36TJFTOGBIDPJVDKTK/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK/action/timestamp_anchor","attest_storage":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK/action/storage_attestation","attest_author":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK/action/author_attestation","sign_citation":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK/action/citation_signature","submit_replication":"https://pith.science/pith/JXWA3GZO36TJFTOGBIDPJVDKTK/action/replication_record"}},"created_at":"2026-05-18T01:01:00.565613+00:00","updated_at":"2026-05-18T01:01:00.565613+00:00"}